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All Journal ACTA VETERINARIA INDONESIANA Jurnal Veteriner dan Biomedis
Ramadhan, Maharani Kartika
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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Impact of Spirulina platensis Extract as an Immunostimulant on the Histopathological Intestinal of Tilapia Fish (Oreochromis niloticus) Infected with Aeromonas salmonicida Ramadhan, Maharani Kartika; Kurniasih; Untari, Tri; Fadholly, Amaq
Jurnal Veteriner dan Biomedis Vol. 3 No. 2 (2025): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.3.2.%p.

Abstract

Furunculosis in fish results in financial detriment to freshwater aquaculture in Indonesia. Furunculosis, an infectious disease produced by Aeromonas salmonicida, presents a considerable risk to the large-scale farming of both salmonid and non-salmonid species in freshwater environments. This study sought to evaluate the impact of Spirulina platensis extract on the histopatological intestinal health of tilapia infected with Aeromonas salmonicida. Thirty tilapia, each around 10 cm in length, were distributed into five groups. Negative control (P0-) without immersion in Spirulina platensis extract and free from Aeromonas salmonicida infection. Positive control (P0 +) not immersed in Spirulina platensis extract, infected with Aeromonas salmonicida. Tilapia subjected to doses of 400 mg/L (P1), 600 mg/L (P2), and 800 mg/L (P3) The extraction of Spirulina platensis occurred for three hours on the seventh day (first immersion) and the fourteenth day (second immersion), followed by an evaluation of Aeromonas salmonicida infection on the twenty-first day. A necropsy of the fish was performed on day 28. Histopathological analysis revealed that Spirulina platensis extract reduced intestinal villous erosion and inflammatory cell density in the intestines of tilapia. Immunohistochemical staining demonstrated a decrease in the presence of Aeromonas salmonicida within intestinal tissue at a dosage of 800 mg/L. This work indicates that more research is necessary to examine the histological features of the intestines of tilapia infected with Aeromonas salmonicida with those supplemented with Spirulina platensis through feed.
Uji Toksisitas Akut Ekstrak Daun Ketepeng Cina (Cassia alata) pada Tikus (Rattus norvegicus) Ramadhan, Maharani Kartika; Fadholly, Amaq
Acta VETERINARIA Indonesiana Vol. 13 No. 2 (2025): Juli 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.2.%p

Abstract

The leaves of Cassia alata exhibit potential properties as antioxidants, immunostimulants, antimicrobials, anti-dengue agents, and laxatives. This study aimed to determine the LD50 value of the administration of Cassia alata leaves extract using the Thompson-Weil method. A total of 25 rats (Rattus norvegicus) were utilized in the study, divided into five dose groups. One group served as the control (P0), receiving only distilled water, while the four treatment groups were administered doses of 500 (P1), 1000 (P2), 1500 (P3), and 2000 (P4) mg/kg BW. Toxic symptoms and changes in body weight were observed for 14 days. The results showed that there was one death at a dose of 1500 mg/kg BW and two deaths at a dose of 2000 mg/kg BW. The administration of Cassia alata leaf extract resulted in toxic symptoms, including reduced motor activity, respiratory difficulties, and weight loss. The LD50 value obtained was 1.9 g/kg BW. The extract of Cassia alata leaves exhibit a toxic effect on rats.
Co-Authors Amaq Fadholly Kurniasih Tri Untari