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All Journal Jurnal Sain Veteriner Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JBN (Jurnal Bedah Nasional) Jurnal Plastik Rekonstruksi JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Rekonstruksi dan Estetik MEDICINUS Medical Sains : Jurnal Ilmiah Kefarmasian Folia Medica Indonesiana
Iswinarno Doso Saputro
Departemen Bedah Plastik Rekonstruksi Dan Estetik, Fakultas Kedokteran, Universitas Airlangga/RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary Other

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Profil Klinik Pasien dengan Ulkus Dekubitus di RSUD Dr. Soetomo Surabaya Huvi, Indira; Saputro, Iswinarno Doso; Murtiastutik, Dwi
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 2 (2019): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (34.155 KB) | DOI: 10.33533/jpm.v13i2.927

Abstract

Decubitus ulcer or known as pressure ulcer is one of the types of chronic wounds that are often found. The incidences of decubitus ulcers are quite high in some countries, including in Indonesia. The main cause of decubitus ulcer is, long term immobilization, as example the total bedrest patients. Decubitus ulcers are associated with some diseases that causes immobilization such as spinal cord injury, lower extremity fracture, stroke, etc. The aim of this research is to identify the data of patients with decubitus ulcer in RSUD Dr. Soetomo period 1 January 2017 ? 31 December 2017. This research is a descriptive retrospective by collecting 148 secondary data from the medical records in RSUD Dr. Soetomo period 1 January 2017 ? 31 December 2017. Decubitus ulcer mostly be found in elderly (>65 years old) and was dominated by women. The most common disease that associated with decubitus ulcer is trauma (spinal cord injury and lower extremity fracture). The onset of decubitus ulcer in RSUD Dr. Soetomo patients is mostly more than 7 days. The prognosis and outcome of patients with decubitus ulcer are mostly dubia, with 2nd degree of ulcer and in alive condition.
Immune Response to Burn Injury: Hyperinflammation and Immunosuppression Septin Mauludiyana; Aryati; Yoes Prijatna Dachlan; Iswinarno Doso Saputro; Muhaimin Rifa’i
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15936

Abstract

Burn is an injury to the skin or other tissue. Mostly, it caused by contacting with hot liquids, solids, and flames. The important thing that should be consider in burn incident is the severity of burn and it based on the depth and area of the burn injury. The severity of burns will cause differences of pathophysiological responses. This was a literature review study. Various articles were collected from online database including reports, journals, and published in the last 10 years. The articles were from the scholar journals. The systemic inflammatory response in severe level of burns was not given good response to disappear of lesion burn and initiating tissue repair. Moreover, it was given an organ failure to the patient. The body responded to this incident by releasing antiinflammatory mediators. This response is very strong and prolonged, so it caused immunosuppression and increase the risk of secondary infection to the patients. Burns affects the patient’s immune system. The ratio between pro and antiinflammatory mediators are determining the patient’s subsequent status.
The Role of IL-27 as An Anti-Inflammatory in A Severe Burns Model Waode Fifin Ervina; Aryati; Yoes Prijatna Dachlan; Iswinarno Doso Saputro
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15995

Abstract

Efektifitas perlakuan awal Tretinoin 0,1% Topikal pada Proses Penyembuhan di Luka Insisi pada Mencit (Mus musculus) Iswinarno Doso Saputro; Hesty Aulia Palupi; Wiwik Misaco Yuniarti
Jurnal Sain Veteriner Vol 36, No 2 (2018): Desember
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (9452.348 KB) | DOI: 10.22146/jsv.41152

