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All Journal Jurnal Biologi Tropis Jurnal Ilmu Kedokteran dan Kesehatan
Putri, Shaffani Mahasuary
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Molecular Biomarkers in Traumatic Brain Injury: Diagnostic, Prognostic, and Therapeutic Perspective Setiasari, Febi Jian; Putri, Shaffani Mahasuary; Puspasari, Baiq Sagitta; Ilham, Muhammad Fadani
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10237

Abstract

Traumatic Brain Injury (TBI) remains a major global health problem due to its high morbidity and mortality rates. TBI can lead to cognitive and emotional impairments, and even increase the risk of neurodegenerative diseases such as Alzheimer's and Parkinson's. This review was compiled by searching literature discussing the role of molecular biomarkers in TBI, both from diagnostic and prognostic perspectives, as well as their therapeutic potential. The article search was conducted via PubMed, ScienceDirect, and Google Scholar using relevant keywords. The findings showed that with the increasing number of TBI cases, the limitations of CT scans and the Glasgow Coma Scale (GCS) in assessing subtle brain damage have spurred interest in molecular biomarkers. Biomarkers such as GFAP, S100B, tau protein, UCH-L1, and NF-L have been shown to detect biological changes not visible on routine imaging. GFAP emerges as the most promising candidate due to its high sensitivity and specificity in assessing injury severity. Thus, molecular biomarkers have the potential to improve diagnostic accuracy, predict prognosis, and support more effective rehabilitation strategies. The conclusion is that TBI is a global health problem with serious long-term impacts. Molecular biomarkers offer a great opportunity to complement conventional diagnostic methods. Although challenges remain in validation, standardization, and clinical application, further research can pave the way for the use of biomarkers as diagnostic and prognostic tools, as well as a basis for more personalized therapy in TBI patients.
Hubungan Klasifikasi Klinis Cerebral Palsy Dan Stres Pengasuhan Orangtua Putri, Shaffani Mahasuary; Karuniawaty, Titi Pambudi; Sari, Linda Silvana
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 2 (2026): Volume 13 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i2.22378

Abstract

Cerebral palsy (CP) adalah gangguan neurologis yang mempengaruhi kemampuan motorik dan fungsi sehari-hari, sehingga berpotensi meningkatkan stres pengasuhan orangtua. Penelitian ini bertujuan untuk mengetahui hubungan antara klasifikasi klinis CP dan tingkat stres pengasuhan orangtua. Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross-sectional pada 31 orangtua anak CP usia 0–18 tahun di Poliklinik Tumbuh Kembang RSUD Provinsi NTB (September–Desember 2024). Data dikumpulkan melalui klasifikasi klinis CP (GMFCS, MACS, EDACS) dan Parenting Stress Index-Short Form (PSI-SF). Analisis data dilakukan menggunakan uji korelasi Spearman’s rho dengan tingkat kemaknaan p0,05. Hasil penelitian menunjukkan bahwa mayoritas orangtua mengalami tingkat stres pengasuhan yang rendah dan tidak terdapat hubungan signifikan antara klasifikasi GMFCS (p=0,166), MACS (p=0,590), maupun EDACS (p=0,312) dengan tingkat stres pengasuhan orangtua. Temuan ini mengindikasikan bahwa derajat keterbatasan fungsional anak dengan CP tidak berhubungan secara langsung dengan tingkat stres pengasuhan orangtua, yang kemungkinan dipengaruhi oleh keberadaan faktor protektif seperti penerimaan orangtua, dukungan keluarga, dan akses terhadap terapi.
Co-Authors Ilham, Muhammad Fadani Karuniawaty, Titi Pambudi Puspasari, Baiq Sagitta Sari, Linda Silvana Setiasari, Febi Jian