This research aims to examine the entrepreneurial interest of students at the Faculty of Economics, Bung Hatta University, and the factors influencing it. And to estimate whether they will become MSME actors in West Sumatera. This research was conducted on 241 students who have taken an entrepreneurship course. The tests conducted were descriptive statistics, classical assumptions, and multiple regression with the help of SPSS software. The results of the descriptive statistics of the tested variables show that entrepreneurial interest, desire to be a boss, desire to have and manage one's own finances, environmental support, innovation, self-esteem, and desire to overcome personal challenges are very high, and the leadership, flexibility, and innovation they possess are quite high. The independent variables explain 23.8% of the variation in the dependent variable. Simultaneously, the variables of self-esteem, personal challenges, desire to be a boss, innovation, leadership, flexibility, finance, and environment have a positive and significant impact on entrepreneurial interest. Partially, the variables of personal challenges, desire to be a boss, finance, and environment have a positive and significant impact on entrepreneurial interest, but self-esteem, innovation, leadership, and flexibility have a positive but not significant impact on entrepreneurial interest.