Abstract

Tretinoin has an important role in wound healing process include improve fibroplasia and collagen synthesis, maintening humoral immunity, and neutralize steroid effect.Epithelization  and fibroblast proliferation were very important event in wound healing process. The aims of this study were studying epithelization and fibroblas proliferation on incision wound healing process using pre treatment of  Tretinoin 0,1%  topically on mice. This research used 24 male mice, 3 month of age, with 150 -180 gram of body weight. The mice were divided into 2 groups, control group (K) and treatment group (P). The control group was a group of mice with an incision wound, while the treatment group was a group of mice with an incision wound that received a pretreatment of Tretionin of 0.1% topically. Each group was divided into 2 sub groups K4, K7, P4, P7 based on time of samples collecting. K4 and P4 were examined at  day 4, while K7 and P7 were examined at day 7. Epithelialization was observed by measuring the length of the epithelial incision area, whereas fibroblast proliferation was performed by counting the number of fibroblasts in five field of view on histopathologic skin preparations processed by HE staining.In this study,pretreatment of Tretinoin 0,1%  topically can increase epithelialization and number of fibroblast significantly (p<0,05).This increase may be due to 1% Tretinoin in the tissues to induce keratinocyte basal proliferation including its migration to the skin surface via retinoic acid receptors ( RARδ)Pretreatment of Tretinoin 0,1% topically can increased epithelialization and number of fibroblast on incision wound healing process of albino rats
Pengaruh Pemberian Ekstrak Jahe Merah (Zingiber officinale var. rubrum) terhadap Jumlah Sel Makrofag dan Pembuluh Darah pada Luka Bersih Mencit (Mus musculus) Jantan (Penelitian Eksperimental pada Hewan Coba) Rahel Yuana Sadikim; Willy Sandhika; Iswinarno Doso Saputro
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 2 (2018): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (329.462 KB) | DOI: 10.20473/bikk.V30.2.2018.121-127

Abstract

Latar Belakang: Jahe merah (Zingiber officinale var. rubrum) telah digunakan sebagai obat tradisional khususnya menyangkut penyembuhan luka karena kandungan oleoresin dan minyak atsiri yang tinggi. Namun penjelasan secara ilmiah masih belum banyak diteliti. Proses penyembuhan luka sangat dipengaruhi oleh jumlah makrofag dan pembuluh darah, sehingga peneliti tertarik untuk mengetahui pengaruh pemberian ekstrak jahe merah terhadap jumlah sel makrofag dan pembuluh darah pada luka. Tujuan: Membuktikan bahwa ekstrak jahe merah dapat menurunkan jumlah makrofag dan meningkatkan jumlah pembuluh darah pada luka bersih mencit jantan. Metode: Penelitian analitik eksperimental dengan the post test only control group design. Luka bersih pada 32 subjek dibagi dalam 4 kelompok. Kelompok pertama diberi konsumsi aquades steril secara oral selama 3 hari dan kelompok kedua selama 5 hari. Kelompok ketiga diberi ekstrak jahe merah (50 mg/kg bb) secara oral selama 3 hari dan kelompok keempat selama 5 hari. Preparat jaringan kulit dibuat menjadi slide histologi. Slide diamati dengan mikroskop pembesaran 400x dan graticulae. Hasil penghitungan makrofag dan pembuluh darah dibandingkan dengan uji t-2 sampel bebas. Hasil: Jumlah makrofag kelompok perlakuan lebih sedikit dibanding kontrol pada hari ke-3 (p=0,008) namun tidak signifikan pada hari ke-5 (p=0,409). Jumlah pembuluh darah kelompok perlakuan dibanding kontrol tidak signifikan pada hari ke-3 (p=0,721) dan ke-5 (p=0,365). Simpulan: Ekstrak etanol jahe merah dapat menurunkan jumlah sel makrofag pada hari ke-3 secara signifikan tetapi jumlah pembuluh darah tidak berbeda secara bermakna.
A 3-Years Pneumonia Incidence in Burn Cases with Inhalation Injury at the Burn Center of Dr. Soetomo General Hospital Surabaya in 2015-2018 Salsabilla Gina Rania; Lynda Hariani; Helmia Hasan; Iswinarno Doso Saputro
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 1 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I12022.27-30

