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All Journal EKSAKTA: Journal of Sciences and Data Analysis Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) FORTE JOURNAL Jurnal Pengabdian Masyarakat Permata Indonesia
Hikmah, Uzulul
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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NON-CODING RNA (ncRNA) IN DIABETIC NEPHROPATHY: A REVIEW Fitriani, Hannie; Hikmah, Uzulul; Ferneda, Larysa; Pramundita Ramadani, Arba
FORTE JOURNAL Vol 5 No 2 (2025): Edisi Juli 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v5i2.1446

Abstract

Diabetes Nefropati (DN) merupakan penyebab utama terjadinya end‐stage kidney disease. Studi molekuler menunjukkan ncRNA berperan penting dalam mengatur peradangan ginjal, apoptosis, autofagi, proliferasi sel, dan fibrosis ginjal di DN. Pada penelitian ini dilakukan tinjauan artikel mengenai ncRNA sebagai prospek baru dalam pengembangan diagnosis, prognosis, dan pengobatan untuk DN. Metode penelitian dilaksanakan dengan pendekatan studi literatur yang diperoleh dari penelusuran pada database elektronik pubmed dan google scholar dengan kata kunci “ncRNA and diabetes nephropathy” yang mencakup terkait etiologi, patofisiologi, biomarker. ncRNA yang meliputi miRNA, lncRNA, circRNA berperan dalam progresifitas penyakit DN. Studi mengenai ncRNA sebagai terapi masih dalam tahap pengembangan. Miravirsen dan RG-101 adalah beberapa obat miRNA yang telah diuji klinis, tetapi belum ditemukan obat miRNA yang spesifik untuk DN. Salah satu inovasi terapi yang dikembangkan adalah nanopartikel-miRNA-146a-5p (nano-miR-146a-5p) yang menunjukkan aktivitas penekanan ekspresi inflamasi sitokin yang memiliki efek perlindungan yang terjadi melalui regulasi respon inflamasi dan apoptosis. Pengembangan terapi ncRNA pada DN membutuhkan penelitian dan kajian lebih lanjut, sehingga mampu menjadi pilihan pengobatan DN di masa medatang.
Acute Toxicity Evaluation of Phyllanthus niruri SNEDDS Formulation According to OECD 425 Hikmah, Uzulul; Ramadani, Arba Pramundita; Canastie, Putri Julia; Ma'wa, Nurul Jannatul
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 7, ISSUE 1, April 2026
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol7.iss1.art2

Abstract

A self-nanoemulsifying drug delivery system (SNEDDS) is a preparation that can increase the solubility of poorly soluble compounds, including Phyllanthus niruri. However, increasing solubility and bioavailability carries the risk of increased toxicity. Previous research showed that SNEDDS of Phyllanthus niruri (SNPN) at a dose of 100 mg/kgBW has hepatoprotective activity through decreasing ALT and AST enzyme levels after administering paracetamol at a dose of 3 g/kgBW in rats. However, at a dose of 200 mg/kg, ALT and AST levels increased, indicating potential toxicity. This study aims to determine the LD50 and to conduct histopathological observations of the liver and kidneys following oral administration of SNPN, in accordance with OECD 425 guidelines. Dose determination follows the recommendations of the AOT 425 StatPgm software, which includes the limit test (2000 mg/kg BW) and the main test (175, 550, and 2000 mg/kg BW), with observations made over 14 days. Next, the animals were sacrificed and necropsied to collect the liver and kidney organs for histopathological observation. LD50 determination was performed using AOT 425 StatPgm, and the level of organ damage was assessed using histopathological scoring. The result showed that the LD₅₀ value of SNPN exceeded 2000 mg/kgBW, placing it in category 5 (mild toxicity). Histopathological tests showed varying severity of changes between doses, indicating a toxic effect of SNPNadministration on the microscopic structure of the target organs. In conclusion, SNPN administration has the potential to cause mild acute toxicity, as indicated by the LD50 results and histological changes in the liver and kidneys.
Phytochemical Constituents and Pharmacological Activities of Houttuynia cordata Thunb. as a Phytopharmaceutical: A Narrative Review Triastuti, Asih; Adytia, Juldani; Hikmah, Uzulul; Ananditia, Putri
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.15131

