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Helen Widiani
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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A Patient with Non-Hodgkin's Lymphoma of the Spinal Region with Tuberculosis Spondylitis Infection: A Case Report Helen Widiani; Losen Adnyana
MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/jzvag666

Abstract

Primary non-Hodgkin’s lymphoma (NHL) of spinal origin is very rare, accounting for only 0.1% of all NHL, with spinal cord compression is the first symptom. Tuberculosis (TB) spondylitis is a chronic granulomatous inflammatory disease of thespine caused by Mycobacterium tuberculosis. Some patients will experience neurological deficits. If the M. tuberculosis bacterial infection affects the vertebral body, the resulting damage causes spinal instability and disruption of the surrounding structures. Patients can experience paraparesis or tetraparesis due to compression of the spinal cord. This disease has symptoms such as back pain, kyphosis, and constitutional syndrome. A case of a 75-year-old male patient with non-Hodgkin’s lymphoma diffuse large cell region spine stage IV ECOG 4, tuberculosis spondylitis on antituberculosis drugs special regimen intensive phase.
Relationship Between Serum Vitamin D Levels  and Anxiety Severity in Elderly Patients at the Internal Medicinie and Psychiatry Clinic of RSUP Prof. dr. I.G.N.G Ngoerah Denpasar Helen Widiani; Tuty Kuswardhani
MEDICINUS Vol. 39 No. 2: MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/agbfxp34

Abstract

Serum vitamin D plays an important role in both physical and mental health. Decreased serum vitamin D levels in the elderly are often associated with anxiety. This study aims to determine the relationship between serum vitamin D levelsand anxiety severity in elderly patients. A cross-sectional analytical study was conducted and subjects were recruited using consecutive sampling at RSUP Prof. dr. I.G.N.G. Ngoerah. Serum vitamin D levels were measured using the human vitamin D Chemiluminescent Microparticle Immunoassay (CMIA), and anxiety severity were assessed using the Geriatric Anxiety Inventory (GAI). The median age of the participants was 66.5 years (range: 60–83 years). The most common anxiety severity observed was mild (40%) and the most prevalent vitamin D status was insufficient (40%). Statisticalanalysis showed no significant correlation between serum vitamin D levels and anxiety severity (p=0.816). The Spearman correlation test yielded a p-value of 0.214 with a correlation coefficient of -0.125. However, path analysis revealed thatvitamin D indirectly affects anxiety severity through inflammatory bowel syndrome (IBS), with an effect size of -0.06 (p=0.035).
Co-Authors Losen Adnyana R. A.T. Kuswardhani