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All Journal Journal of Agromedicine and Medical Sciences Jurnal Penelitian Sains Jurnal Kesehatan Komunitas Majalah Patologi Indonesia Health and Medical Journal International Islamic Medical Journal Scientific Journal Cerdika: Jurnal Ilmiah Indonesia
Noza Hilbertina, Noza
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Treatment Problems In Triple Negative Breast Cancer Fasril , Thira; Hilbertina, Noza; Elliyanti, Aisyah
Jurnal Medis Islam Internasional Vol 4 No 2 (2023): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v4i2.3951

Abstract

Background: Breast cancer ranks second on the list of common diseases worldwide. It causes many deaths in the United States and Europe, second only to lung cancer. Triple-negative breast cancer (TNBC) does not express Estrogen Receptor (ER), Progesterone Receptor (PR), and Human Epithelial Receptor (HER2). It represents 24% of new cases of all breast cancer, and its incidence increases yearly. TNBC is a hormone-resistant breast cancer, so no current standard therapy exists. This article aims to explore regimen-resistant and troubleshooting treatment responses in TNBC cases. The method of writing this article is a literature review of studies using the keywords triple-negative breast cancer treatment and regimen, which are limited to only the most recent articles, 2012-2022, using search engines from PubMed, Science Direct, and Google Scholar. Results: There is no definitive therapy for the triple-negative breast cancer subtype, in which the TNBC type has no target receptor. Chemotherapy is the SOC of TNBC for early stage treatment. For late-stage and relapsed TNBC, however, chemotherapy is no longer the first choice. Currently there is no standard chemotherapy regimen that can be given to patients who experience relapse after chemotherapy because they will have a short response and lead to metastases. Some studies have shown that chemotherapy gives a better response, but the prognosis of TNBC remains poor. TNBC has different responses to therapy. TNBC showed a good response to combination chemotherapy along with pembrolizumab, capecitabine, olaparib, and radiotherapy, compared to chemotherapy by itself. Surgical therapy, such as Breast-Conserving Surgery (BCS), does not improve better prognosis in TNBC patients. Conclusions: Combining pembrolizumab, olaparib, capecitabine, and radiotherapy with chemotherapy increased survival rates compared to chemotherapy only.
Malondialdehyde Expression in HT29 Cells with Blastocystis sp. Exposure Rusjdi, Selfi Renita; Irawati, Nuzulia; Yanwirasti, Yanwirasti; Hilbertina, Noza
Journal of Agromedicine and Medical Sciences Vol. 10 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i3.47044

Abstract

Blastocystis sp. is one of the intestinal protozoa that is frequently found in stool specimens of colorectal cancer patients. This protozoan infection will trigger the host cell defense response to produce Reactive Oxygen Species (ROS) which causes oxidative stress. Oxidative stress can cause and aggravate colorectal cancer. Lipid peroxidation is one of the best indicators of ROS levels. Malondialdhyde is its end product so it is used as a marker of oxidative stress. This study aims to determine the exposure of Blastocystis sp. on malondialdehyde expression in colorectal cancer cell line HT29. This research is an experimental study in vitro. HT29 cells were treated with various concentrations of Blastocystis sp. antigen (0.005 μg/ml, 0.01 μg/ml, 0.05 μg/ml, 0.1 μg/ml and 0.5 μg/ml) for 72 hours. Malondialdehyde expression was examined using spectrophotometric method. Data analysis was performed using One Way Anova test. The results of the study are the mean expression of malondialdehyde in nmol/ml. The mean malondialdehyde levels of the control group, treatment with concentrations of 0.005 μg/ml, 0.01 μg/ml, 0.05 μg/ml, 0.1 μg/ml and 0.5 μg/ml were 3.134 nmol/ml, 2.682 nmol/ml, 2.556 nmol/ml, 2.744 nmol/ml, 2.84 nmol/ml and 3.286 nmol/ml respectively. The conclusion is that there is an effect of exposure to Blastocystis sp. on malondialdehyde expression of HT29 cells. Keywords: Blastocystis sp., HT29, malondialdehyde
Analisis Karakteristik Klinikopatologi Kanker Kolorektal di Laboratorium Patologi Anatomi RSUP Dr. M. Djamil 2020-2022 Aden, Kuntum Annisa Tiara; Mulyani, Henny; Suchitra, Avit; Hilbertina, Noza; Nurhayati, Nurhayati
Jurnal Penelitian Sains Vol 27, No 1 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i1.1181

