Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Madani: Multidisciplinary Scientific Journal
Weguna, Asti Awaliyah
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Physics Public Health Social Sciences Other

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Literature Review: Potensi Senyawa Bahan Alam Sebagai Inhibitor A-Glukosidase Untuk Terapi Diabetes Melitus Melalui Pendekatan Molecular Docking Weguna, Asti Awaliyah; Amin, Saeful
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 8 (2025): September
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.17281128

Abstract

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to insulin resistance. One effective therapeutic strategy is the inhibition of the ?-glucosidase enzyme, which plays a crucial role in carbohydrate breakdown into glucose. This study aims to review the potential of natural compounds as ?-glucosidase inhibitors for diabetes therapy through a molecular docking approach. Literature searches were conducted through PubMed, ScienceDirect, and Google Scholar databases (2020–2025), and eight eligible articles were analyzed. The results revealed that orientin, vitexin, and reserpine from Sonneratia alba, pimaric acid from Michelia champaca, mimopudine from Mimosa pudica, apigenin from Psidium guajava, and spirost-8-en-11-one from Momordica charantia exhibited stronger binding affinities than acarbose. Their interactions with key catalytic residues (Asp215, Glu277, His351, and Asp542) indicate a strong inhibitory potential against ?-glucosidase. These findings suggest that flavonoids, alkaloids, and triterpenoids from medicinal plants possess significant potential as natural ?-glucosidase inhibitors that are safer and more effective. Further in vitro and in vivo studies are recommended to validate their pharmacological activity and safety prior to clinical application.
Co-Authors Saeful Amin, Saeful