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Harfan, Anita Anida
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Phytochemical Screening and Evaluation of in Vitro Anti-Inflammatory Activity of Ethanolic Extract of Terminalia Mantaly H. perrier Leaves Using BSA Protein Denaturation Assay Harfan, Anita Anida; Mulyani, Reni; Mulyadi, Dikdik
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10287

Abstract

The biological reaction to tissue damage known as inflammation is typified by the production of mediators including cytokines and prostaglandins. Long-term usage of non-steroidal anti-inflammatory medicines (NSAIDs) can have negative effects, despite their widespread use. This study explores the potential of Terminalia mantaly H. perrier (ketapang kencana), a plant known to contain various bioactive compounds, as a natural anti-inflammatory agent. The aim of this study was to analyze the phytochemical content and evaluate the anti-inflammatory activity of ethanol extracts of T. mantaly leaves using the Bovine Serum Albumin (BSA) protein denaturation method. 70% and 96% ethanol were used in the maceration process for extraction. The 70% ethanol extract included flavonoids, tannins, saponins, triterpenoids, terpenoids, and alkaloids, according to phytochemical screening. With an IC₅₀ value of 27,86 ppm Terminalia mantaly etanol extract 70%, the anti-inflammatory test revealed that the 70% ethanol extract at 400 ppm reduced protein denaturation by 92,29%, which was comparable to the inhibition by sodium diclofenac (84,04% at 50 ppm).  These results suggest that polar compounds in the 70% ethanol extract significantly contribute to its anti-inflammatory effect. Therefore, T. mantaly leaf extract demonstrates promising potential as a natural phytopharmaceutical candidate for inflammation therapy.
Co-Authors Dikdik Mulyadi Reni Mulyani