Abstract

Introduction: Inhalation injury is one of burns impact. Airway burns due to inhalation injury is a non-specific term which refer to all respiratory tract injuries occurred due to irritative chemicals, including heat and smoke during inspiration. Inhalation injury increases the risk of death in burns. Pneumonia is one of burns-related inhalation injury complications.Methods: This was a descriptive retrospective study aiming to determine the incidence of pneumonia in burn patients with inhalation injury using secondary data at Burn Center Dr. Soetomo General Hospital Surabaya in the period of January 2015 - December 2018.Results: There were 5 cases of pneumonia in 14 burn cases with inhalation injury (35.71%). Respectively, 2 and 3 cases were found in 2017 and 2018. There were 2 female (40%) and 3 male (60%) patients, with age varied within 28-73 years old. The burn area of burn patients with inhalation injury and pneumonia were found by 15%, 20%, 24%, 32% and 71%, or within the classification of 11-20% burn area, and most complication found was hypoalbuminemia, as much as 3 cases (60%).\Conclusion: Most pneumonia in burn cases with inhalation injury was occurred in 2018, dominated by male patients. The age of the patient were ranging from early adulthood to elderly. Most burns were in the range of 11-20% burn area with the most complication found was hypoalbuminemia.
Efek Probiotik Terhadap Interleukin-6 Serum dan Skor Depresi pada Pasien Luka Bakar Nur Aida; Azimatul Karimah; Iswinarno Doso Saputro
Jurnal Psikiatri Surabaya Vol. 6 No. 2 (2017): Desember
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1440.63 KB) | DOI: 10.20473/jps.v6i2.19433

Abstract

Latar Belakang: Luka bakarmerupakan respon lokal suatu jaringan dengan atau tanpa respon sistemik terhadap suatu perpindahan energi dari sumber fisik atau kimia. Perawatan luka bakar memerlukan waktu yang lama. Dampak pada individu karena luka bakar dirasakan sejak awal cedera dan meluas di seluruh kehidupan seseorang. Pada luka bakar tejadi pelepasan mediator inflamasi khususnya interleukin-6 dan terganggunya berbagai faal tubuh, salah satunya homeostasis mikrobiota usus. Komorbiditas psikiatrik yang terjadi berkisar 45,5 %, dimana depresi yang hadir akan memperberat kondisi pasien. Probiotik dapat menurunkan kadar interleukin-6 dan mencegah gejala depresi secara langsung maupun tidak langsung. Studi ini untuk menilai efek suplementasi probiotik pada gejala depresi, parameter menggunakan biomarker IL-6 serum.Tujuan: Membuktikan efek probiotik terhadap interleukin-6 serum dan skor depresi pada pasien luka bakar.Metode: Desain penelitian adalah non randomized control trial. Sampel diambil dengan consequtive sampling. Pemberian probiotik pada hari ke 4 sampai hari ke 19 perawatan, kadar interleukin-6 serum diukur pada hari ke-4 (sebelum pemberian probiotik) dan hari ke 19 (setelah pemberian probiotik) dengan ELISA. Kelompok kontrol tidak menerima probiotik. Kriteria depresi diukur dengan Hamilton Depression Rating Scale (HDRS). Kedua alat ukur tersebut telah melalui uji validitas dan reliabilitasnya dari penelitian sebelumnya dan HDRS telah diadaptasi ke dalam bahasa Indonesia. Analisis data menggunakan uji komparatif.Hasil: Hasil uji statistik menunjukkan tidak ada perbedaan yang bermakna antara kelompok perlakuan dan kontrol.Kesimpulan: Pemberian probiotik tidak berpengaruh terhadap kadar interleukin-6 serum dan derajat depresi dibandingkan kontrol.
Dosis Efektif Enoxaparin dalam Mencegah Terjadinya Trombosis pada Anastomosis Arteri Femoralis Tikus I Made Suka Adnyana; Iswinarno Doso Saputro
JBN (Jurnal Bedah Nasional) Vol 1 No 2 (2017): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.71 KB) | DOI: 10.24843/JBN.2017.v01.i02.p01

