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All Journal Journal of Artificial Intelligence and Digital Business Biomedika
Fithriyah, Sa’idatul
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Medicine & Pharmacology

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INVESTIGATION OF THE ANTIBACTERIAL EFFICACY OF DERSONO WATER APPLE LEAVES (SYZYGIUM MALACCENSE) AS A SUBSTITUTE THERAPY FOR STREPTOCOCCUS PYOGENES INFECTIONS Rosyidah, Devi Usdiana; Mahmudah, Nur; Fithriyah, Sa’idatul; Sintowati, Retno
Biomedika Vol 17, No 1 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.12007

Abstract

Streptococcus pyogenes caused different illnesses, including pharyngitis and dermatological infections. The Dersono water apple leavesSyzygium malaccense) are recognized for their bioactive ingredients, which may serve as antibacterial agents. This study purpose was to determine the antibacterial potential of ethanol extract and acetone fraction of Syzygium malaccense against Streptococcus pyogenes infection. This research was a laboratory xperiment, a post-test only with control group design. Assessing growth inhibition by measuring the diameter of halo around the well of blood agar plate. Statistical tests using the Sapiro-Wilk test, Lavene test, Kruskal Wallis est and Mann-Whitney test. The study's findings demonstrated that the ethanol extract 25% (11.80 mm) and 50% (16.51) concentrations and acetone fraction of Dersono water apple leaves, at 25% (11.25 mm) and 50% (12.08) concentrations, had strong inhibitory power. The concentrations of 6.25% (8.15 mm) and 12.50% (9.63 mm), the ethanol extract's inhibitory power was superior than the concentrations of 6.25% (4.42 mm) and 12.50% (3.38 mm) acetone fraction, had moderate range. Both the ethanol extract and the acetone fraction's phytochemical analyses identified alkaloids, tannins, and saponins. The conclusion was ethanol extract and acetate fraction of Dersono water apple leaves have antibacterial effects against Streptococcus pyogenes.
Rintis Medikamentosa dalam Praktik Klinis: Diagnosis, Terapi, dan Pencegahan – A Narrative Review Putri, Nafisa Nathania Rema; Istiwa, Fadea Zahrotul; Aqila, Rana; Pratama, Rafi Sandi Putra; Fithriyah, Sa’idatul
RIGGS: Journal of Artificial Intelligence and Digital Business Vol. 4 No. 4 (2026): November - January
Publisher : Prodi Bisnis Digital Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/riggs.v4i4.4265

Abstract

Rinitis Medikamentosa (RM) merupakan bentuk rinitis non-alergi yang muncul akibat penggunaan kronis dekongestan topikal dan ditandai oleh obstruksi nasal persisten, perubahan histopatologis pada mukosa, serta risiko ketergantungan yang dapat memperburuk gejala dari waktu ke waktu. Narrative review ini bertujuan meninjau secara komprehensif aspek diagnosis, terapi, serta upaya pencegahan RM berdasarkan literatur terkini. Penelusuran artikel dilakukan melalui PubMed dan Google Scholar pada rentang tahun 2015–2025 dan menghasilkan 62 artikel, dengan 10 di antaranya memenuhi kriteria inklusi dan dianalisis lebih lanjut. Hasil telaah menunjukkan bahwa diagnosis RM terutama ditegakkan melalui anamnesis mengenai riwayat penggunaan dekongestan berlebihan, disertai pemeriksaan fisik yang umumnya memperlihatkan kongesti nasal difus, edema mukosa, dan eritema yang dapat dikonfirmasi melalui rinoskopi. Faktor risiko yang berkontribusi mencakup kebiasaan merokok, inflamasi mukosa kronis, paparan iritan lingkungan, serta kondisi psikologis tertentu yang mendorong penggunaan obat secara berulang. Tata laksana utama RM adalah penghentian dekongestan secara bertahap atau total, yang kemudian ditunjang dengan pemberian kortikosteroid intranasal, irigasi saline, serta intervensi bedah pada kasus refrakter yang tidak merespons terapi konservatif. Selain itu, edukasi pasien mengenai penggunaan obat yang benar, potensi efek samping, serta strategi pencegahan kekambuhan menjadi komponen penting dalam upaya menekan angka kejadian RM. Kombinasi pendekatan farmakologis, non-farmakologis, edukatif, dan prosedural menjadi strategi paling rasional dan efektif dalam tata laksana komprehensif RM.
Co-Authors Aqila, Rana Devi Usdiana Rosyidah Istiwa, Fadea Zahrotul Nur Mahmudah Pratama, Rafi Sandi Putra Putri, Nafisa Nathania Rema Retno Sintowati -