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All Journal Journal of Telenursing (JOTING) Jurnal Pengabdian kepada Masyarakat Nusantara
Faramarisa, Fara Nayo
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Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Nursing Social Sciences

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Regulasi Artemisin melalui Jalur CYP11A1 dan LONP1 dalam Mengobati Polycystic Ovarii Syndrome (PCOS) - Related Insulin Resistance Margolang, Muhammad Dary; Hidayah, Nurul; Hudawi, Fairuz Alifia Aksalansia; Faramarisa, Fara Nayo; Nurhuda, Yusa Amin
Journal of Telenursing (JOTING) Vol. 7 No. 4 (2025): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/908h0k04

Abstract

This study aims to analyze the therapeutic potential of Artemisia annua L. derivatives, specifically artemisinin, in modulating disrupted endocrine and metabolic pathways in PCOS. This research method utilized a literature review, with data sources consisting of journal articles and books related to the research topic. The results indicate that the pharmacological properties of artemisinin can treat PCOS-related insulin resistance through its regulatory interaction with the CYP11A1 and LONP1 pathways. Artemisinin can also enhance CYP11A1 degradation by directly binding to the mitochondrial protease LONP1, reducing androgen synthesis and alleviating insulin resistance. By targeting steroidogenesis and mitochondrial function, artemisinin emerges as a promising multi-target alternative therapy for PCOS with fewer side effects. In conclusion, artemisinin shows good molecular and clinical potential for overcoming insulin resistance in PCOS patients.   Keywords: Artemisinin, CYP11A1, LONP1, PCOS, Insulin Resistance
Deteksi Dini Kesehatan Melalui Cek Kesehatan Gratis di Lingkungan Universitas Darussalam Gontor Najie, Ilyu ‘Ainun; Iskandar, Dede; Nurhuda, Yusa Amin; Faramarisa, Fara Nayo; Tsabita, Khadija Kayyisha; Al Husna, Sabrina Yusrin; Harris, Jaudat Iqbal
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 7 No. 1 (2026): Edisi Januari - Maret IN PROGRESS
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v7i1.8185

Abstract

Penyakit tidak menular (PTM) masih menjadi masalah kesehatan utama yang berdampak pada kualitas hidup dan produktivitas, termasuk di lingkungan perguruan tinggi. Tingginya aktivitas civitas akademika berpotensi menurunkan kesadaran terhadap kesehatan sehingga risiko PTM sering tidak terdeteksi sejak dini. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan kesadaran serta melakukan deteksi dini kondisi kesehatan civitas akademika Universitas Darussalam Gontor melalui pemeriksaan kesehatan gratis. Metode yang digunakan meliputi pemeriksaan IMT, tekanan darah, gula darah, kolesterol, dan asam urat, disertai kuesioner riwayat kesehatan dan konsultasi dokter. Kegiatan yang dilaksanakan pada 13 Oktober 2025 diikuti oleh 287 peserta. Hasil menunjukkan mayoritas peserta berada pada kategori normal, namun masih ditemukan beberapa dengan faktor risiko PTM. Kegiatan ini efektif sebagai upaya deteksi dini dan edukasi kesehatan serta berpotensi mendukung pencegahan PTM di lingkungan universitas.
Co-Authors Al Husna, Sabrina Yusrin Dede Iskandar, Dede harris, jaudat iqbal Hudawi, Fairuz Alifia Aksalansia Margolang, Muhammad Dary Najie, Ilyu ‘Ainun Nurhuda, Yusa Amin NURUL HIDAYAH Tsabita, Khadija Kayyisha