Abstract

 Kanker kolorektal adalah kanker yang tumbuh di kolon (usus besar) dengan kejadian yang terus meningkat setiap tahun. Faktor yang menentukan prognosis kanker kolorektal adalah usia, jenis kelamin, jenis keganasan, topografi, dan histopatologi. Penelitian ini bertujuan untuk mengenali jenis – jenis kanker kolorketal dan bagaimana karakteristik klinikopatologinya di Laboratorium Patologi Anatomi RSUP Dr. M. Djamil Padang tahun 2020 - 2022. Penelitian dilakukan dengan metode deskriptif observasional dengan teknik total sampling dari rekam medis. Kriteria inklusi sampel adalah seluruh pasien kanker kolorektal yang menjalani reseksi tahun 2020 - 2022 dengan diagnosis pertama kali dengan jumlah sampel 196 sampel. Hasil penelitian menunjukkan bahwa kanker kolorektal paling banyak terjadi pada pasien pada usia lebih dari 50 tahun (63,3%), jenis kelamin perempuan (51%), dan lokasi kanker kolorektal yang paling banyak dijumpai di rektum (44,9%), dengan ukuran tumor berkisar dari 4 sampai 6 cm (34,7%). Jenis keganasan yang paling sering ditemukan adalah Adenocarcinoma NOS di rektum. Kesimpulan penelitian ini adalah bahwa dalam rentang tahun 2020 – 2022, insiden kanker kolorektal terbanyak di Laboratorium Patologi Anatomi RSUP Dr. M. Djamil Padang adalah perempuan usia di atas 50 tahun dengan jenis keganasan berupa Adenocarcinoma NOS di rektum.
Kasus Jarang Karsinoma Sekretori Kelenjar Liur: Penegakkan Diagnosis yang Tepat Tanpa Pemeriksaan Molekuler Wildanur, Sri Wildanur; Hilbertina, Noza; Setiawati, Yessy
Health and Medical Journal Vol 7, No 2 (2025): HEME May 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i2.1668

Abstract

Karsinoma sekretori kelenjar liur adalah karsinoma tingkat rendah yang ditandai dengan kemiripan morfologis dengan karsinoma sekretori mammae dan fusi gen ETV6-NTRK3. Kami melaporkan kasus jarang seorang perempuan berusia 53 tahun dengan benjolan pada parotis sejak 6 bulan. Pemeriksaan histopatologi dari spesimen parotidektomi memperlihatkan proliferasi sel tumor membentuk struktur mikrokistik dengan lumen berisi sekret eosinofilik, sitoplasma granular eosinofilik dan bervakuol. Diagnosis banding utama karsinoma sekretorik adalah dengan karsinoma sel asinik derajat rendah. Keduanya dapat dibedakan dengan pemeriksaan histokimia PAS positif pada sekret dan imunohistokimia positif kuat untuk S100 serta negatif untuk DOG1. Identifikasi translokasi t(12;15) (p13;q25) merupakan standar emas untuk diagnosis. Pada sumber daya rendah di mana analisis molekuler tidak tersedia, maka pemeriksaan histopatologi dan menggunakan imunohistokimia merupakan alat kunci untuk menegakkan diagnosis yang tepat.
A Rare Case of Multiple Hereditary Exostosis: Making The Correct Diagnosis with Triple Diagnosis Ramadhani, Rahmi; Hilbertina, Noza; Yenita; Tofrizal; Mayorita, Pamelia; Devianti, Loli; O ktora, Meta Zulyati
Scientific Journal Vol. 4 No. 4 (2025): SCIENA Volume IV No 4, July 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i4.248

