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All Journal JURNAL FARMASIMED (JFM) JPS (Jurnal Pharma Saintika)
Rangki Astiani
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Health Professions Medicine & Pharmacology

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PERAN TABLET CURCUMA DALAM MENURUNKAN RISIKO HEPATOTOKSISITAS PADA PASIEN TB PARU YANG MENJALANI TERAPI OAT DI RS PASAR REBO KOTA JAKARTA TIMUR Dini Permata Sari; Nhila Putri Evani; Rangki Astiani
Journal Pharma Saintika Vol. 9 No. 1 (2025): Oktober : Jurnal Pharma Saintika
Publisher : Program Studi DIII Farmasi Akademi Farmasi Dwi Farma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51225/jps.v9i1.88

Abstract

Abstract: Curcuma is known to play a role in preventing the side effects of anti-tuberculosis drugs (OAT), including hepatotoxicity, by protecting liver cells from oxidative stress and inflammation induced by drugs. The objective of this study was to determine the relationship between Curcuma tablet supplementation and the level of liver damage (hepatotoxicity), as measured by AST, ALT, and total bilirubin levels in pulmonary tuberculosis patients at Pasar Rebo Hospital. This study was non-experimental and classified as an analytical study with a cross-sectional approach. Data collection was conducted retrospectively, by reviewing past medical data and events. The sample in this study consisted of a portion of pulmonary tuberculosis patients undergoing OAT therapy at Pasar Rebo Hospital, East Jakarta, during the period of January–December 2024. The results showed that Curcuma tablet supplementation provided significant benefits to the liver health of pulmonary TB patients, as indicated by a statistically significant decrease in AST, ALT, and total bilirubin levels (p < 0.05) after treatment. This decrease in liver enzyme and bilirubin levels reflects improved hepatic function and reduced hepatotoxicity. Thus, Curcuma tablets have been proven effective as a hepatoprotective agent in the context of OAT therapy..
Effectiveness of the Use of Analgetic Drugs in Sectio Caesarea (SC) Patients at RSAL Mintoharjo Atisi; Fajar Amirulah; Rizky Farmasita Budiastuti; Rangki Astiani; Atisi, Atisi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/0jfgbm77

Abstract

Cesarean section (CS) is a common obstetric surgical procedure that is frequently associated with moderate to severe postoperative pain, which may delay early mobilization and prolong recovery. This study aimed to evaluate the effectiveness of analgetic use based on the type and number of analgetics on pain intensity and recovery time in post-cesarean section patients at RSAL Mintoharjo. This research was conducted as an observational analytic study with a prospective cohort design involving 80 post-CS patients. Data were collected through medical records, direct observation, and pain assessment using the Numeric Rating Scale (NRS) at 6 hours, 24 hours and on day 2 or 3 postoperatively. Statistical analysis was performed using univariate analysis, Chi-Square test, and one-way ANOVA. The results show that the type of analgesic significantly affects pain intensity at all measurement times (p < 0,05), with combination analgetic regimens providing better pain control that single analgetics. The number of analgetics does not affect pain intensity at 6 hours postoperatively but shows a significant effect at 24 hours and during follow-up interviews. Recovery time is not significantly influenced by the type or number of analgesics, with most patients discharged within three days. Patient age and comorbidities affect pain intensity, while cesarean history and smoking status do not. In conclusion, multimodal analgesia is effective for controlling acute postoperative pain following cesarean section, whereas recovery time is more strongly influenced by patient clinical factors
Co-Authors Atisi Atisi, Atisi Dini Permata Sari Fajar Amirulah Farmasita Budiastuti, Rizky Nhila Putri Evani