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All Journal PREPOTIF : Jurnal Kesehatan Masyarakat Cermin Dunia Kedokteran
Emeralda, Pradissa Avia
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Health Professions Public Health

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Eritroderma Diduga Akibat Reaksi Obat Allopurinol: Laporan Kasus: Laporan Kasus Emeralda, Pradissa Avia; Savitri, Dwiana
Cermin Dunia Kedokteran Vol 52 No 9 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i9.1513

Abstract

Introduction: Erythroderma is a condition of generalized erythema and scaling of the skin. It has been associated with DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome and is potentially life-threatening. Case: A 55-year-old female with generalized erythema, pruritus, malaise, and edema of her face for 7 days. She had a history of type 2 diabetes mellitus and was in oral allopurinol treatment for the last 2 weeks. Extensive generalized erythematous plaques and hyperkeratotic scales were observed on the face, neck, chest, arms, legs, back, and glutea. Laboratory workup revealed eosinophilia, mild hypoalbuminemia, hyperglycemia, and elevated liver enzyme level. Discussion: Erythroderma is an emergency case in dermatovenereology and needs hospitalization. A patient with drug-induced erythroderma with internal organ involvement has been associated with DRESS syndrome and needs further observation of cardiac, liver, and kidney status. Conclusion: Allopurinol is a potential trigger for erythroderma. Drug-induced erythroderma is closely related to DRESS syndrome. Allopurinol use requires caution to avoid complications and prevent recurrence.
HIGH CORTICOSTEROID TREATMENT FOR PSORIASIS VULGARIS CAUSING FATAL MANIFESTATION : A CASE REPORT Savitri, Dwiana; Emeralda, Pradissa Avia
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i1.27240

Abstract

Psoriasis adalah suatu penyakit inflamasi kulit bersifat kronis residif, dapat mengenai semua umur yang ditandai dengan plak kemerahan yang ditutupi oleh sisik yang tebal berwarna putih berlapis keperakan dan berbatas tegas. Seorang laki-laki berusia 29 tahun datang dengan keluhan bercak merah pada lengan, badan , kepala, tungkai sejak kurang lebih 2 tahun yang lalu. Pada pemeriksaan fisik didapatkan adanya plakat eritema, bulat konfluens, multiple dengan skuama kasar, berbatas tegas. Pasien tidak berobat kedokter tetapi oleh istrinya yang seorang perawat di injeksi dengan triamsinolon asetonide setiap hari selama hampir 2 tahun ini dan meminum dexamethasone tablet sekali sehari, karena kulit makin tampak memerah dan menipis maka pasien pergi berobat ke rumah sakit. Pemeriksaan manipulasi mendapatkan karsvlek phenomenon, Autzpits sign and Koebner phenomenon serta dilakukan biopsi kulit dengan kesimpulan psoriasis vulgaris. Setelah pasien menghentikan pemakaian steroid, pasien mendapatkan terapi yaitu cetirizin tablet 10 mg satu kali sehari, metotrexat 3 x 2,5 mg /minggu, asam folat tablet 1 x 1 mg sehari serta campuran salisilic acic 3%, liquor carbonis detergens (LCD) 5% dan klobetasol 0,05% krem serta krim asam fusidat. Pasien diberi edukasi mengenai cara perawatan kulit. Setelah 5 bulan pengobatan, lesi kulit mulai membaik dan kemerahan pada kulit berkurang.
ERITRODERMA AKIBAT REAKSI OBAT ALLOPURINOL Emeralda, Pradissa Avia; Savitri, Dwiana
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.32230

Abstract

Erythroderma is a condition of generalized erythema and scaling of the skin. More than 90% of the body surface area are involved in this condition accompanied by a various degree of scaling. This is potentially life-threatening and has been associated with DRESS syndrome. 1,3 The aim of this case report is to discuss the allopurinol drug reaction as aetiology of erythroderma, its clinical manifestations and management of therapy. We report a case of a 55-year-old female patient who had a generalized erythema, pruritus, malaise and edema of her face since 7 days before admitted. She had history diabetes mellitus type 2, and was in oral allopurinol treatment for last 2 weeks. Extensive generalized erythematous plaques and hyperkeratotic scales were observed in the face, neck, chest, arms, legs, back, and gluteal.  Laboratory workup revealed peripheral blood eosinophilia, mild hypoalbuminemia, hyperglycemia, and elevated liver enzyme level.  She was hospitalized and got treatment with dermatologist and internist.  Erythroderma is an emergency case in dermatovenereology and in severe case it needs therapy and hospitalization to avoid complication. Management of erythroderma include discontinuing of any potential causative drug, maintaining skin moisture and integrity, adequate hydration and nutrition, maintaining electrolyte balance, and antibiotics for secondary infection.  Patient with drug-induced erythroderma with internal organ involvement has been associated with DRESS syndrome and needs further observation in cardiac, liver, and kidney status. Allopurinol is potential drug which can trigger erythroderma. Erythroderma is a life-threatening disease especially in severe case. It is important to increase awareness in allopurinol medication and need a careful assessment and treatment to avoid complication.
Co-Authors Savitri, Dwiana