Abstract

Tujuan: untuk mengetahui dosis efektif enoxaparin dalam mencegah terjadinya trombosis pada anastomosis mikrovaskular. Metode: penelitian ini bersifat eksperimental dengan rancangan the randomized post test only control group design. Terdapat 33 tikus jantan Rattus norvegicus Wistar strain yang dikelompokkan menjadi tiga perlakuan yaitu perlakuan A (enoxaparin 0,75 mg/kg), B (enoxaparin 1 mg/kg), dan C (kontrol). Tuck model anastomosis dilakukan pada arteri femoralis, kemudian luas trombus yang terjadi pada pembuluh darah dibandingkan dengan diameter lumen pembuluh darah diukur dengan graticule lens dan dinyatakan dalam persen. Hasil: trombus terbentuk pada semua subyek penelitian baik pada kelompok perlakuan maupun kontrol. Rerata persentase luas trombus pada kelompok enoxaparin 0,75 mg/kg adalah 24,3%, enoxaparin 1 mg/kg sebesar 19,8% dan kelompok NaCl 0,9% sebesar 79,4%. Terdapat perbedaan antara perlakuan pemberian enoxaparin dosis 0,75 mg/kg dan 1 mg/kg dengan kontrol, namun tidak ada perbedaan bermakna rerata persentase luas trombus diantara kelompok enoxaparin dosis 0,75 mg/kg dan dosis 1 mg/kg (p=0,624). Perlu dilakukan penelitian secara klinis guna melihat efektivitas enoxaparin dalam meningkatkan patensi anastomosis pada free flap maupun replantasi. Simpulan: pemberian enoxaparin dosis 0,75 mg/kg dan enoxaparin dosis 1 mg/kg secara subkutan efektif mengurangi persentase luas trombus pada anastomosis arteri femoralis tikus. Tidak terdapat perbedaan efektivitas yang bermakna dalam mengurangi persentase luas trombus pada anastomosis arteri femoralis tikus setelah diberikan dosis enoxaparin 0,75 mg/kg dan 1 mg/kg secara subkutan.
EVALUASI PENGGUNAAN ANTIBIOTIK PROFILAKSIS UNTUK TINDAKAN SURGICAL DEBRIDEMENT PADA LUKA BAKAR ANAK MENGGUNAKAN METODE ATC/DDD : EVALUATION OF PROPHYLAXIC ANTIBIOTICS FOR SURGICAL DEBRIDEMENT IN CHILDREN WITH BURN INJURY USING ATC/DDD METHOD Oki Nugraha Putra; Iswinarno Doso Saputro; Vaniode Dyahayu Vitari; Ardia Respati Hapsari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.357

Abstract

Pasien luka bakar berisiko tinggi terjadi infeksi. Salah satu cara untuk menurunkan risiko infeksi pada pasien luka bakar adalah surgical debridement yang bertujuan untuk menghilangkan jaringan kulit yang mengalami nekrosis. Tindakan surgical debridement memiliki risiko kontaminasi bakteri yang dapat meningkatkan infeksi luka operasi. Pemberian antibiotik profilaksis diperlukan untuk mencegah infeksi pada surgical debridement. Tujuan penelitian ini ialah untuk mengevaluasi kuantitas penggunaan antibiotik profilaksis untuk tindakan surgical debridement pada pasien luka bakar anak menggunakan metode Anatomical Therapeutic Chemical/Define Daily Dose (ATC/DDD). Penelitian ini merupakan penelitian retrospektif menggunakan rekam medis pasien luka bakar anak yang dirawat di RSUD Dr. Soetomo pada tahun 2018-2020. Hasil penelitian ini didapatkan 30 pasien luka bakar anak yang memenuhi kriteria inklusi. Antibiotik profilaksis secara keseluruhan diberikan secara intravena dengan pemakaian terbanyak yaitu sefazolin (35%), seftazidim (32%), dan amikasin (8%). Hasil evaluasi menggunakan ATC/DDD didapatkan total nilai DDD/operation-days ialah 2,65 DDD/operation-days yang mengindikasikan 2,65% pasien menerima DDD antibiotik profilaksis per hari untuk tindakan surgical debridement. Antibiotik profilaksis yang masuk dalam segmen DU 90% antara lain sefazolin 0,87 DDD/operation-days, seftazidim 0,49 DDD/operation-days, seftriakson 0,43 DDD/operation-days, dan amikasin 0,41 DDD/operation-days. Selain itu, berdasarkan ketepatan pemilihan jenis antibiotik profilaksis diperoleh persentase sebesar 60%. Kesimpulan pada penelitian ini ialah ditemukan perbedaan jenis antibiotik profilaksis yang digunakan untuk tindakan surgical debridement dengan yang tercantum di pedoman serta terdapat hubungan antara luas luka bakar dengan lama perawatan di rumah sakit serta frekuensi surgical debridement. Berdasarkan ATC/DDD, RSUD Dr.Soetomo telah cukup selektif dalam memilih antibiotik profilaksis untuk tindakan surgical debridement pada pasien luka bakar anak.
DEVIATION AND ATROPHY OF MIDDLE PHALANX OF HAND FOLLOWING PARTIAL SEPARATION IN SYNDACTYLY PATIENT: THEIR FAULT OR OURS? Kusuma, Diana Murtiati; Saputro, Iswinarno Doso; Rizaliyana, Sitti; Beta Subakti Nata’atmadja
Jurnal Rekonstruksi dan Estetik Vol. 3 No. 1 (2018): Jurnal Rekonstruksi dan Estetik, June 2018
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1054.23 KB) | DOI: 10.20473/jre.v3i1.24366

