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All Journal Jurnal Sains dan Teknologi Jurnal Sains dan Edukasi Sains Indonesian Journal of Applied Research (IJAR)
Yuliani, Ririn Kholifatu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Materials Science & Nanotechnology Mathematics Physics Other

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Efektivitas Nanogel Ekstrak Daun Getih-Getihan (Rivina humilis) Sebagai Obat Penyembuhan Luka Robek pada Tikus Aji, Oktira Roka; Tufahati, Nadhira; Yuliani, Ririn Kholifatu; Ilma, Nur Malika; Salimah, Azizah Zahratus
Jurnal Sains dan Edukasi Sains Vol. 8 No. 2 (2025): Jurnal Sains dan Edukasi Sains
Publisher : Faculty of Science and Mathematics, Universitas Kristen Satya Wacana, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24246/juses.v8i2p159-166

Abstract

Getih-getihan (Rivina humilis) merupakan tanaman liar yang sering ditemukan tumbuh di sekitar pekarangan rumah atau lahan kosong. Daun dari tanaman getih-getihan diketahui mengandung berbagai senyawa aktif, salah satunya adalah flavonoid yang memiliki sifat antiinflamasi sehingga sangat berpotensi dalam mempercepat proses penyembuhan luka. Penelitian ini bertujuan untuk mengetahui efektivitas berbagai konsentrasi nanogel ekstrak daun getih-getihan dalam membantu proses penyembuhan luka robek pada hewan uji tikus (Rattus norvegicus). Metode dalam penelitian ini  yang digunakan untuk menguji efektivitas konsentrasi nanogel ekstrak daun getih-getihan yaitu dengan menggunakan analisis eksperimental. Analisis data dilakukan dengan pengujian ANOVA untuk melihat perbedaan yang signifikan, dan kemudian dilanjutkan dengan uji lanjutan dengan analisis Duncan-Multiple Range Test (DMRT) untuk melihat kelompok perlakuan yang paling efektif. Hasil pengujian efektivitas nanogel ekstrak daun getih-getihan dengan konsentrasi 2 %, 4%, dan 6% b/v pada tikus (Rattus norvegicus) menunjukkan nanogel yang paling efektif dalam penyembuhan luka adalah pada konsentrasi 6%. Karena pada hari ke 6 menunjikan bahwa kondisi bekas luka sayatan sudah tertutup sempurna. Dengan demikian, dapat disimpulkan bahwa nanogel ekstrak daun getih-getihan dengan konsentrasi 6% merupakan formulasi paling efektif dalam mempercepat penyembuhan luka robek. Hasil penelitian ini menunjukkan potensi besar tanaman liar untuk dapat dikembangkan menjadi produk obat yang berbasis herbal sehingga aman dan ramah lingkungan.
Aktivitas Antibakteri Ekstrak Daun Rivina humilis L. Terhadap Staphylococcus aureus dan Pseudomonas aeruginosa Yuliani, Ririn Kholifatu; Ilma, Nur Malika; Tufahati, Nadhira; Salimah, Azizah Zahratus; Aji, Oktira Roka
JST (Jurnal Sains dan Teknologi) Vol. 14 No. 1 (2025): April
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jstundiksha.v14i1.93228

Abstract

Rivina humilis (getih-getihan) is a wild plant that contains bioactive compounds that have the can to be used as antibiotics. This study aims to determine the antibacterial activity of ethanol extract of getih-getihan leaves against Staphylococcus aureus (Gram positive) and Pseudomonas aeruginosa (Gram negative) bacteria through in vitro experimental research. The subject used in the study was getih-getihan (Rivina humilis) leaves which were fresh and good without any disease. Data collection methods were carried out through laboratory experiments including extraction, metabolic analysis using LC-HRMS, antibacterial testing using disc diffusion, MIC and MBC. Data were analyzed using ANOVA and Duncan's post-hoc test with a significant value of p<0.05. The results of ethanol extract of getih-getihan leaves showed flavonoids, phenols, triterpenoids, amino acids, fatty acids, and carboxylic acids. The extract is can to inhibit and kill both bacteria, which is indicated by the presence of an inhibition zone, a decrease in absorbance, and no colony growth on the test media. In conclusion, ethanol extract of getih-getihan leaves has antibacterial activity against S. aureus and P. aeruginosa. The implication is that ethanol extract of getih-getihan leaves has the potential to be developed as a natural antibacterial agent that supports alternative treatment against bacterial infections against S. aureus and P. aeruginosa.
Banana Endophytic Fungi Producing Antagonistic, Antioxidant, and Antibacterial Bioactive Metabolites Aji, Oktira Roka; Putri, Diah Asta; Yuliani, Ririn Kholifatu; Ilma, Nur Malika; Astuti, Sutan Nur Chamida Tri
Indonesian Journal of Applied Research (IJAR) Vol. 7 No. 1 (2026): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v7i1.721

Abstract

The increasing prevalence of antibiotic-resistant pathogens and the environmental hazards associated with synthetic agrochemicals have intensified the search for natural bioactive agents. This study isolated and identified endophytic fungi from banana (Musa spp.) and evaluated their antimicrobial and antioxidant activities. Endophytic fungi were isolated from leaf and stem tissues using a surface-sterilization method, followed by culture purification. Antagonistic activity was assessed through dual culture assays, while molecular identification was performed using ITS rDNA sequencing. Five isolates were obtained, and isolate J2 exhibited clear antifungal activity against Fusarium oxysporum. Sequence analysis showed that J2 is closely related to Talaromyces aculeatus. Fungal metabolites were extracted using methanol and ethyl acetate, and the extracts were tested for antioxidant activity (DPPH assay), total phenolic content, and antibacterial activity against Escherichia coli and Bacillus cereus. The methanol extract exhibited stronger antioxidant activity (IC₅₀: 3285.41 ± 80.06 ppm), while the ethyl acetate extract showed higher phenolic content (45.04 ± 9.02 mg GAE/g) and superior antibacterial effects. These results highlight T. aculeatus as a promising natural source of multifunctional bioactive compounds.
Co-Authors Astuti, Sutan Nur Chamida Tri Ilma, Nur Malika Oktira Roka Aji Putri, Diah Asta Salimah, Azizah Zahratus Tufahati, Nadhira