Central obesity is a nutritional problem generally found in the world, both in developed and developing countries. Central obesity can lead to type-2 diabetes mellitus, cardiovascular disease, hypertension, sleep apnea, metabolic syndrome, and cancer. The results of the preliminary study demonstrated that seven out of 10 female students were in the category of central obesity. Female students with or without central obesity were known to rarely do physical activities and often consumed fast food. Objective: This study aimed to discover the relationship between fast food consumption and physical activity and the incidence of central obesity in the female students at the Undergraduate Program of Midwifery of Respati University Yogyakarta. Methods: This research is a quantitative study conducted using observational analytic techniques with a cross sectional approach. The instrument used was a questionnaire; the sampling technique used was the simple random sampling with a sample size of 107 female students. Data analysis was done using the Kendall tau test. Results: This study revealed that most of these female students had central obesity (51.4%). Forty percent of these female students always consumed fast food, and 54.2% of them did moderate physical activities. The results showed that there was a relationship between fast food consumption and central obesity (p=0.000, τ = 0.873). There was also a relationship between physical activity and the incidence of central obesity (p=0.000, τ = 0.401). Conclusion: There is a relationship between fast food consumption and physical activity and the incidence of central obesity