Abstract

Background: A rare genetic disorder characterized by the development of multiple benign bone tumors called osteochondromas. This condition is primarily hereditary and follows an autosomal dominant pattern of inheritance, with mutations in the EXT1 and EXT2 genes being the most common genetic. Case report: This case report describes an 12-year-old boy with lumps in all four extremities accompanied by intermittent pain. Femur x-rays concluded MHE of the femur, tibia, and bilateral fibula. Histopathological examination shows that the cartilage tissue contains chondrocyte cells that form the cartilage cap. There is a transition of cartilage to bone trabeculae through endochondral ossification and bone marrow between the bone trabeculae. Discussion and Conclusion: MHE is a rare condition, with an incidence of approximately 1 in 50,000 to 100,000 live births. MHE is closely related to genetic mutations that occur in the EXT1, EXT2, and EXT3 genes. These genes code for enzymes involved in the biosynthesis of heparan sulfate, which is necessary for normal bone growth. Mutations in any of these genes disrupt the regulation of bone growth and lead to osteochondroma formation. Symptoms of MHE can range from mild to severe, and they tend to appear in childhood or adolescence. The main clinical manifestations include the formation of a hard lump on the bone, which can cause deformity, pain, and limitation of movement. Osteochondroma can also compress nerves or blood vessels, causing complications such as circulatory disorders or paralysis. We report a rare case emphasizing the typical morphology of multiple hereditary exostosis of the long bones to establish the final diagnosis without immunohistochemistry and molecular examination. In low-resource settings where molecular analysis is not available, histopathological examination are key tools to establish a correct diagnosis.
Fine Needle Aspiration Biopsy as A Useful Diagnostic Adjunct in The Management of Ameloblastoma: A Cytology Case Report Rasfa, Rum Affida; Intan, Shinta Ayu; Hilbertina, Noza; Oktora, Meta Zulyati
Scientific Journal Vol. 4 No. 4 (2025): SCIENA Volume IV No 4, July 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i4.249

Abstract

Background: Ameloblastoma is one of the most common benign odontogenic tumors, known for its slow growth but locally invasive behavior, often leading to extensive bone destruction if not diagnosed and treated early. Preoperative diagnosis of ameloblastoma can be made by Fine Needle Aspiration Biopsy (FNAB) which is used as a guide for surgical planning. Diagnosis of ameloblastoma from cytology is challenging due to many pitfalls and differential diagnosis with other odontogenic lesions, but proper sampling and accurate diagnosis are very useful inpatient management Understanding its cytomorphological features can greatly assist in early differentiation from other maxillofacial neoplasms. This case report aims to describe the appearance of ameloblastoma on FNAB and reveal the contribution of the FNAB examination in the preoperative diagnosis of ameloblastoma so that adequate surgery can be carried out and the results are more optimal. Case report: We report a case of a tumor in the mandible of a 16-year-old man with a diagnosis of right mandibular tumor. The patient was sent for FNAB to the anatomical pathology laboratory. Preoperative cytology examination showed benign odontogenic lesions indicating ameloblastoma from FNAB. Furthermore, tumor resection was performed on the patient and histopathology tissue examination was performed with results consistent with ameloblastoma. Discussion: The FNAB procedure can be performed to establish for a pre-operative diagnosis of ameloblastoma. Cytological characteristics of ameloblastoma include basaloid cells or epithelial cells resembling ameloblasts with nuclei arranged palisade at the periphery and in the middle consisting of cells resembling stellate reticulum cells. False-negative results in the FNAB procedure can occur due to inadequate specimens or inaccurate sampling, mostly related to cystic tumors. To avoid this, FNAB tissue sampling can be performed at multiple sites and the deeper aspects of the tumor can assist in establishing an accurate preoperative diagnosis. Conclusion: The FNAB cytology is a reliable procedure for the pre-operative diagnosis of ameloblastoma. Pre-operative diagnosis of ameloblastoma can be used for planning therapy and early diagnosis of recurrence cases that can improve patient survival. The correlation between t
Faktor Determinan Perilaku Deteksi Dini Kanker Payudara dengan SADARI pada WUS di Puskesmas Padang Pasir Ginting, Desi Scorpinasari; Asri, Aswiyanti; Karmia, Hudila Rifa; Hilbertina, Noza; Meinapuri, Malinda; Hasmiwati, Hasmiwati
Jurnal Kesehatan Komunitas Vol 11 No 2 (2025): Jurnal Kesehatan Komunitas
Publisher : LPPM Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/keskom.Vol11.Iss2.2267

