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All Journal Jurnal Biologi Tropis Jurnal Ilmu Kedokteran dan Kesehatan
Pramudiantara, Gede Naradhea
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Nail Disorders as Manifestations of Systemic Diseases Ramdhini, Tisya Nasywa; Setiasari, Febi Jian; Salsabila, Adilah Nur; Pramudiantara, Gede Naradhea; Nabila S., Aqilla Nasywa; Ilham, Muhammad Fadani; Josafat, Anom
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10308

Abstract

Nails are often overlooked in clinical examinations, despite their ability to provide important information regarding systemic health conditions. Changes in nail morphology, color, and growth frequently reflect underlying metabolic, hematological, autoimmune, infectious, and neoplastic disorders. This article aims to comprehensively review various nail abnormalities as manifestations of systemic diseases. The method used was a narrative literature review with article searches conducted through PubMed and Google Scholar databases using the keywords nail abnormalities, systemic diseases, nail manifestations, and clinical signs. Articles published between 2015 and 2025 were selected based on relevance, with inclusion criteria consisting of clinical studies, case reports, and reviews discussing the association between nail abnormalities and systemic diseases, while excluding literature that focused solely on local nail disorders without systemic relevance. The results indicate a range of nail abnormalities associated with systemic diseases, including splinter hemorrhage in infective endocarditis and vasculitis, clubbing finger in lung cancer and cyanotic congenital heart disease, subungual hyperkeratosis in psoriasis and onychomycosis, nail bed pallor in chronic anemia, koilonychia in iron deficiency anemia, onychomycosis in diabetes and immunodeficiency, as well as yellow nail syndrome related to lymphatic dysfunction, respiratory disorders, and autoimmune diseases. Other manifestations such as leukonychia, Mees’ lines, Terry’s nails, half-and-half nails, and Beau’s lines were also identified in metabolic disorders, renal disease, and toxin exposure. In conclusion, nail examination can serve as a valuable non-invasive method in detecting systemic diseases. Early identification of nail changes has the potential to assist clinicians in establishing diagnoses, accelerating interventions, and improving the quality of patient management.
The Role of Molecular Biomarkers in the Diagnosis and Prognosis of Brain Infections Salsabila, Adilah Nur; Ramdhini, Tisya Nasywa; Pramudiantara, Gede Naradhea
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10476

Abstract

Brain infections are among the most severe neurological disorders, with high morbidity and mortality. Conventional diagnostic approaches often face limitations in sensitivity, specificity, and time efficiency. Advances in molecular biotechnology have introduced molecular biomarkers as valuable tools for improving diagnostic and prognostic precision. This literature review, based on publications from 2015 to 2024 retrieved from PubMed, ScienceDirect, ProQuest, SpringerLink, and Google Scholar, aims to explore the role of molecular biomarkers in brain infections. Pathogen based biomarkers such as Polymerase Chain Reaction (PCR), Loop Mediated Isothermal Amplification (LAMP), and multiplex assays enable rapid and specific pathogen detection, while host response biomarkers, including cytokines such as IFN-γ, TNF-α, and IP-10, as well as ferritin and lactate levels in cerebrospinal fluid, reflect neuroinflammatory processes. The integration of pathogen detection and host response biomarkers enhances diagnostic accuracy, facilitates individualized therapeutic strategies, and contributes to improved clinical outcomes in neuroinfectious diseases.
Diagnosis And Comprehensive Management Of Thyroid Storm: A Literature Review Husodo, Dewi Puspitorini; Pramudiantara, Gede Naradhea; Wibawa, Galang Edi; Suryantarini, Ni Wayan Puspa Wijaya; Widad, Najwa; Bramantyo, Rofi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 4 (2026): Volume 13 Nomor 4
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i4.23240

Abstract

Thyroid storm is a life-threatening endocrine emergency characterized by severe hypermetabolism and multiorgan dysfunction with mortality rates ranging from 10–30%. Delayed diagnosis and inappropriate management significantly contribute to poor clinical outcomes. This study is a literature review conducted through systematic searches in PubMed, Google Scholar, Wiley, Springer, and ScienceDirect databases for articles published between 2015 and 2025 using keywords “thyroid storm,” “hyperthyroidism,” “emergency,” “diagnosis,” and “management.” A total of 30 relevant articles, including case reports, cohort studies, and original research, were analyzed descriptively. The findings show that thyroid storm occurs in approximately 1–2% of hospitalized hyperthyroid patients, with global mortality reaching 20–30% and 8–25% in Indonesia. Early diagnosis using the Burch-Wartofsky Point Scale (score 45), combined with Japanese Thyroid Association criteria, improves diagnostic accuracy and facilitates prompt treatment. Initial management focuses on ABCDE stabilization, fluid resuscitation, and supportive care, followed by pharmacological therapy including antithyroid drugs (propylthiouracil or methimazole), iodine, beta-blockers, and corticosteroids. In refractory cases, plasmapheresis may be required, while definitive therapy such as thyroidectomy or radioiodine is performed after achieving euthyroid status. Thyroid storm requires rapid recognition and a structured, multidisciplinary management approach, and integration of validated diagnostic tools with comprehensive treatment strategies is essential to improve patient outcomes and reduce mortality.
Co-Authors Bramantyo, Rofi Husodo, Dewi Puspitorini Ilham, Muhammad Fadani Josafat, Anom Nabila S., Aqilla Nasywa Ramdhini, Tisya Nasywa Salsabila, Adilah Nur Setiasari, Febi Jian Suryantarini, Ni Wayan Puspa Wijaya Wibawa, Galang Edi Widad, Najwa