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All Journal Jurnal Gizi dan Pangan
Mohd Asmawi, Ummi Mohlisi
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Health Professions

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Association of Genetic Polymorphisms in the Human FTO Gene and Obesity: Systematic Review and Meta-Analysis Md Nor, Norazmir; Mohd Ruhaiddin, Nur Qairunnazirah; Khalid, Muhamad Shukry Khalid; Fikri, Al Mukhlas; Mohd Asmawi, Ummi Mohlisi
Jurnal Gizi dan Pangan Vol. 20 No. Supp.1 (2025)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2025.20.Supp.1.127-139

Abstract

The aim of the study is to perform a systematic review and meta-analysis to determine whether the Fat Mass and Obesity-associated (FTO) polymorphisms influenced obesity and which Single Nucleotide Polymorphisms (SNPs) raised the risk of obesity. We used PUBMED, SCOPUS, and Web of Science to identify studies investigating the association between genetic polymorphisms in the FTO gene and obesity. We discovered 16 studies that included 4,381 obese people and 5,652 healthy control people. Five genetic polymorphisms showed significant association with increased obesity risk in the allelic model: rs9939609 (OR=1.38, 95% CI:1.27−1.50: I²=0%, p<0.001), rs8050136 (OR=1.23, 95% CI:1.03−1.46: I²=54%, p=0.02), rs3751812 (OR=1.31, 95% CI:1.18−1.45: I²=4%, p<0.001), rs1421085 (OR=1.29, 95% CI: 1.14−1.46: I²=4%, p<0.001) and rs1121980 (OR=1.45, 95% CI: 1.10−1.93: I²=66%, p=0.009). For the allelic model, no significant correlation was identified in the rs15588902 SNP FTO gene (OR=1.24, 95% CI:0.96−1.62: I²=62%, p=0.11). Therefore, this meta-analysis found six FTO SNPs linked to human FTO polymorphisms and the risk of obesity. Further research on the FTO gene and obesity should consider gene-gene and gene-environment interactions.
Awareness, Knowledge, and Practices towards Reading Snack Food Labels among Malaysian Adolescents Md Nor, Norazmir; Mohd Rusli, Siti Farhanah; Mohd Asmawi, Ummi Mohlisi
Jurnal Gizi dan Pangan Vol. 18 No. 1 (2023)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2023.18.1.61-70

Abstract

This study aimed to determine the awareness, knowledge, and practices regarding food labels and factors that influence their use; a cross-sectional study was conducted among 200 Malaysian adolescents aged 10 to 19. Participants completed an online Food Label Use Questionnaire (FLUQ) that included demographic, nutrition knowledge, label use, and factors affecting label use. SPSS version 28.0 was used for data analysis. The results showed that 93% of adolescents correctly identified the consequences of over-consuming calories. Still, only 84.5% performed well on the nutrition use task, struggling to interpret calorie and carbohydrate amounts in certain foods. The main reasons for not using food labels were time constraints (45.5%), unattractive or confusing labels (36%), absence of labels on certain foods (33%), lack of health concerns (32%), and insufficient knowledge (27%). However, 90.5% of adolescents were concerned about product expiration dates and often read this information. Taste and price were the main reasons for referring to food labels, while time constraints were the main barrier to their use. In conclusion, practicing reading food labels can guide adolescents in making informed decisions about their food choices and portion intake. Awareness campaigns can aid in promoting healthy habits and empowering adolescents to make the right choices for their health.
Co-Authors Fikri, Al Mukhlas Khalid, Muhamad Shukry Khalid Md Nor, Norazmir Mohd Ruhaiddin, Nur Qairunnazirah Mohd Rusli, Siti Farhanah