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Puspita Tanjung, Yenni
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Optimasi Formula Sediaan Losion Ekstrak Bunga Rosella (Hibiscus sabdariffa L.) dengan Box-Behnken Design Shofiani, Della; Puspita Tanjung, Yenni; Akmal, Tubagus
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 1 (2025): Jurnal Farmasi (Journal of Pharmacy), April 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/2n52eb47

Abstract

The extract of roselle flowers contains flavonoid and phenolic components, which function as antioxidants that inhibit free radicals, proving beneficial in avoiding skin degeneration. The antioxidant properties of roselle flowers can be included into cosmetic compositions, including lotions. This study aims to create an optimal lotion formulation by adjusting the quantities of the emulsifiers Olivem®900, Cetearyl alcohol, and TEGO®Care 165. The base formula was optimized using the Box-Behnken Design as an experimental framework, facilitated by Design-Expert version 13.05.0 software. The evaluated response factors comprised pH, viscosity, and spreadability. The formulation was maintained at ambient temperature for 28 days and subsequently evaluated using GraphPad Prism version 10.4.0 software. The base optimization method utilized 15 recommended formulations, determining that the optimal base formula comprises 1.6% Olivem®900, 4.2% Cetearyl alcohol, and 9% TEGO®Care 165, achieving a desirability value of 1. The optimal formula layer derived was the foundation of the lotion including roselle flower extract. The results of the stability test analyzed statistically using the t-test showed differences in the pH test which had a significant effect (p<0.05) between the optimum formula of lotion base and the optimum formula of rosella flower extract lotion, but had no significant effect (p>0.05) on the viscosity test and the spreadability test. The results of the analysis using the t-test showed a significance value of p>0.05, which means that the preparation is statistically stable during the storage period.
Formulasi dan Evaluasi Tablet Hisap Ekstrak Elderberry (Sambucus nigra L.) menggunakan Metode Granulasi Kering Sulistiani, Ine; Gitalis Kustiawan, Mayas; Qiroatul Fatihah, Naila; Friza Puspita, Nazwa; Rosita, Nur; Puspa Sari, Pungki; Ahista Qolbi, Raihan; Azzahra, RD Salma; Sugiharti Murni, Resha; Puspita Tanjung, Yenni
Jurnal Medika Farmaka Vol 3 No 2 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i2.71

Abstract

Elderberry fruit (Sambucus nigra L.) is known to contain flavonoids, anthocyanins, vitamin C and hasantioxidant activity that has the potential to increase immunity and help relieve symptoms of upper respiratorytract infections. This study aims to formulate elderberry extract-based lozenges. The lozenges were formulatedusing the dry granulation method with variations in amprotab concentration to see its effect on tablet quality.Evaluation was carried out on the physical properties of the granules and the physical quality of the resultingtablets. The results showed that formula F2 (amprotab 16.67%) showed the characteristics closest to optimal.The evaluation of the granules had a flow rate of 18.16 g/second, an angle of repose of 20.44°, acompressibility of 10.49%, and a hausner ratio of 1.11, which means it showed good flow properties. Thetablets of this formula have a disintegration time of 9 minutes 16 seconds, friability of 0.92%, hardness of 4.5kg, average weight of 602 mg, diameter of 1.21 cm, and thickness of 0.525 cm. Parameters as uniformity ofweight and hardness of the tablets do not meet the Pharmacopoeia standards. Therefore, further optimization isneeded in the molding process and adjustment of the excipient ratio to obtain lozenges with consistent qualityand according to standards. In conclusion, the formulation of lozenges with elderberry powder has the prospectto be further developed, with formulation optimization to improve the quality of the tablets to meet all qualitystandards.Keywords: amprotab, mannitol, elderberry extract, lozenge
Co-Authors Ahista Qolbi, Raihan Akmal, Tubagus Azzahra, RD Salma Friza Puspita, Nazwa Gitalis Kustiawan, Mayas Nur Rosita Puspa Sari, Pungki Qiroatul Fatihah, Naila Shofiani, Della Sugiharti Murni, Resha Sulistiani, Ine