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All Journal Journal of Telenursing (JOTING) JUKEJ: Jurnal Kesehatan Jompa
Nurhuda, Yusa Amin
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Regulasi Artemisin melalui Jalur CYP11A1 dan LONP1 dalam Mengobati Polycystic Ovarii Syndrome (PCOS) - Related Insulin Resistance Margolang, Muhammad Dary; Hidayah, Nurul; Hudawi, Fairuz Alifia Aksalansia; Faramarisa, Fara Nayo; Nurhuda, Yusa Amin
Journal of Telenursing (JOTING) Vol. 7 No. 4 (2025): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/908h0k04

Abstract

This study aims to analyze the therapeutic potential of Artemisia annua L. derivatives, specifically artemisinin, in modulating disrupted endocrine and metabolic pathways in PCOS. This research method utilized a literature review, with data sources consisting of journal articles and books related to the research topic. The results indicate that the pharmacological properties of artemisinin can treat PCOS-related insulin resistance through its regulatory interaction with the CYP11A1 and LONP1 pathways. Artemisinin can also enhance CYP11A1 degradation by directly binding to the mitochondrial protease LONP1, reducing androgen synthesis and alleviating insulin resistance. By targeting steroidogenesis and mitochondrial function, artemisinin emerges as a promising multi-target alternative therapy for PCOS with fewer side effects. In conclusion, artemisinin shows good molecular and clinical potential for overcoming insulin resistance in PCOS patients.   Keywords: Artemisinin, CYP11A1, LONP1, PCOS, Insulin Resistance
Pengaruh Penyuluhan Kesehatan Terhadap Pemahaman Madamat Tentang Slogan “Isi Piringku” Sebagai Upaya Pencegahan Penyakit Tidak Menular: English Najie, Ilyu Ainun; Nurhuda, Yusa Amin; Faramarisa, Fara Fayo; Suriyeni, Deni; Insan, Wachidah Nuril
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 4 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss4.2015

Abstract

Indonesia is currently undergoing a transition in lifestyle, dietary patterns, and demographics, which has led to a continuous increase in non-communicable diseases (NCDs). The main risk factor for NCDs is an unbalanced diet. My plate is a slogan for balanced nutrition, which, when applied in daily life, can help promote healthy eating habits among families and communities. Health education has great potential as an effective medium of education, aiming to determine the effect of health counseling on Madamat’s understanding of the “My Plate” slogan as a preventive effort against non-communicable diseases in families. It is also expected to encourage Madamat to adopt healthier dietary behaviors within their families as an early preventive measure against NCDs. This study used a quantitative method with a pre-experimental design, consisting of one large group with a pre-test and post-test pattern. The group included Madamat, namely the wives of lecturers and academic staff at UNIDA, totaling 30 participants. The research results were analyzed using frequency distribution with univariate and bivariate analysis, producing a significance value (p=0.000), indicating that health counseling had an effect on improving Madamat’s understanding of the “My Plate” slogan as a preventive measure against non-communicable diseases. The conclusion of this study is that there was a positive effect and an improvement in understanding as a result of health counseling, which contributed to enhancing Madamat’s knowledge regarding the prevention of non-communicable diseases through the application of “My Plate.”
Co-Authors Faramarisa, Fara Fayo Faramarisa, Fara Nayo Hudawi, Fairuz Alifia Aksalansia Insan, Wachidah Nuril Margolang, Muhammad Dary Najie, Ilyu Ainun NURUL HIDAYAH Suriyeni, Deni