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All Journal Jurnal Plastik Rekonstruksi Jurnal Rekonstruksi dan Estetik
Widjaja, Febe Alodia
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Civil Engineering, Building, Construction & Architecture Medicine & Pharmacology Other

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Patients’ Profile of Cleft Lip and Palate : 3 Years Evaluation at Surabaya CLP Center Foundation Widjaja, Febe Alodia; Saputro, Iswinarno Doso
Jurnal Plastik Rekonstruksi Vol. 11 No. 2 (2024): (2024) Jurnal Plastik Rekonstruksi
Publisher : The Lingkar Studi Bedah Plastik Foundation and is affiliated with the Department of Plastic Surgery, Faculty of Medicine, Universitas Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v11i2.381

Abstract

Introduction: Cleft lip and cleft palate are the most common birth defects affecting newborns, yet their variability across each geographic origin is not clearly understood. This study aims to investigate the CL/P prevalence, profile, and corrective surgery timing in Surabaya, Indonesia.Method: This retrospective research used a descriptive method by collecting medical data records from the Surabaya CLP Center Foundation from January 2021 to December 2023, which related to sociodemographic problems, clinical features, and management timing were then statistically analyzed.Results: A total of 495 patients underwent cleft surgery, of which 59.4% were male and 40.6% were female. The most common type of Craniofacial Cleft observed is Combination Cleft Lip and Palate “CLP” (71.1%). CLP is more common in male patients than in female patients (43.4% vs. 27.7%); while CL is more common among males (14.1% vs. 9.7%) and CP is more common in females (3.2% vs. 1.8%). Significantly, complete clefts (72.9%) were more common than the incomplete clefts (27.1%). Unilateral clefts were more common than bilateral clefts (76.2% vs 18.8%). It was observed that only 22% of patients had a family history of CL/P. Overall, 74,9% of patients underwent corrective surgery within the right period.Conclusions: The data shows that most patients tended to seek medical advice and treatment at appropriate times, suggesting a high awareness of CLP as the result of proactive education and social outreach by the charity institution. Further investigations using data from other institutions are suggested to conclude the CLP management in Surabaya entirely.
THERAPEUTIC POTENTIAL OF SNAIL MUCUS IN WOUND HEALING : A SYSTEMATIC REVIEW AND META-ANALYSIS Widjaja, Febe Alodia; Saputro, Iswinarno Doso; Asmaradianti, Aryunidya; Sindhu, Florencia Christina; Fabian, Pascalis; Irsyan Baginda Maulana
Jurnal Rekonstruksi dan Estetik Vol. 10 No. 2 (2025): Jurnal Rekonstruksi dan Estetik, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jre.v10i2.72008

Abstract

Highlights: Snail mucus extract significantly improves wound healing rates compared to standard treatments. A meta-analysis of randomized controlled trials (RCTs) showed a statistically significant effect (MD = -3.21%, P < 0.00001). The bioactive compounds in snail mucus promote collagen production and reduce inflammation. Abstract Introduction: Wound healing is a fundamental biological process comprising four sequential and overlapping phases: hemostasis, inflammation, proliferation, and remodeling. The successful restoration of tissue integrity requires that these phases proceed in the correct order and within an appropriate temporal framework. Proteins are indispensable to this process, as they mediate tissue growth, cellular renewal, and reparative mechanisms. Snail mucins, a class of large glycosylated proteins, have been reported to facilitate wound healing by stabilizing protein structures, modulating solubility and viscosity, and enhancing cell–cell recognition. In light of these properties, we conducted a meta-analysis of randomized controlled trials (RCTs) to assess the therapeutic efficacy of snail mucus extract in promoting wound repair. Method: RCTs on snail mucus extract for wound healing were identified through searches of PubMed, ProQuest, Web of Science, ScienceDirect, Scopus, EBSCOHost, and ClinicalTrials.gov. The review adhered to PRISMA guidelines, applied the PICO framework, and assessed study quality using the JADAD scale. Result: A total of 60 rats from three RCTs conducted between 2021 and 2023 were included in the meta-analysis. The findings demonstrated that the snail mucus group exhibited a significantly improved wound healing rate compared to the control group (MD = -3.21%, 95% CI: -3.72 to -2.69%, P < 0.00001). Conclusion: Snail mucus extract has been shown to significantly accelerate wound healing in animal models; however, further clinical studies are required to confirm its therapeutic efficacy in humans.
Co-Authors Asmaradianti, Aryunidya Fabian, Pascalis Irsyan Baginda Maulana Iswinarno Doso Saputro Sindhu, Florencia Christina