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Periyasamy, Kavitha
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics

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Synthesis, Characterization, Anticancer, and Molecular Docking Investigations of Benzothiazole Metal Complexes Periyasamy, Kavitha; Nainamalai, Vijayakumari
Science and Technology Indonesia Vol. 10 No. 4 (2025): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.4.1120-1129

Abstract

The synthesized 2-aminobenzothiazoles based ligand reacted with various transition metal salts were smoothly converted to square planner complexes. The synthesized transition metal complexes are analyzed by using various characterization techniques. Anticancer activity of Schiff base ligand and synthesized metal complexes are examined against human prostate cancer cell line (DU145) MTTassay at different concentration (1, 2, 4, 8, 16, 32, 64, 128, 256, and 512 ug/mL). The IC50 values of metal complexes and free ligand were 16.21 (SBI-Co), 75.98 (SBI-Ni), 25.53 (SBI-Cu), 81.71 (SBI-Zn), and 29.6 (free ligand) ug/mL respectively. Cohasmorepotent against human prostate cancer cell line (DU145). In contrast, the molecular docking study shows, Cu (II) complex has significant inhibition against human 2W3L protein.
Co-Authors Nainamalai, Vijayakumari