Claim Missing Document
Check
Articles

Found 2 Documents
Search

MOLECULAR TYPING OF MULTI DRUG RESISTANCE E.COLI THAT ISOLATES FROM PATIENT WITH URINARY TRACT INFECTIONS IN NAJAF PROVINCE Abdulhadi, Ali M Hussein
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1279

Abstract

Objective: This study aimed to detect the diversity of multidrug-resistant Escherichia coli strains isolated from urinary tract infection (UTI) patients and to assess their potential for biofilm formation. Method: Twenty bacterial isolates were obtained from urine cultures of UTI patients hospitalized at Najaf Teaching Hospital. The isolates were cultured on blood agar and MacConkey's agar, identified using the Vitek 2 system, and subjected to antibiotic susceptibility testing with the AST card. Genetic diversity among the isolates was further analyzed using ERIC-PCR. Results: The findings revealed high levels of antibiotic resistance among the E. coli isolates: 100% resistance to amoxicillin and ampicillin, 90% to ceftriaxone and ceftazidime, 70% to amikacin, and 55% to meropenem. ERIC-PCR results demonstrated genetic variation among isolates, which were grouped into five distinct clusters with similarity indices ranging from 40% to 90%. Novelty: This study provides insight into the alarming resistance patterns and genetic diversity of uropathogenic E. coli, underlining the critical need for tailored antibiotic stewardship and further investigation into their biofilm-forming capabilities in clinical settings.
COVID-19–RELATED LUNG INJURY: A HISTOPATHOLOGICAL OVERVIEW Alkhirsan, Zainab M Jawad; Alyasiry, Esraa A.; Abdulhadi, Ali M Hussein
Journal of Medical Genetics and Clinical Biology Vol. 3 No. 1 (2026): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v3i1.1601

Abstract

Objective: To provide a comprehensive review of the key histopathological features associated with COVID-19–related lung injury and to clarify the extent of vascular and inflammatory involvement in the disease. Method: A literature review analyzing reported histopathological findings in COVID-19 lung specimens, comparing them with other viral infections such as H1N1 influenza, and correlating them with clinical and radiological data. Results: Findings consistently highlight diffuse alveolar damage (exudative and proliferative phases), type II pneumocyte hyperplasia, squamous metaplasia, intra-alveolar hemorrhage, microthrombosis, and occasional osseous metaplasia. Additional observations include inflammatory infiltrates, endothelial injury, and cytokine-related damage (e.g., IL-6 upregulation). COVID-19 shows more extensive alveolar and vascular involvement than many other viral infections, though findings vary across patients and comorbidities. Novelty: The review underscores that although several histopathological features overlap with other viral pneumonias, the severity of vascular injury and the complexity of the inflammatory response in COVID-19 distinguish it. It also stresses the diagnostic value of integrating histopathological, clinical, and radiological evidence to better understand disease pathogenesis.