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All Journal Menara Perkebunan MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation
Ikram Maulana
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Agriculture, Biological Sciences & Forestry Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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THE RELATIONSHIP BETWEEN SOCIAL MEDIA USE AND SLEEP DISORDERS IN ADOLESCENTS Muhammad Muflih Maulidan; Mutia Avila Vellani; Ikram Maulana; Azzahra Puti Adama; Fuller, M.Hum
MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Vol. 6 No. 3 (2025): September
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59733/medalion.v6i3.232

Abstract

This study analyzes the relationship between social media use and sleep disorders among adolescents in Indonesia. Through a meta-analysis approach of three main studies, this study examined the causal mechanisms, predisposing factors, and health implications of social media dependence. The results showed a consistent significant association between social media intensity and decreased sleep quality in adolescents, with an average of 69.3% being active users and 65.3% experiencing poor sleep quality. Statistical analysis revealed a strong correlation (coefficient of 0.646) and a significant relationship (p-value <0.001). These findings underscore the urgency of digital health education and structured interventions to reduce the negative impact of social media on adolescent sleep health.
Reference gene validation and differential expression of Psy and ACCase in oil palm with contrasting oil and carotene profiles at different ripening stages Fauziatul Fitriyah; Ikram Maulana; Masna Maya Sinta; Rizka Tamania Saptari; Irma Kresnawaty; Heri Andriwan Siregar; Imron Riyadi
E-Journal Menara Perkebunan Vol. 94 No. 1 (2026): 94(1), 2026
Publisher : INDONESIAN RESEARCH INSTITUTE FOR BIOTECHNOLOGY AND BIOINDUSTRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/iribb.jur.mp.v94i1.679

Abstract

Reliable normalization and accurate quantification are essential for gene expression studies in oil palm mesocarp. This study assessed three candidate reference genes (Actin, GAPDH, and EF1α) for stability using four algorithms (ΔCt, BestKeeper, NormFinder, and GeNorm). Actin was consistently identified as the most stable single housekeeping gene (HKG) (stability value 0.021), while the combination of GAPDH and EF1α provided the most stable normalization pair (stability value 0.017), supporting their use as internal controls for normalization. Normalized expression analysis of two key biosynthetic genes, acetyl-CoA carboxylase (ACCase) and phytoene synthase (Psy), was conducted in contrasting phenotypes differing in oil yield and carotene content. The high-yielding, high-carotene genotype displayed lower ΔCt values for both ACCase (4.67 vs. 6.19) and Psy (4.75 vs. 5.26), corresponding to 2.86-fold and 1.42-fold higher expression, respectively. These expression differences aligned closely with phenotypic outcomes, as the superior traits achieved a 40.8% increase in oil yield and a 155.3% increase in carotene content. Expression patterns showed stage-specific specialization: ACCase was upregulated during the unripe stage, enhancing fatty acid biosynthesis, while Psy was most differentially expressed during ripening, coinciding with carotenoid accumulation. Together, these findings suggest that transcript abundance of oil and carotenoid pathways may be coordinated in elite oil palm and provide a framework for linking gene expression with metabolic output, which may inform future efforts to improve oil yield and quality.
Co-Authors Azzahra Puti Adama Fauziatul Fitriyah Fuller, M.Hum Heri Andriwan Siregar Imron RIYADI Irma KRESNAWATY Masna Maya SINTA Muhammad Muflih Maulidan Mutia Avila Vellani Rizka Tamania Saptari