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All Journal Jurnal Locus Penelitian dan Pengabdian Folia Medica Indonesiana
Bintan, Rio Tasti Surpa Rahmat
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Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Health Professions Mathematics Medicine & Pharmacology Neuroscience

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Hubungan HBA1C dan Pulsatility Index pada Penderita Stroke Trombotik Akut di RSUD Dr Soetomo Bintan, Rio Tasti Surpa Rahmat; Adrianto, Yudhi; Setyowati, Sita
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 11 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i11.5032

Abstract

Stroke merupakan penyebab utama disabilitas dan kematian nomor dua di dunia, dengan sebagian besar kasus berupa stroke iskemik. Diabetes mellitus menjadi salah satu faktor risiko penting karena hiperglikemia kronis dapat meningkatkan viskositas darah dan resistensi pembuluh serebral. Kadar HbA1c mencerminkan kontrol glikemik jangka panjang, sedangkan nilai pulsatility index (PI) dari pemeriksaan transcranial Doppler (TCD) menggambarkan resistensi vaskular otak. Penelitian ini bertujuan untuk menganalisis hubungan antara kadar HbA1c dan PI pada penderita stroke trombotik akut. Penelitian ini menggunakan desain observasional dengan pendekatan cross-sectional pada pasien stroke trombotik akut yang dirawat di bangsal saraf RSUD Dr. Soetomo Surabaya periode Oktober 2019–April 2020. Data diperoleh dari rekam medis pasien yang memenuhi kriteria inklusi (usia >18 tahun dan telah menjalani pemeriksaan TCD) serta eksklusi (stroke emboli). Analisis data menggunakan uji korelasi Spearman untuk variabel numerik dan uji Chi-square untuk variabel kategorik dengan tingkat signifikansi p<0,05. Sebanyak 32 subjek memenuhi kriteria, terdiri dari 24 laki-laki (75%) dan 8 perempuan (25%) dengan rata-rata usia 56,41 ± 13,22 tahun. Nilai rata-rata HbA1c adalah 6,55 ± 1,9%. Sebanyak 14 pasien (43,75%) memiliki PI Middle Cerebral Artery (MCA) tidak normal (rata-rata 1,8 ± 0,97) dan 18 pasien (56,25%) memiliki PI normal (rata-rata 0,87 ± 0,15). Analisis statistik menunjukkan tidak terdapat hubungan signifikan antara kadar HbA1c dan PI MCA (r=0,07; p=0,73).Secara klinis, temuan ini menunjukkan bahwa kontrol glikemik pada pasien stroke trombotik akut tidak berhubungan langsung dengan resistensi vaskular serebral, sehingga faktor lain kemungkinan berperan dalam perubahan hemodinamik otak.
HbA1c and Pulsatility Index in Middle Cerebral Artery of Patients with Acute Thrombotic Stroke Bintan, Rio Tasti Surpa Rahmat; Setyowati, Sita; Adrianto, Yudhi
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: 1. The findings of this study indicate that clinicians should remain vigilant, as effective glycemic control, reflected by optimal HbA1c levels, does not necessarily correlate with favorable distal cerebrovascular resistance, as measured by pulsatility index (PI). 2. This study recommends that patients with acute thrombotic stroke undergo a comprehensive examination to ensure an accurate diagnosis and appropriate treatment. Abstract Stroke is the second leading cause of death and disability in the world. Diabetes mellitus is a risk factor for stroke with an increase in blood viscosity associated with hyperglycemia, and HbA1c is a well-established biomarker primarily used for the long-term monitoring of glycemic control in patients with diabetes mellitus. The Pulsatility index (PI) parameter of Trans Cranial Doppler (TCD) can measure blood vessel resistance. This study was to prove the correlation between HbA1c and PI in Middle Cerebral Artery (MCA) of acute thrombotic stroke patients. A cross-sectional study was conducted to thrombotic stroke patients treated at the neurological ward of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia from March 2019 to April 2020 who met the inclusion and exclusion criteria. Data were obtained from medical records. Statistical analysis was performed using Spearman test for numerical data and Chi-square for categorical data with a significant value of p <0.05. There were 32 subjects who met the inclusion and exclusion criteria. A total of 24 subjects (75%) were males and 8 (25%) females with a mean age of 56.41±13.22 years. PI MCA results were abnormal in 14 subjects (43.75%) with an average of 1.8±0.97 and PI MCA was normal in 18 subjects (56.25%) with an average of 0.87±0.15. The average HbA1c was 6.55±1.9%. There was no statistically significant association observed between HbA1c and PI in MCA examination (r=0.07; p=0.73). In conclusion, the findings of this study indicate the lack of correlation between pulsatility index and HbA1c in patients with acute ischemic stroke. This underscores the importance of comprehensive cerebrovascular evaluation regardless of HbA1c status.
Co-Authors Adrianto, Yudhi Setyowati, Sita