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All Journal Jurnal Plastik Rekonstruksi Jurnal Locus Penelitian dan Pengabdian
Sandakh, Shaza Nathasya
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Aerospace Engineering Automotive Engineering Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Mathematics Other

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Mythbusting The Effect of BCAA on Wound Healing Tanaka, Ferdian; Sandakh, Shaza Nathasya; Hananto, Geovan; Setiadi, Antonius
Jurnal Plastik Rekonstruksi Vol. 12 No. 2 (2025): Jurnal Plastik Rekonstruksi
Publisher : The Lingkar Studi Bedah Plastik Foundation and is affiliated with the Department of Plastic Surgery, Faculty of Medicine, Universitas Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v12i2.24

Abstract

Nutrition plays a crucial role in the wound-healing process. Nutrition deficiencies can hinder the wound healing process and prolong the recovery period turning the wound into a chronic wound. One nutrient that is rarely discussed is BCAA (Branched Chain Amino Acid). BCAA are essential amino acids that are believed to accelerate the wound healing process. This study aims to investigate the effects of BCAA on the wound healing process. Studies have shown that BCAAs can increase serum albumin levels by preventing the formation of mRNA-PTB (Polypyrimidine Tract-Binding Protein) in liver cells, which activates and accelerates the wound healing process. Administering BCAA as a single treatment is not optimal; therefore, combined therapy with other essential amino acids is necessary. BCAAs can be administered orally, enterally, parenterally, and topically.
How Substantial is the Effect of Polyhexamethylene Biguanide (PHMB) Irrigation Solution on a Wound's Biofilm? Tanaka, Ferdian; Sandakh, Shaza Nathasya; Hananto, Geovan; Pamuji, Maurin A.; Arviansyah, Arviansyah
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 12 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i12.4982

Abstract

Background: Biofilm as a key component that contributes to the development of chronic wounds can increase the resistance of bacteria to antiseptic solutions. The current standard procedure for wound care involves the use of wound cleansing solutions such as povidone-iodine, chlorhexidine, and normal saline. Each of these solutions has limitations. One of the newer wound cleansing solutions is Polyhexamethylene Biguanide (PHMB). PHMB is known to inhibit the formation and disrupt the structure of biofilm. This study aims to conduct a systematic review and meta-analysis to evaluate the effectiveness of using PHMB as a wound irrigation solution in reducing biofilm in wounds. Methods: PubMed, Mendeley, ScienceDirect, and Cochrane were used as a database using the keywords for the analysis . Further exclusion using PICO criteria left us with  5 studies that met the inclusion criteria. Results: Our findings demonstrated a significant improvement in irrigation with PHMB group compared to the control group (MD= -5.09, 95% CI -8.40 to -1.78, p= 00001, I2= 99%,), there was significant biofilm reduction with the PHMB group compared to the control group (RD= 0.74, 95% CI 0.56 to 0.91, p= 00001, I2= 0%). Conclusion: Compared to standard wound irrigation solutions, PHMB presents several advantages. It acts as a potent bactericidal agent against biofilm-forming microbes, including both Gram-positive (Staphylococcus aureus and MRSA) and Gram-negative bacteria (Pseudomonas aeruginosa). Additionally, PHMB is effective against fungi (Candida albicans), does not induce pain, and is non-toxic to healthy cells and granulation tissue.
Co-Authors Arviansyah, Arviansyah Hananto, Geovan Pamuji, Maurin A. Setiadi, Antonius Tanaka, Ferdian