Abstract

Highlights: Complex syndactyly reconstruction presents surgical challenges, often resulting in rotational, angular, and nail deformities post-surgery. The early correction of congenital syndactyly, combined with dorsal rectangular flap usage and full-thickness skin grafts, leads to satisfactory outcomes and reduces the need for multiple surgeries per web Abstract: Introduction: Syndactyly is failure of differentiation in which the fingers fail to separate into individual appendages. It is the most common congenital hand anomaly, with an incidence of 1 in 2,000 to 2,500 live births. Surgical separa­tion of fingers as early as 6 month-old is indicated when syndactyly involves digits of unequal length (i.e., ring and little fingers). Early separation is also required in complex syndactyly and cases of acrosyndactyly. The timing of sur­gery of all other cases of syndactyly remains somewhat controversial; most suggest surgical correction before age of 18 months, whereas others prefer to wait until after this age. Case Illustration: A 13-year old boy, presented with fusion of all fingers of the right hand at birth. Prior to his current visit, he underwent partial separation of the right fingers at the age of 6 y.o. at a local hospital. Following partial separation, the fingers did not grow normally. Cur­rent X-ray showed atrophy and deviation of middle phalanx. We performed separation of syndactyly between index and middle finger, and between fourth and small finger in our hospital. Interdigital webbings are released using local flap and the remaining raw surface is covered using full-thickness skin grafts. On follow up, the patient showed good functional and aesthetic outcome. He is able to write with his right hand with better coordination. Discussion: Complex syndactyly reconstruction is a challenging surgical problem. Common post surgical findings include rotational deformity, angular deformity, and nail deformity. We describe how we have altered our approach in these findings. Conclusion: Congenital syndactyly should be corrected early in life. Careful dissection, the use of a dorsal rectangular flap in combination with 2 volar triangular flaps, and use of full thickness skin grafts ensure a satisfactory outcome and minimize the number of operations per web.
Co-Authors Agus Santoso Budi, Agus Santoso Amandita, Tiara Amatullah, Nida' Fahima Ardia Respati Hapsari Aruja Dhar Aryati Asmaradianti, Aryunidya Azzahra, Alya Mutiara Diah Mira Indramaya Dwi Murtiastutik Evy Evrianti Fabian, Pascalis Hamiseno, Gifta Marshanda Qanitah Hariani, Lynda Hasan, Helmia Hesty Aulia Palupi Hutagalung, Magda Rosalina Huvi, Indira I Made Suka Adnyana Irsyan Baginda Maulana Karimah, Azimatul Kurniawan, Rifqi Kusuma, Diana Murtiati Lilihata, Jilvientasia Godive Medisa Primasari Milan Muhammed Muhaimin Rifa’i N, Priscilla Valentin Nata’atmadja, Beta Subakti Ningrum, Laras Puspita Noverta, Dhitta Aliefia Nur Aida Nurfaiza, Diandra Yasmin Oki Nugraha Putra Perdanakusuma, Arda Rahmanisa Perdanakusuma, David Sontani Prasetyo, Arif Tri Putri, Nadia Tamara Rahel Yuana Sadikim Revita Widya Prasanti Rifqi Kurniawan Rizaliyana, Sitti Saleh Ashafi Salsabilla Gina Rania Samiyah Septin Mauludiyana Setya, Aldy Mulia Hati Sindhu, Florencia Christina Sintaningrum, Elisabeth Prajanti U H, Muhammad Aulia Vaniode Dyahayu Vitari Wahdini, Siti Isya Waode Fifin Ervina Wardhani, Rr. Indrayuni Lukitra Widjaja, Febe Alodia Willy Sandhika Wiwik Misaco Yuniarti Yoes Prijatna Dachlan Zakanito, Marelno Zarasade, Lobredia