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All Journal Lantanida Journal Jurnal Buana Farma Nusantara Scientific Medical Research Journal
Silitonga, Desni Rinanda
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Veterinary

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EKSPLORASI AKTIVITAS HEPATOPROTEKTIF EKSTRAK ETANOL TEMU KUNCI (Boesenbergia rotunda) MELALUI PARAMETER MAKROPATOLOGI ORGAN HATI DAN INDEKS ORGAN PADA MODEL HEPATOTOKSISITAS TIKUS Harahap, Mawandha Sari; Jayanti, Heppy Nova; Silitonga, Desni Rinanda; Candrika
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1380

Abstract

Hati merupakan organ paling berperan dalam mayoritas sistem metabolisme pada tubuh. Metabolisme N-acetyl-p-aminophenol (APAP) memiliki metabolit reaktif N-acetyl-p-benzoquinone imine (NAPQI) yang dapat menyebabkan berkurangnya antioksidan glutation hati serta disfungsi mitokondria dan mengakibatkan meningkatnya jumlah radikal bebas dihati, yang pada akhirnya akan merusakkan hati. Antioksidan dibutuhkan guna meminimalisir radikal bebas. Rimpang temu kunci (Boesenbergia rotunda (L.) Mansf) mengandung metabolit sekunder berupa flavonoid yang diketahui memiliki sifat antioksidan sehingga rimpang temu kunci memiliki potensi untuk melindungi hati dari kerusakkan. Penelitian ini bertujuan untuk menganalisis aktivitas hepatoprotektif ekstrak etanol rimpang temu kunci terhadap tikus putih jantan yang diinduksi dengan APAP. Tikus putih jantan sebanyak 24 ekor digunakan pada penelitian ini, tikus dibagi dalam 6 kelompok perlakuan yakni kelompok kontrol normal, kontrol negatif diberi CMC-Na 0,5%, kelompok uji diberi ekstrak etanol rimpang temu kunci (EERTK) dosis 250, 500 serta 750 mg/kgBB dan kelompok kontrol positif diberi asetilsistein 200 mg. Selama 10 hari berturut-turut. Pada hari kesepuluh diinduksi dengan APAP 800 mg/kgBB secara oral. Setelah 16 jam, dilakukan pembedahan dan pengambilan organ hati. Organ hati untuk pengukuran indeks relatif organ dan makropatologi organ hati. Data dianalisis menggunakan one way-ANOVA lalu dilanjutkan Post Hoc Turkey HSD. Hasil analisis menjelaskan bahwa pretreatmen dengan EERTK secara signifikan menyebabkan indeks relatif organ hati menurun akibat dari pemberian EERTK, disisi lain EERTK juga memperbaiki makropatologi organ hati.
The Dangerous Of Using Food Preservatives To Human Health: A Review Tampubolon, Manuppak Irianto; Silitonga, Desni Rinanda; Ginting, Grace Anastasia br.; Berkat, Syukur; Sahputri, Cut Juliana; Ghifran, Muhammad Al; Marbun, Eva Diansari
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 02 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i02.127

Abstract

The use of formalin as a food additive remains a recurring issue in processed food products in Indonesia, particularly in perishable items such as wet noodles and tofu. This review examines ten published studies that investigated formalin detection across different regions of Indonesia using a range of analytical approaches, including the Nash reagent, UV-Vis spectrophotometry, rapid test kits, KMnO₄, Tollens reagent, and natural indicators. The findings reveal considerable regional variation in contamination levels, with positive results most frequently reported in Palembang, Yogyakarta, Tomohon, and Pringsewu, while samples from West Jakarta and Sorong were predominantly negative. Among the methods reviewed, the Nash reagent and UV-Vis spectrophotometry demonstrated higher accuracy and sensitivity, whereas simpler techniques were more appropriate for preliminary screening and public education. Overall, this review highlights the need for strong coordination between regulatory oversight, public awareness initiatives, and the availability of reliable detection methods to improve food safety in Indonesia.
DEVELOPMENT AND PHYSICOCHEMICAL EVALUATION OF ANTIOXIDANT PEEL-OFF MASKS CONTAINING ETHANOL EXTRACT OF CURRY LEAVES Silitonga, Desni Rinanda; Sirait, Tri Susanti; Fachrunniza, Yunda; Karo-Karo, Sry Ulina; Limbong, Yulia Safitri
Lantanida Journal Vol 14 No 1 (2026): January-June 2026
Publisher : UIN AR-RANIRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/8fb0n491

Abstract

Curry leaves (Bergera koenigii) are widely recognized for their rich phytochemical content and antioxidant properties; however, their application as active ingredients in cosmetic delivery systems remains relatively underexplored. This study aimed to evaluate the phytochemical profile and antioxidant activity of the ethanol extract of B. koenigii leaves and to investigate its potential incorporation into a peel-off mask formulation through physicochemical characterization. Antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, while formulation quality was evaluated through organoleptic properties, homogeneity, pH, viscosity, spreadability, drying time, stability testing for 28 days, cycling test, and skin irritation assessment. Phytochemical screening confirmed the presence of tannins, flavonoids, steroids, and saponins. The ethanol extract exhibited very strong antioxidant activity with an  value of 8.23 µg/mL, indicating a high free radical scavenging capacity. The formulated peel-off masks demonstrated stable physicochemical properties during storage, with viscosity values of 6,740–13,729 cPs, spreadability of 5.3–6.6 cm, drying time of 14.03–16.36 minutes, and pH values within the acceptable skin-compatible range (6.40–6.63). No irritation responses were observed in the preliminary skin test. These findings highlight the potential of B. koenigii ethanol extract as a promising natural antioxidant ingredient for peel-off mask cosmetic formulations.
Co-Authors Berkat, Syukur Fachrunniza, Yunda Ghifran, Muhammad Al Ginting, Grace Anastasia br. Harahap, Mawandha Sari Jayanti, Heppy Nova Karo-Karo, Sry Ulina Limbong, Yulia Safitri Marbun, Eva Diansari Sahputri, Cut Juliana Tampubolon, Manuppak Irianto Tri Susanti Sirait