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All Journal Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi)
Kumala, Ega Lucida Chandra
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Dentistry

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The impact of varying concentrations of hyaluronic acid gel on the enhancement of VEGF and angiogenesis expression Fauzia, Malianawati; Kumala, Ega Lucida Chandra; Aufani, Maulida; Syalisha, Addini Zoya; Wahyu, Adellia; Mukhlis, Muhammad Maulana Zikrullah
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.104632

Abstract

Periodontal dressings can contribute to plaque accumulation, which in turn may cause inflammation, irritation of healing tissues, bacteremia, and difficulties in eating. Advances in knowledge and technology have improved the materials used in these dressings, aiming to enhance effectiveness and minimize complications. High-molecular-weight hyaluronic acid (HMW-HA) is a promising dressing material because of its anti-inflammatory properties and its ability to promote epithelial regeneration. This study aimed to determine whether different concentrations of HMW-HA gel influence vascular endothelial growth factor (VEGF) expression and angiogenesis during gingival wound healing in white rats (Rattus norvegicus) of the Wistar strain. A total of 42 rats were divided into seven groups: a negative control group (K1), a positive control group (K2) treated with 0.2% Gengigel®, and five treatment groups (P1–P5) receiving HMW-HA gel at concentrations of 0.2%, 0.4%, 0.6%, 0.8%, and 1%, respectively. Standardized 2 mm wounds were created with a punch biopsy on the lower anterior jaw of each rat. Treatments were administered twice daily for seven days. VEGF expression and angiogenesis were evaluated using immunohistochemical and hematoxylin–eosin staining. The group treated with 1% HA gel (P5) showed the highest average VEGF expression and angiogenesis compared with the negative control and lower-concentration treatment groups. These findings suggest that topical application of HMW-HA gel may enhance gingival wound healing in periodontal surgery by promoting angiogenesis and increasing VEGF expression.
The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique Kumala, Ega Lucida Chandra; Fauzia, Malianawati; Junivianti, Hana Salsabila
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p184-188

Abstract

Background: The use of a bone graft in bone regeneration is challenging. Tooth graft material has been used as a bone graft alternative due to its similar composition of organic and inorganic materials close to the bone. Recently, nanotechnology has been used to improve bone graft quality. The osteoconduction rate in the defect area represents the bone graft quality. Purpose: This study aimed to compare the number of osteoblasts using nano-tooth grafts and micro-tooth grafts in Wistar rats. Methods: Wistar rats were divided into six groups: the negative control groups (examined on days 7 and 14), the micro-tooth graft groups (examined on days 7 and 14), and the nano-tooth graft groups (examined on days 7 and 14). The control group received nothing, the micro-tooth group received a micro-size tooth graft, and the nano-tooth graft group received a nano-size tooth graft on the injured femur. Histological observations of osteoblasts were carried out using a light microscope with 1000x magnification. Data were analyzed using one-way analysis of variance and least significant difference tests. Results: On day 7, the nano-tooth graft group showed a higher osteoblast number (11.75) than the micro-tooth graft group (7.5) (p = 0.039). There was no significant difference in the micro-tooth graft group compared to the control (p > 0.05). On day 14, the nano-tooth graft group showed a decrease in osteoblast number close to normal (control) (p > 0.05), while the micro-tooth graft group still experienced significant elevation. Conclusion: Nano-tooth grafts accelerate the stimulation of osteoblasts in the first stages of the healing process compared to micro-tooth grafts.
Co-Authors Aufani, Maulida Fauzia, Malianawati Junivianti, Hana Salsabila Mukhlis, Muhammad Maulana Zikrullah Syalisha, Addini Zoya Wahyu, Adellia