Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Lalu Husnul Hidayat
Unknown Affiliation
Chemistry Education Health Professions Medicine & Pharmacology Other

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Preliminary In Vitro Antiplatelet Potential of Ipomoea pes-caprae from North Lombok with Adenosine Diphosphate-Induced Platelet Aggregation Ilsa Hunaifi; Dewi Suryani; Lalu Husnul Hidayat; Muhammad Naufal Farras Ananta; Muhammad Iqbal Farobbi; Nisa Isneni Hanifa; Raisya Hasina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.229-246

Abstract

Background: Cardiovascular diseases, particularly ischemic stroke, remain a global health burden, necessitating potential candidate for further antiplatelet with fewer side effects. Objectives: This study aimed to evaluate the antiplatelet potential of ethanolic extracts from the leaves and stems of Ipomoea pes-caprae (Katang-katang) from North Lombok, Indonesia, through ADP-induced platelet aggregation. Phytochemical screening, total tannin quantification, and in vitro antiplatelet assays were conducted. Methods: The leaves and stems were macerated with 96% ethanol, followed by qualitative phytochemical tests, Folin-Ciocalteu-based tannin analysis, and platelet aggregation inhibition assays using human platelet-rich plasma. Results: The extracts contained alkaloids, flavonoids, and tannins, with higher tannin levels in leaves (4.02 ± 0.02 mgEAT/g) than stems (3.67 ± 0.17 mgEAT/g). Concentration-dependent antiplatelet activity was observed, with leaf extracts showing inhibition (85.9% at 2000 μg/mL) compared to stems (79.5%) and aspirin (77.3%). IC₅₀ values were 727.78 μg/mL (leaves) and 349.95 μg/mL (stems). Statistical analysis confirmed significant differences across concentrations (p < 0.05). Conclusion: These findings demonstrate that Ipomoea pes-caprae exhibits potent antiplatelet activity, attributed to its tannin and phytochemical content, with leaves being more effective. Although these findings suggest preliminary antiplatelet potential, further analysis is required to validate the method using aspirin IC₅₀, and subsequent in vivo and pharmacological investigations are necessary before therapeutic application can be claimed.
POTENSI AKTIVITAS ANTIOKSIDAN DAN PENETAPAN KADAR FENOLIK TOTAL EKSTRAK DAUN KRATOM (Mitragyna speciosa Korth.) MENGGUNAKAN VARIASI PELARUT Riski, Akhmad; Nanang Fakhrudin; Agung Endro Nugroho; Rakhmadhan Niah; Lalu Husnul Hidayat
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2802

Abstract

Kratom (Mitragyna speciosa) is a medicinal plant native to Southeast Asia that contains a wide range of secondary metabolites. The characteristics of medicinal plant extracts are strongly influenced by the type of solvent used during the extraction process, particularly with respect to phenolic compounds that play a key role in antioxidant activity. This study aimed to evaluate the antioxidant activity and total phenolic content of Mitragyna speciosa leaf extracts obtained using solvents with different degrees of polarity. Kratom leaves were extracted with water using the decoction method, as well as with 70% and 90% ethanol using the maceration method. Total phenolic content was determined by Spectrophotometer UV–Vis employing the Folin–Ciocalteu reagent with gallic acid as the standard, while antioxidant activity was assessed based on IC₅₀ values using the DPPH assay. The results showed that the total phenolic content of the water, 70% ethanol, and 90% ethanol extracts was 81.27 ± 0.13, 93.85 ± 0.07, and 99.21 ± 0.07 mg GAE/g extract, respectively. Antioxidant activity analysis revealed IC₅₀ values of 64.71 µg/mL for the water extract (strong antioxidant), 35.52 µg/mL for the 70% ethanol extract (very strong antioxidant), and 35.12 µg/mL for the 90% ethanol extract (very strong antioxidant). Based on these findings, the 90% ethanol extract exhibited the highest total phenolic content and the most potent antioxidant activity, indicating its potential for development as a natural antioxidant source derived from kratom leaves.
Co-Authors Agung Endro Nugroho Dewi Suryani Ilsa Hunaifi Muhammad Iqbal Farobbi Muhammad Naufal Farras Ananta Nanang Fakhrudin Nisa Isneni Hanifa Raisya Hasina Rakhmadhan Niah Riski, Akhmad