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All Journal Jurnal Impresi Indonesia Jurnal Locus Penelitian dan Pengabdian
Nurhidayati, Elita
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Religion Aerospace Engineering Automotive Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Law, Crime, Criminology & Criminal Justice Mathematics Social Sciences

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Lucio Phenomenon Mimicking Necrotizing Myofasciitis: A Case Report Study Nurhidayati, Elita; Dyah Ayu Saraswati, Putu
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 10 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i10.4363

Abstract

Lucio phenomenon is a rare but severe lepra reaction occurring in untreated patients with diffuse lepromatous leprosy, characterized by widespread cutaneous necrosis due to endothelial invasion and vascular thrombosis caused by Mycobacterium leprae. Its clinical resemblance to necrotizing soft tissue infections often leads to diagnostic confusion and inappropriate surgical intervention. We report a case of a 47-year-old man presenting with bilateral necrotic ulcers of the lower limbs, initially diagnosed as necrotizing myofasciitis and scheduled for debridement. However, further dermatological evaluation revealed hallmark signs of multibacillary leprosy, including madarosis, multiple anesthetic plaques, and sensory loss, in the absence of peripheral nerve thickening. A diagnosis of Lucio phenomenon was established, and surgical intervention was withheld in favor of initiating multidrug therapy (MDT) and supportive care. This case underscores the critical importance of early dermatological consultation and high clinical suspicion for atypical leprosy reactions in endemic regions, particularly in patients with rapidly progressive ulcers mimicking necrotizing infections.
Coincidence of Condyloma Lata and Condyloma Acuminata in an HIV Infected Patient Nurhidayati, Elita; Saraswati, Putu Dyah Ayu
Jurnal Impresi Indonesia Vol. 5 No. 1 (2026): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v5i1.7309

Abstract

Condyloma lata and condyloma acuminata are two distinct clinical manifestations caused by Treponema pallidum and low-risk human papillomavirus (HPV), respectively. While both are commonly encountered separately in individuals with high-risk sexual behavior, their coexistence in a single patient, particularly one with HIV infection, is rarely reported. We present the case of a 25-year-old man who has sex with men (MSM) and is living with HIV, presenting with multiple perianal lesions. Physical examination revealed verrucous, cauliflower-like growths and flat, moist erythematous plaques, consistent with condyloma acuminata and condyloma lata, respectively. Serologic tests were reactive for T. pallidum (TPHA positive, VDRL titer 1:32), supporting the diagnosis of active secondary syphilis. The patient, on regular antiretroviral therapy with a CD4 count of 350 cells/mm³, was treated with a single intramuscular injection of 2.4 million units of benzathine benzylpenicillin and received topical treatment for HPV-related lesions. Follow-up at four weeks demonstrated significant clinical improvement, along with a reduction in VDRL titer to 1:16. This case highlights the importance of clinical vigilance for multiple co-infections in immunocompromised patients and the need for thorough evaluation of overlapping anogenital lesions.
Co-Authors Dyah Ayu Saraswati, Putu Saraswati, Putu Dyah Ayu