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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Biomedika
Nordin, Noraziah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology

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EFFECTS OF HERBAL TEAS ON POLYCYSTIC OVARY SYNDROME (PCOS): A LITERATURE REVIEW Zukri, Nurul Fatehah; Nordin, Noraziah; Azzeri, Amirah
Biomedika Vol 17, No 2 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.10812

Abstract

Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects women of reproductive age. It is characterized by hormonal imbalances, metabolic disturbances, and anthropometric abnormalities. In recent years, the use of herbal teas as supplemental treatments for PCOS symptoms has gained popularity among people with the condition. This literature review aims to determine the impacts of herbal tea consumption on anthropometric parameters, identifying its effects on metabolic indices, and describing its influences on hormonal profiles. A thorough search of electronic databases was conducted to identify studies investigating the effects of herbal teas such as spearmint, cinnamon, chamomile, red clover, and hibiscus. The review included both observational research and clinical trials. The findings suggest that spearmint demonstrates the strongest evidence particularly for hormonal modulation in women with polycystic ovary syndrome. However, the available evidence is still inconsistent, with variations in study design, tea dosage, duration, and outcome measures. In conclusion, even though some herbal teas show potential as adjuvant therapy for PCOS, additional standardized research is required to prove the effectiveness of herbal teas and establish clear clinical recommendations.
In silico analysis of myricetin and fisetin as potential B-cell lymphoma extra-large (Bcl-xL) inhibitors in cancer therapy: Myricetin and fisetin as potential Bcl-xL inhibitors Nordin, Noraziah; Abd Ghani, Mohd Faiz; Roslan, Nuruliza; Riandini Aisyah; Sri Wahyuni; Peni Indrayudha; Em Sutrisna
Journal of Tropical Life Science Vol. 15 No. 3
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.15.03.02

Abstract

B-cell lymphoma extra-large (Bcl-xL) is an anti-apoptotic protein that is crucial for cancer cell survival and resistance to chemotherapy. Flavonoids have shown potential as anticancer agents through various pathways, including apoptosis. However, molecular interactions of flavonoids with Bcl-xL remain unknown. This study aims to evaluate the binding affinity and stability of myricetin and fisetin as Bcl-xL inhibitors using in silico approaches, including molecular docking and molecular dynamics (MD) simulations. Molecular docking was performed by AutoDock Vina software to evaluate the binding affinity of myricetin and fisetin to the Bcl-xL protein. MD simulations were conducted using the AMBER 2022.1 package to analyze the stability and dynamic behavior of the flavonoids-Bcl-xL complexes over a 100 ns trajectory. Docking analysis revealed strong binding affinities for both flavonoids, with fisetin exhibiting a slightly higher affinity (-7.6 kcal/mol) compared to myricetin (-7.2 kcal/mol). MD simulations confirmed the stability of both complexes, with myricetin forming a more extensive hydrogen bonding due to its additional hydroxyl groups, contributing to lower RMSD fluctuations and higher structural stability. Binding free energy calculations further supported the favorable interaction of myricetin with Bcl-xL (-61.542 kJ/mol), suggesting its potential as a potent inhibitor. In silico analysis indicates that both myricetin and fisetin have promising inhibitory potential against Bcl-xL, with myricetin demonstrating better stability and binding efficiency. These findings provide a basis for further experimental validation and the potential development of flavonoid-based Bcl-xL inhibitors for targeted cancer therapy.
Co-Authors Abd Ghani, Mohd Faiz Azzeri, Amirah Em Sutrisna Peni Indrayudha Riandini Aisyah Roslan, Nuruliza Sri Wahyuni Zukri, Nurul Fatehah