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All Journal Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi)
Kumala, Ega Lucida Chandra
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Dentistry

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Journal : Dental Journal (Majalah Kedokteran Gigi)

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Effect of tooth graft particle size on the healing process of femur defects in Wistar rat (Rattus norvegicus) Fauzia, Malianawati; Kumala, Ega Lucida Chandra; Brilliando, Okky Satria; Ayu, Devi Amelia; Napitu, Theresia Agata Winnitya
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p388-394

Abstract

Background: Teeth have potential as bone graft materials because of their organic and inorganic components that can stimulate osteoinduction, osteoconduction, and osteogenesis. An important success indicator of treatment using this graft material is the formation of osteoblast and new blood vessels in the applied area. Purpose: To investigate the number of osteoblast, osteoclast, and new blood vessels in bone healing after the implantation of tooth-derived bone graft materials measuring 20, 40, and 60 mesh. Methods: Thirty-six Wistar rats with a 2 mm defect on the right femoral dextra condile were divided into four groups. P0 (n=9) was the control group, where the defect was not filled by any material. In the other groups, the defects were filled by 20-mesh (P1; n=9), 40-mesh (P2; n=9), and 60-mesh (P3; n=9) tooth graft material. The Wistar rats were sacrificed after 2 weeks, and then the preparations were hematoxylin eosin staining. The data were analyzed using one-way analysis of variance and Tukey’s post hoc test. Results: The highest number of osteoblast was in the P3 group with a mean of 49.67, highest number of new blood vessels in the P2 group with a mean of 39.89, and highest number of osteoclast in the P1 group with a mean of 20.44. Statistical analysis showed a significant difference in the number of new blood vessels, osteoclast, and osteoblast in each group (p=0.000; p<0.05). Conclusion: Particle size differences in tooth graft material affect osteogenesis and angiogenesis in the bone healing process.
The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique Kumala, Ega Lucida Chandra; Fauzia, Malianawati; Junivianti, Hana Salsabila
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p184-188

Abstract

Background: The use of a bone graft in bone regeneration is challenging. Tooth graft material has been used as a bone graft alternative due to its similar composition of organic and inorganic materials close to the bone. Recently, nanotechnology has been used to improve bone graft quality. The osteoconduction rate in the defect area represents the bone graft quality. Purpose: This study aimed to compare the number of osteoblasts using nano-tooth grafts and micro-tooth grafts in Wistar rats. Methods: Wistar rats were divided into six groups: the negative control groups (examined on days 7 and 14), the micro-tooth graft groups (examined on days 7 and 14), and the nano-tooth graft groups (examined on days 7 and 14). The control group received nothing, the micro-tooth group received a micro-size tooth graft, and the nano-tooth graft group received a nano-size tooth graft on the injured femur. Histological observations of osteoblasts were carried out using a light microscope with 1000x magnification. Data were analyzed using one-way analysis of variance and least significant difference tests. Results: On day 7, the nano-tooth graft group showed a higher osteoblast number (11.75) than the micro-tooth graft group (7.5) (p = 0.039). There was no significant difference in the micro-tooth graft group compared to the control (p > 0.05). On day 14, the nano-tooth graft group showed a decrease in osteoblast number close to normal (control) (p > 0.05), while the micro-tooth graft group still experienced significant elevation. Conclusion: Nano-tooth grafts accelerate the stimulation of osteoblasts in the first stages of the healing process compared to micro-tooth grafts.
Co-Authors Aufani, Maulida Ayu, Devi Amelia Brilliando, Okky Satria Fauzia, Malianawati Junivianti, Hana Salsabila Mukhlis, Muhammad Maulana Zikrullah Napitu, Theresia Agata Winnitya Syalisha, Addini Zoya Wahyu, Adellia