Abstract

Breast cancer is the most commonly diagnosed cancer globally, accounting for nearly 12% of all cases. One in eight women worldwide is at risk of developing breast cancer. Regular Breast Self-Examination (BSE) is one of the most effective methods for early detection. This study aimed to identify the determinants of early breast cancer detection behavior through BSE among women of reproductive age. The study found significant associations between BSE behavior and several predisposing factors, including education level (p = 0.002), knowledge (p = 0.000), perception (p = 0.009), attitude (p = 0.024), and motivation (p = 0.016); enabling factor, namely information exposure (p = 0.000); and reinforcing factors, including family support (p = 0.001) and support from health workers (p = 0.027). Conversely, there was no significant association between social support and BSE behavior (p = 0.394). The study concludes that predisposing, enabling, and reinforcing factors are significantly associated with BSE behavior. Information exposure is identified as the most influential determinant of BSE behavior among women in the working area of Padang Pasir Public Health Center.
And, The, Of, In SOX10 and The Tendency of Perineural Invasion in Salivary Gland Adenoid Cystic Carcinoma: SOX10 and The Tendency of Perineural Invasion Safnita, Dewi; Hilbertina, Noza; Mulyani, Henny; Tofrizal; Khambri, Daan; Yetti, Husna
Majalah Patologi Indonesia Vol. 34 No. 3 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT Background Adenoid cystic carcinoma is a malignant salivary gland tumor with unique features, including slow growth, progressive, poor prognosis, recurrence propensity, and perineural invasion tendency. SOX10 is a transcription factor expressed in the majority of tumors. SOX10 overexpression was hypothesized to play an important role in tumor-stroma interactions, especially perineural invasion and histopathological patterns. Method A cross-sectional study was performed using 30 blocks of formalin-fixed embedded specimens previously diagnosed as salivary gland adenoid cystic carcinomas. Perineural invasion and histopathological patterns were evaluated followed by immunohistochemical staining to evaluate SOX10 expression. The staining intensity and proportion of positively stained cells in both tumor and stroma cells were grouped into high and low expression levels. Chi-square tests were used for statistical analysis. Result The cribriform pattern was the most common histopathological pattern in both high and low SOX10 expression. The majority of tumors with high SOX10 expression (66.67% in stroma cells and 73.33% in tumor cells) were found to have more perineural invasion. Conclusion There was a tendency for perineural invasion in tumors with high SOX10 expression, although this was not statistically significant. There was no significant association between SOX10 expression and histopathological pattern.
Association of α-SMA and EpCAM Expressions with Recurrence Risk Based on Histopathological Subtypes of Basal Cell Carcinoma Yona, Fajriza; Hilbertina, Noza; Mulyani, Henny; Bachtiar, Hafni
Majalah Patologi Indonesia Vol. 33 No. 1 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i1.613

