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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Prosiding University Research Colloquium
Kania, Yulia Intan
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Humanities Computer Science & IT Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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COMPARISON OF GRAM-BACTERIAL RESISTANCE PATTERNS OF PNEUMONIA IN THE ELDERLY AND NON-ELDERY Mahmuda, Iin Novita Nurhidayati; Dewi, Listiana Masyita; Jatmiko, Safari Wahyu; Faizah, Ishmah Nur; Kania, Yulia Intan; Affifah, Fathiyya Noor; Prasetyo, Andri Sugeng
Prosiding University Research Colloquium Proceeding of The 19th University Research Colloquium 2024: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Pneumonia is an infectious disease of the lungs caused by various microorganisms that cause inflammation of the lung parenchyma. This infectious disease is more likely to affect elderly patients. Most of the microorganisms that cause pneumonia are bacteria, both gram-positive and gram-negative bacteria. The main management for patients with pneumonia is to use antibiotic therapy. The irrational use of antibiotics can increase the occurrence of antibiotic resistance. This study aimed to compare the resistance patterns of Gram-positive and Gram-negative bacteria causing pneumonia in elderly and non-elderly patients. This study used a descriptive method with secondary data in the form of medical record data and antibiotic sensitivity test data. based on this study, it was found that the bacteria that caused pneumonia were mostly gram-negative bacteria. The most common gram-negative bacteria was Klebsiella pneumoniae, while the most common gram-positive bacteria was Streptococcus sp. The results of antibiotic sensitivity tests on gram-positive bacteria showed that the majority were resistant to fluoroquinolones, namely Ciprofloxacin (64%), Levofloxacin (59%). Meanwhile, gram-negative bacteria were mostly resistant to Ampicilin (84%) and Cefadroxil (83%). Conclusion: The bacteria that cause pneumonia, both gram-positive and gram-negative, experienced antibiotic resistance to the tested antibiotics. The selection of antibiotic therapy can be adjusted according to the causative bacteria and their resistance patterns.Keywords: Pneumonia; Antibiotic resistance pattern; Gram-positive bacteria; Gram-negative bacteria
Pola Resistensi Bakteri Penyebab Ulkus Diabetikum terhadap Antibiotik di Salah Satu Rumah Sakit Swasta di Surakarta Mahmuda, Iin Novita Nurhidayati; Rosyidah, Devi Usdiana; Prakoeswa, Flora Ramona Sigit; Kania, Yulia Intan; Faizah, Ishmah Nur; Afifah, Fathiyya Noor; Prasetyo, Andri Sugeng
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 1 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i1.85091

Abstract

Infeksi ulkus diabetikum termasuk sebuah komplikasi lanjutan dari diabetes melitus yang masih terus meningkat kasusnya. Apabila belum ditangani secara cepat akan memperlaju tingkat keparahan infeksi. Tujuan penelitian ini untuk mengetahui pola resistensi bakteri penyebab ulkus diabetikum terhadap antibiotik pada pasien ulkus diaetikum. Jenis penelitian menggunakan deskriptif observasional. Sistem kompak VITEK 2 digunakan untuk identifikasi bakteri dan pengujian kerentanan antimikroba sesuai petunjuk. Kemudian, suspensi untuk inokulasi kartu AST GP 71 yang digunakan untuk uji kerentanan obat dilakukan dengan memindahkan 280µL suspensi kultur dari suspensi pertama ke dalam 3mL larutan garam steril untuk memperoleh kekeruhan akhir 10 CFU/mL. Hasil penelitian didapatkan sebanyak 11 jenis bakteri teridentifikasi dari spesimen pus, didapatkan hasil bahwa Staphylococcus aureus dan Eschericia coli mendominasi bakteri terbanyak.
Co-Authors Affifah, Fathiyya Noor Afifah, Fathiyya Noor Devi Usdiana Rosyidah Faizah, Ishmah Nur Flora Ramona Sigit Prakoeswa Iin Novita Nurhidayati Mahmuda Listiana Masyita Dewi Prasetyo, Andri Sugeng Safari Wahyu Jatmiko