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All Journal Majalah Kedokteran Andalas Health and Medical Journal
Addina, Rina
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hubungan Ekspresi PD-L1 dengan Stadium Patologis dan Grading Karsinoma Urotelial Kandung Kemih Addina, Rina
Majalah Kedokteran Andalas Vol. 47 No. 4 (2024): MKA October 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i4.p457-464.2024

Abstract

Objective: To determine the relationship between Programmed Cell Death-Ligand 1 (PD-L1)   expression with histopathological variants, and staging of papillary thyroid carcinoma. Methods: This study is an observational research with a cross-sectional study. The sample consisted of papillary thyroid carcinoma cases from the Pathological Anatomy Laboratory of Dr. M. Djamil Padang General Hospital, spanning from January 2022 to December 2022, totaling 37 cases. Pathological stages of invasive urothelial carcinoma of bladder were assessed based on the TNM system WHO 2022 classification, and grades were evaluated according to the WHO 2022 classification. PD-L1 expression was assessed through immunohistochemical staining. Bivariate analysis was conducted using the Chi-square test, with statistical significance set at p < 0.05. Results: The study revealed a positive PD-L1 expression rate of 32.5%. Statistical analysis showed a significant association between PD-L1 expression and pathological stages of invasive urothelial carcinoma of bladder (p=0.019). High stages exhibited higher levels of PD-L1 expression. However, the study did not find a significant relationship between PD-L1 expression and grades of invasive urothelial carcinoma of bladder (p=0.152). Conclusion: There is an association between PD-L1 expression and pathological stages. PD-L1 expression is not associated with the grades of invasive urothelial carcinoma of bladder.
Peranan Imunohistokimia dalam Menentukan Origin dari Carcinoma of Unknown Primary Origin pada Kasus Massa Intra-abdomen Addina, Rina; Hilbertina, Noza
Health and Medical Journal Vol 5, No 3 (2023): HEME September 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i3.1343

Abstract

Pendahuluan : Carcinoma of Unknown Primary Origin (CUP) adalah kelompok kanker yang heterogen yang didefinisikan oleh adanya penyakit metastasis tanpa tumor primer yang teridentifikasi pada presentasi awal. Pemeriksaan Imunohistokimia (IHK) harus digunakan untuk mengidentifikasi asal jaringan. Laporan Kasus : Kami melaporkan sebuah kasus CUP pada laki-laki berusia 52 tahun dengan keluhan benjolan di perut sejak 2 bulan sebelum masuk rumah sakit. Pemeriksaan computerized tomography (CT) Scan memberikan kesan Gastrointestinal Stromal Tumor (GIST), tidak tampak massa pada traktus gastrointestinal, hepar,vesika felea, lien, ginjal, vesika urinaria dan prostat. Tindakan laparatomi dilakukan, pemeriksaan makroskopik didapatkan jaringan berukuran 24 cm x 22 cm x 6 cm, penampang putih kecoklatan. Pemeriksaan mikroskopik didapatkan kesan suatu GIST. Pemeriksaan IHK memperlihatkan ekspresi negatif untuk antibodi DOG1, CD117, CK7, CDX2, HepPar1 dan ekspresi positif untuk antibodi CK19 dan CD10. Kesimpulan : Penegakan diagnosis kasus ini berdasarkan hasil pemeriksaan fisik, radiologis, pemeriksaan histopatologi dan pemeriksaan lanjutan dengan IHK menyingkirkan GIST dan mengkonfirmasi origin hepatocellular carcinoma (HCC) berdasarkan ekspresi CK19 dan CD10. Hepatocellular carcinoma memiliki prognosis yang buruk jika positif terhadap pulasan CK19 (>5% sel tumor). Pemeriksaan IHK sangat dibutuhkan pada tumor dengan lokasi dan morfologi yang tidak jelas.
Co-Authors Noza Hilbertina, Noza