Abstract

Houttuynia cordata Thunb. is a promising medicinal plant recognized for its rich diversity of secondary metabolites, particularly flavonoids and essential oils, that are differentially distributed across its plant organs. This narrative review aimed to critically synthesizes the reported pharmacological activities, specific phytochemical constituents of each organ, molecular mechanisms of isolated bioactive compounds, and contributions of the metabolites produced by associated endophytic microorganisms. Relevant literature was identified through electronic databases including PubMed, Scopus, ScienceDirect, and Google Scholar using the keywords “Houttuynia cordata”, “phytochemical”, “pharmacological activity”, and “secondary metabolites”, from 2015-to 2025.  A broad body of literature published was examined to map the diversity of bioactive compounds, experimental models, and mechanisms of action. The findings reveal that the leaves of H. cordata are rich in flavonoids such as quercetin and rutin, which act as potent antioxidants and immunoprotective agents. The stems and rhizomes are dominated by monoterpenes and volatile ketones exhibiting marked antimicrobial and anti‑inflammatory properties. Preclinical evidence consistently demonstrates antitumor activity via apoptosis induction, multitarget antiviral effects, antidiabetic, and antihyperlipidemic activities as well as anti‑inflammatory actions mediated through the inhibition of TNF‑α and PGE₂ pathways. Antibacterial and anticancer properties are also notably attributable to the secondary metabolites produced by the endophytic microbiota associated with this plant. The phytochemical diversity of H. cordata and its symbiotic endophytes offer promising prospects for the discovery of novel bioactive compounds from Indonesian biological resources. Collectively, H. cordata holds substantial potential as antioxidant, antimicrobial, antivirus, anticancer, antidiabetic, antihyperlipidemic, anti-inflammatory, immunomodulatory, and antiasthma, warranting further investigation as an innovative phytopharmaceutical candidate.
Efektivitas Penyuluhan Kesehatan Terhadap Peningkatan Pengetahuan Manajemen Nyeri pada Warga Padukuhan Gading Wetan Hikmah, Uzulul; Kinasih, Khasnah Nur; Nagari, Nilam Cahaya; Azizah Putri, Marshanda Nur; Ariani, Yolanda Putri; Yarbo, Mufid M.; Oktavia, Meisya Firdha; Iroqi, Adinda Salsabila; Putri, Wahyu Agustin; Putri, Noviana Prasmita Tiara; Wulandari, Suci
Jurnal Pengabdian Masyarakat Permata Indonesia Vol 6 No 1 (2026): Volume 6, Nomor 1 , April 2026
Publisher : Permata Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59737/jpmpi.v6i1.388

Abstract

Pain is an unpleasant sensory and emotional experience resulting from actual or potential tissue damage. Education about pain management is essential for the public to use pain medication wisely and safely. The purpose of this outreach program was to determine differences in knowledge among Gading Wetan residents before and after SIPENA (Your Pain Care Pharmacy) outreach. The research employed a pre-experimental one-group pretest-posttest design, involving 34 respondents, consisting of productive-age residents in RT 03, Padukuhan Gading Wetan. The majority of respondents were aged 18–59 (88%), had secondary education (82%), were housewives (88%), earned below the minimum wage (UMK) (79%), and were married (94%). The Wilcoxon test results showed a significant difference in knowledge levels before and after the outreach (p = 0.001025 < 0.05), indicating that SIPENA outreach was effective in improving community knowledge about pain management. Therefore, it can be concluded that SIPENA outreach is effective in improving community knowledge about pain. It is hoped that there will be cooperation between residents and health workers, especially pharmacists, in the wise and safe use of pain medication
Co-Authors Adytia, Juldani Ananditia, Putri Arba Pramundita Ramadani Ariani, Yolanda Putri Asih Triastuti Azizah Putri, Marshanda Nur Canastie, Putri Julia Ferneda, Larysa Fitriani, Hannie Iroqi, Adinda Salsabila Kinasih, Khasnah Nur Ma'wa, Nurul Jannatul Nagari, Nilam Cahaya Oktavia, Meisya Firdha Pramundita Ramadani, Arba Putri, Noviana Prasmita Tiara Putri, Wahyu Agustin Suci Wulandari Yarbo, Mufid M.