Putri, Pionera Seconda Giyanti
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Tandem peptide lipid CRISPR-Cas9 complex combating APP and APOE4 gene abnormality in Alzheimer's disease Rahmanto, Ilham; Cahyono, Maulana Bagus Adi; Khatimah, Husnul; Nugraningrum, Rahmi; Putri, Pionera Seconda Giyanti; Sahiruddin, Nurul Zulfa; Rahmaniah, Nabila; Romadhon, Pradana Zaky
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.16054

Abstract

Alzheimer's attacks 24 million global population and dominates 60-80% of existing cases of dementia. It causes the accumulation of beta-amyloid (Aβ) plaques in the hippocampus and entorhinal cortex, resulting in decreased mass from the brain. Recent studies have shown that the manifestation of this disease is due to an overaccumulation of abnormal Aβ protein due to abnormalities in the APP and APOE4 genes. Point mutations in the APP gene will create the toxic form of Aβ protein, namely Aβ42, and the toxic APOE4 gene will accelerate the onset of Aβ42 deposition and pro-inflammatory activity that exacerbates the degenerative process of the brain. Gene editing as a potential definitive therapy was recently a concern by researchers. CRISPR-Cas9 repairs the APP gene and substitutes the APOE4 gene with APOE3 by modifying the gene's DNA sequence. Nano complex CRISPR-Cas9 tandem peptide lipid is a model for clinicians to target brain nerve cells. In vivo research on an Alzheimer's mouse model proved the potential of nano-complex-based peptides as carriers of CRISPR-Cas9 in brain nerve cells. This engineering technology offers satisfactory results with high precision, minimal side effects, and a relatively low price for long-term therapeutic effects and even a lifetime.
Hubungan Usia dan Kepuasan Saat Proses Discharge Planning dengan Kunjungan Ulang Pertama Nifas pada Ibu Nifas dengan Preeklampsia di RS Kota Surabaya Anis, Wahyul; Jayanti, Ratna Dwi; Putri, Pionera Seconda Giyanti; Nofintiyani, Melsa Ana
Malahayati Nursing Journal Vol 8, No 3 (2026): Volume 8 Nomor 3 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v8i3.24291

Abstract

ABSTRACT The postpartum period was a period of physical and psychological adaptation of the mother's body after childbirth, which carries a high risk of morbidity and even death. Age was an important consideration in providing care. Discharge planning is part of healthcare management and can contribute to preparing home care. Patient satisfaction during discharge planning is expected to improve maternal compliance with postpartum follow-up visits. The study aims to analyze the relationship between age and patient satisfaction during discharge planning with the first postpartum follow-up return visit (KF2) at Surabaya City Hospital. This study used a quantitative cohort design involving 37 postpartum women with preeclampsia. Statistical analysis used the chi-square/Fisher exact test when the chi-square requirement was not met. The result is the majority of postpartum women (89.19%) attended the KF2 postpartum visit. The Fisher exact test revealed a relationship between age (p-value 0.001) and patient satisfaction during discharge planning (p-value 0.009) and the first postpartum follow-up visit (KF2) at Surabaya City Hospital. The conclusion is Age and patient satisfaction during discharge planning are factors related to compliance with the first postpartum follow-up visit (KF2), so it is important for providers to pay attention to age and the implementation of discharge planning in providing health services to postpartum mothers, especially those with preeclampsia. Keywords: Maternal Age, Satisfaction, Discharge Planning, Follow Up Visit Postpartum, Health Services.  ABSTRAK Masa nifas adalah masa adaptasi tubuh ibu baik fisik maupun psikologis setelah persalinan yang memiliki risiko besar terjadinya kesakitan sampai kematian. Usia merupakan hal penting diperhatikan dalam memberikan perawatan. Discharge planning adalah bagian dari manajemen pelayanan kesehatan yang dapat berkontribusi dalam menyiapkan perawatan di rumah. Kepuasan pasien saat discharge planning diharapkan dapat meningkatkan kepatuhan ibu dalam kunjungan ulang nifas. Penelitian bertujuan untuk menganalisis hubungan antara usia dan kepuasan pasien saat discharge planning dengan kunjungan ulang pertama nifas (KF2) di Rumah Sakit Kota Surabaya. Penelitian menggunakan metode studi kuantitatif desain kohort dengan melibatkan 37 ibu nifas dengan preeklampsia. Analisis statistik menggunakan uji statistik chi-square/ fisher exact ketika syarat chi square tidak memenuhi. Hasil penelitian adalah sebagian besar ibu nifas melakukan kunjungan nifas KF2 (89,19%). Berdasarkan hasil uji fisher exact menjelaskan bahwa terdapat hubungan antara usia (p value 0,001) dan kepuasan pasien saat discharge planning (p value 0,009) dengan kunjungan ulang pertama nifas (KF2) di Rumah Sakit Kota Surabaya. Kesimpulan penelitian adalah usia dan kepuasan pasien saat discharge planning merupakan faktor yanag berhubungan dengan kepatuhan kunjungan ulang pertama nifas (KF2) sehingga penting bagi provider memperhatikan usia dan implementasi discharge planningdalam memberikan pelayanan kesehatan pada ibu nifas khususnya dengan preeklampsia. Kata Kunci: Usia Ibu, Kepuasan, Perencanaan Pemulangan, Kunjungan Ulang Nifas, Pelayanan Kesehatan.