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All Journal Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Layanan Masyarakat (Journal of Public Service)
Lim, Anthony Camilo
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Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Zebrafish Sebagai Model Hewan Coba Untuk Riset Diabetes Lim, Anthony Camilo; Rochmanti, Maftuchah; Khotimah, Husnul
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.10394

Abstract

Diabetes mellitus (DM) is a major global health problem, affecting over 500 million people worldwide. Understanding its pathophysiology and complications requires suitable animal models. Zebrafish (Danio rerio) has emerged as a promising model for diabetes research. This review aims to synthesize current research on the use of zebrafish as an experimental model for DM and its microvascular complications, focusing on induction methods, research applications, and observed outcomes. A literature review was conducted to investigate those variables. Zebrafish hyperglycemia can be induced through glucose immersion, overfeeding, chemical agents, and genetic modification. These models have been successfully used to study drug testing, molecular profiling, and diabetic complications. Observed variables included glucose levels, enzyme activity, gene expression, histopathological changes, and behavioral responses. Results demonstrated strong parallels with human diabetic pathology, including vascular alterations, proteinuria, renal apoptosis, and neuropathic dysfunction. Zebrafish provides a strong, cost-effective, and relevant model for diabetes research. Despite limitations such as physiological differences and methodological variability, they offer valuable insights into metabolic dysregulation and complications, while serving as an efficient platform for drug discovery.
“ANAK HEBAT, AYO CEK MATA”: A PROGRAM OF VISUAL ACUITY SCREENING IN CHILDREN OF SIDOREJO VILLAGE Lim, Anthony Camilo; Yusuf, Ahmad Adani Thirafi; Syifa, Nafla Rafida; Nurkhalisha, Firnida Hanan; Putra, Enrico Rabbani; Wijayakusuma, Almira Felicia; Santoso, Aina Cahyaning; Qonita, Salsabila Shafa; Naila, Nabila Putri; Kuswandari, Inna
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 9 No. 4 (2025): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v9i4.2025.581-592

Abstract

Visual impairment in children is a health issue that affects cognitive, social, and educational development, yet early detection at the preschool level is still rarely implemented. The community service program “Anak Hebat: Ayo Cek Mata!” was conducted to address this need in Sidorejo Village, Gresik Regency, where no previous screening of visual acuity had been carried out among children in Playgroup (KB) and Kindergarten (TK) or equivalent levels. The aim of this activity was to detect visual acuity problems early in preschool children so that timely referral and management could be provided. The implementation method consisted of four stages: needs identification through interviews with village officials and schools, activity planning through coordination with stakeholders, visual screening using the Peek Acuity application with standardized measurement procedures, and evaluation of activity. Data were analyzed descriptively and inferentially, including Fisher’s exact test. A total of 56 children participated, but only 39 children (69.6%) were successfully assessed for visual acuity. There was a significant association between age and measurement success (p<0.001). Among children with successfully measured visual acuity, 37 (94.8%) had no visual impairment, 1 child (2.6%) had mild impairment, and 1 child (2.6%) had moderate impairment. No association was found between either age or sex and visual acuity classification (p=0.858 and p=0.231). The limitations of the activity included low cooperativeness among children aged 3–4 years and the absence of alternative methods for children who did not yet understand instructions. Nevertheless, this program provides long-term benefits for the community, including serving as a basis for school vision health policies, supporting village-level health program evaluation, and encouraging the establishment of routine screening initiatives. Early detection at the preschool age is expected to prevent worsening visual impairment and improve children’s quality of life in the future.
Co-Authors Chatarina Umbul Wahyuni Inna Kuswandari Maftuchah Maftuchah Naila, Nabila Putri Nurkhalisha, Firnida Hanan Putra, Enrico Rabbani Qonita, Salsabila Shafa Santoso, Aina Cahyaning Syifa, Nafla Rafida Wijayakusuma, Almira Felicia Yusuf, Ahmad Adani Thirafi