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Retno Priamsari, Margareta
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PENGARUH METODE PENGERINGAN TERHADAP KUALITAS EKSTRAK DAN KADAR FLAVONOID TOTAL EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) Retno Priamsari, Margareta; Mita Susanti, Maria; Harya Atmaja, Andreas
Jurnal Farmasi (Journal of Pharmacy) Vol. 5 No. 1 (2016): Jurnal Farmasi (Journal of Pharmacy), October 2016
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Flavonoids is one active compounds in the Gynura procumbens (Lour.) Merr. leaves for antioxidant, inhibiting of cancer cells, and maintaining liver function. Flavonoid is thermolabile compound and need proper post harvest handling. The purpose of this study is to the determine effect of drying method on the quality of extract and total flavonoids content in ethanolic extract of Gynura procumbens (Lour.) Merr. leaves. This type of research is experimental. Drying methods used in this research are by wind drying under shade place from direct sunlight and oven drying in 40o C temperature. Analysis of total flavonoids content using colorimetric method with AlCl3 complexing compounds and quercetin standard. Standard calibration curve was made 5 series concentrations of 40, 60, 80, 100, and 120 ppm. The absorbance was read at 434 nm wavelength of Uv Vis spectrophotometer. Data obtained in the form of lower levels of flavonoids are analyzed statistically with a pair of independent sample t -test. The results showed if drying methods make a significant different of quality extract and total flavonoids content ethanolic extract of Gynura procumbens (Lour.) Merr leaves. Total flavonoids content with wind drying method is 2.15 ± 0.03% w/w and total flavonoid content with 40oC oven drying method is 1.87 ± 0.01% w/w. The total flavonoid content is counted as quercetin.
Pemanfaatan Limbah Minyak Goreng Bekas dan Bekatul Menjadi Sabun Antiaging Mita Susanti, Maria; Retno Priamsari, Margareta
Jurnal Farmasi (Journal of Pharmacy) Vol. 8 No. 1 (2019): Jurnal Farmasi (Journal of Pharmacy), October 2019
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Used cooking oil and rice bran is waste that has less economic value. The use of cooking oil repeatedly causes the fatty acids contained in the oil to be more saturated. Changes in the nature of cooking oil make cooking oil unfit for use as food because it can cause health effects on the body. Meanwhile, the availability of rice bran which is very abundant and nutrition of rice bran that contains a high antioxidant has not been comparable with its limited utilization. The research objective is to treat used cooking oil waste and rice bran waste to be processed into anti-aging soap products. This was an experimental research with the independent variable is bran soap formula and the dependent variable is the quality characteristics of bran soap which includes organoleptic test, pH, foam power, free alkali and vitamin E. The data were analyzed descriptively by comparing the results of research with SNI 06-3532 -1994. The results showed rice bran soap that meets the quality requirements is formula II, which is obtained results that meet the soap quality requirements in theory which includes solid organoleptic tests, typical odorous rice bran and brown, pH 11 test, 2,28 cm foam power test, acid test 0,46% free fat, 0,1% free alkaline test and positive contain vitamin E.
Skrining Fitokimia dan Aktivitas Penyembuhan Luka Bakar Ekstrak Etanolik Morinda Citrifolia L. pada Kulit Kelinci (Oryctolagus Cuniculus) Retno Priamsari, Margareta; Auly Yuniawati, Noor
Jurnal Farmasi (Journal of Pharmacy) Vol. 8 No. 1 (2019): Jurnal Farmasi (Journal of Pharmacy), October 2019
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Burns are damage to the unit or network components caused by changes in temperature, chemicals, electricity, and radiation. Alkaloid, flavonoid, saponin, and tannin compounds in Noni leaves (Morinda citrifolia. L) have the potential to heal burns. The aim of this study was to determine phytochemical screening and the activity of noni leaf extract to the healing of burns on rabbit skin. This type of research is experimental with a randomized pattern design in one direction. Noni leaf ethanolic extract was obtained by remaseration method using 96% ethanol solvent and phytochemical screening tests. Tests of burns were carried out on 5 male New Zealand strain rabbits. Each part of the rabbit's back skin was divided into 5 treatments, namely positive control (Bioplacenton gel), negative control (vaselin flavum), and ethanolic extract of noni leaf concentrations of 10%, 15%, and 20%. The skin of the back is induced by a 2 cm diameter hot metal plate for 10 seconds until a shallow second degree burn occurs. Burn wound healing parameters include visual observation of physiological mean and reduction in wound diameter for 21 days. The average percentage of wound healing was analyzed by non-parametric statistics with Kruskal-Wallis, followed by Mann-Whitney with a confidence level of 95%. The results showed that the ethanolic extract of noni leaves contained alkaloids, flavonoids, saponins and tannins as well as having burn healing activities. The variation in the concentration of ethanolic extract of noni leaves is 10%; 15% and 20% have no significant effect on the healing of burns.
Uji Aktivitas Antibakteri Ekstrak Etanolik Daun Mengkudu (Morinda Citrifolia L.) Terhadap Bakteri Streptococcus Pyogenes secara In Vitro Retno Priamsari, Margareta; Rokhana, Almira
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020
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Pharyngitis is a disease that is included in the Upper Respiratory Tract Infection (ISPA). The most common bacteria in acute pharyngitis is Streptococcus pyogenes. Plants that have antibacterial properties are noni (Morinda citrifolia L.). This study aims to determine the minimum inhibitory level (MIC) of S. pyogenes antibacterial activity in vitro. Extraction by remaceration method using ethanol 96% solvent. The Kirby-Bauer method for antibacterial testing used BAP media inoculated by means of a spread plate. The treatment group used a positive control (amoxicillin 25 µg); negative control (sterile distilled water); Noni leaf extract with a concentration of 1.25%, 2.5% and 5%. Replication was carried out 3 times. The parameters observed were the inhibition zone formed around the disc paper. The data obtained were analyzed statistically using Kruskall-Wallis followed by Mann-Whitney with a confidence level of 95%. The results showed that the noni leaf extract contained saponins, triterpenoids, tannins and phenols. Noni leaf extract had a significant effect (p≤0.05) on S. pyogenes. The 2.5% concentration had the smallest activity with an average inhibition zone diameter of 5.83 mm.
Co-Authors Auly Yuniawati, Noor Harya Atmaja, Andreas Maria Mita Susanti Rokhana, Almira