Kisdyanti, Yuniar Melissa
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Postoperative Cognitive Dysfunction in Craniotomy: Mechanisms, Challenges, and Future Directions Suandika, Made; Yantoro , Awal Tunis; Suhendro , Anton; Wijayanti, Indri; Handayani, Rahmaya Nova; Yulianto, Dwi Agus; Kisdyanti, Yuniar Melissa
Java Nursing Journal Vol. 3 No. 2 (2025): March - June 2025
Publisher : Global Indonesia Health Care (GOICARE)

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Abstract

Postoperative cognitive dysfunction (POCD) is a clinical concern that can affect patients undergoing craniotomy, often impairing memory, attention, and executive function. Despite advances in neurosurgical and anesthetic techniques, POCD remains prevalent and under-recognized. This review aims to explore the underlying mechanisms and contributing factors of POCD in the context of craniotomy under general anesthesia. A narrative literature review method was employed to examine publications retrieved from major databases including PubMed, Scopus, and ScienceDirect between 2015 and 2025. Selected studies focused on adult patients and provided insights into both clinical manifestations and molecular pathways linked to POCD. The analysis revealed that factors such as advanced age, duration of anesthesia, and neuroinflammatory responses significantly influence the development of POCD. Mitochondrial dysfunction and oxidative stress were frequently cited as key contributors to neuronal damage following surgery. In terms of clinical management, the literature suggests that early cognitive assessment and tailored anesthetic strategies may reduce the risk of long-term impairment. Although definitive treatment remains elusive, this review highlights the importance of early identification and multidisciplinary approaches to mitigate POCD in post-craniotomy patients. Future research should prioritize standardized diagnostic criteria and explore neuroprotective interventions to improve cognitive outcomes following neurosurgical procedures.
Impact of fast-track surgery on postoperative complications and patient satisfaction among diabetic patients undergoing elective surgery: a quasi-experimental study Suandika, Made; Handayani, Rahmaya Nova; Kisdyanti, Yuniar Melissa; Mondawitu, Kevin Virirey; Ayodhya Santam Budjana, The
Riset Informasi Kesehatan Vol 15 No 1 (2026): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v15i1.1132

Abstract

Background: Fast-Track Surgery (FTS) aims to optimise surgical recovery through multimodal interventions that reduce physiological stress and improve patient outcomes. However, its effectiveness among diabetic surgical patients remains underexplored, particularly regarding postoperative complications and satisfaction. Method: This quasi-experimental study compared 30 diabetic patients managed under an FTS protocol with 30 patients receiving conventional perioperative care at a tertiary hospital. FTS interventions included carbohydrate loading, early mobilisation, opioid-sparing analgesia, and structured discharge criteria. Outcomes assessed were postoperative complications and patient satisfaction, analysed using Chi-square and Mann–Whitney U tests. Results: The FTS group demonstrated fewer postoperative complications (20.0%) than the conventional group (46.7%, p = 0.015). Wound infection, transient hyperglycaemia, and thromboembolism were the most frequent events. Patient satisfaction was significantly higher in the FTS group (mean score 4.5 ± 0.6) compared to the conventional group (3.8 ± 0.7, p = 0.023). Multivariate analysis indicated FTS independently reduced complication risk (OR = 0.31, 95% CI: 0.10–0.89, p = 0.031). Conclusion: FTS effectively reduces postoperative complications and enhances satisfaction among diabetic patients undergoing elective surgery. Although limited by its non-randomised design and small sample size, this study highlights the potential of structured perioperative care for high-risk metabolic populations.