Abstract

Background Basal cell carcinoma (BCC) is the most common skin malignancy in the world with a proportion 70%. Recurrent and aggressive variants are still challenging in diagnosis and treatment. Histopathologically, there are two group of BCC risk of recurrence, i.e low risk and high risk. Assessment the expression of alpha-smooth muscle actin (α-SMA) as a biomarker of cancer associated fibroblast cell in stroma and the expression of epithelial cell adhesion molecule (EpCAM) in tumor cells probably have role in the pathomechanism of BCC progression, suggest its can distinguish the risk of BCC recurrence. This research aims to determine the assosiation between the expression of α-SMA and EpCAM with the recurrence risk group of BCC histopathological subtypes. Methods This was a cross sectional study using 48 samples, with 24 low and high risk groups each. Histopathological subtypes were determined from Hematoxylin and eosin slide. The expression of α-SMA and EpCAM was examined by the immunohistochemical method which was assessed semiquantitatively. Statistical analysis was performed using the Chi-square test with p<0.05 was considered significant. Results Expression of α-SMA with the score 3 was found more in high risk BCC (85.7%), while a score of 1 was more in low risk BCC (100%). Loss of EpCAM expression was mainly found in high risk BCC (82.8%). Statistical analysis showed that there was a significant assosiation between the expression of α-SMA and EpCAM and the recurrence risk group of BCC histopathological subtypes with p value =0.000 for each. Conclusions This study concluded that increased of α-SMA expression and loss of EpCAM expression were associated with a high recurrence risk group of BCC histopathological subtypes.
Peranan Imunohistokimia dalam Menentukan Origin dari Carcinoma of Unknown Primary Origin pada Kasus Massa Intra-abdomen Addina, Rina; Hilbertina, Noza
Health and Medical Journal Vol 5, No 3 (2023): HEME September 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i3.1343

Abstract

Pendahuluan : Carcinoma of Unknown Primary Origin (CUP) adalah kelompok kanker yang heterogen yang didefinisikan oleh adanya penyakit metastasis tanpa tumor primer yang teridentifikasi pada presentasi awal. Pemeriksaan Imunohistokimia (IHK) harus digunakan untuk mengidentifikasi asal jaringan. Laporan Kasus : Kami melaporkan sebuah kasus CUP pada laki-laki berusia 52 tahun dengan keluhan benjolan di perut sejak 2 bulan sebelum masuk rumah sakit. Pemeriksaan computerized tomography (CT) Scan memberikan kesan Gastrointestinal Stromal Tumor (GIST), tidak tampak massa pada traktus gastrointestinal, hepar,vesika felea, lien, ginjal, vesika urinaria dan prostat. Tindakan laparatomi dilakukan, pemeriksaan makroskopik didapatkan jaringan berukuran 24 cm x 22 cm x 6 cm, penampang putih kecoklatan. Pemeriksaan mikroskopik didapatkan kesan suatu GIST. Pemeriksaan IHK memperlihatkan ekspresi negatif untuk antibodi DOG1, CD117, CK7, CDX2, HepPar1 dan ekspresi positif untuk antibodi CK19 dan CD10. Kesimpulan : Penegakan diagnosis kasus ini berdasarkan hasil pemeriksaan fisik, radiologis, pemeriksaan histopatologi dan pemeriksaan lanjutan dengan IHK menyingkirkan GIST dan mengkonfirmasi origin hepatocellular carcinoma (HCC) berdasarkan ekspresi CK19 dan CD10. Hepatocellular carcinoma memiliki prognosis yang buruk jika positif terhadap pulasan CK19 (>5% sel tumor). Pemeriksaan IHK sangat dibutuhkan pada tumor dengan lokasi dan morfologi yang tidak jelas.
Co-Authors Addina, Rina Adelia Rachmita, Prima Aden, Kuntum Annisa Tiara Aisyah Elliyanti Arnofyan, Budi Pratama Aswiyanti Asri Daan Khambri Devianti, Loli Fasril , Thira Ginting, Desi Scorpinasari Hafni Bachtiar Hasmiwati henny Mulyani Husna Yetti Intan, Shinta Ayu Karmia, Hudila Rifa Kusumardani, Dini Malinda Meinapuri Mayorita, Pamelia Nurhayati Nurhayati Nuzulia Irawati O ktora, Meta Zulyati Oktora, Meta Zulyati Pawitan, Jeanne Adiwinata Rahmi Ramadhani Rum Affida Rasfa Safnita, Dewi Salmiah Agus Selfi Renita Rusjdi Setiawati, Yessy Suchitra, Avit Tofrizal Wildanur, Sri Wildanur Yanwirasti Yanwirasti Yenita . Yona, Fajriza