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All Journal Jurnal EduHealth Paradigma: Jurnal Filsafat, Sains, Teknologi, dan Sosial Budaya
Runggu Retno Justiani Napitupulu
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Humanities Computer Science & IT Education Health Professions Languange, Linguistic, Communication & Media Public Health Social Sciences Veterinary

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The Efficacy of Soursop Leaf Extract as a Hepatoprotector in White Rats Rattus norvegicus Induced by the Antituberculosis Drugs Isoniazid and Pyrazinamide Runggu Retno Justiani Napitupulu; Jenny Ria Sihombing; Bernika Ayu Frastika; Greace Ari Sulastry Aritonang
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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Abstract

The use of antituberculosis drugs isoniazid and pyrazinamide triggers hepatotoxicity. Soursop leaves have a hepatoprotective effect because they contain antioxidant compounds that can help inhibit and prevent oxidative damage to the liver. This study aims to determine the effect of soursop leaf extract on the histopathological appearance of rat liver induced by isoniazid and pyrazinamide. This research is a laboratory experimental research using design posttest only control group design. This study used 24 rats Wistar divided into four groups and given treatment for 14 days. The negative control group was not given soursop leaf extract. The positive control group was given isoniazid and pyrazinamide, the treatment group I was given isoniazid and pyrazinamide and 1 hour later continued with soursop leaf extract 72 mg/day giving soursop leaf extract 144 mg/day. The dose of isoniazid used was 189 mg/day, while the dose of pyrazinamide was 252 mg/day. Termination of rats was carried out on the 15th day to collect rat liver organs. Furthermore, histopathological examination of the rat liver was carried out. The results showed that the rats in the negative control group had normal histopathological features. In the positive control group, there was a picture of hydropic degeneration. The histopathological picture of the rat liver in the treatment group 1 showed a picture of parenchymatous degeneration and in the treatment group 2, the liver cells were normal. Administration of soursop leaf extract affected the histopathological picture of rat liver induced by isoniazid and pyrazinamide.
Uji Aktivitas Anti Jamur Ekstrak Etanol Daun Pepaya Jepang (Cnidoscolus Aconitifolius) terhadap Pertumbuhan Malassezia Furfur Mhd Alhafiz Siddiq Nasution; Susi Sembiring; Runggu Retno Justiani Napitupulu
Paradigma: Jurnal Filsafat, Sains, Teknologi, dan Sosial Budaya Vol. 32 No. 1 (2026): Paradigma: Jurnal Filsafat, Sains, Teknologi, dan Sosial Budaya
Publisher : Universitas Insan Budi Utomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33503/paradigma.v32i1.3423

Abstract

Malassezia furfur is an opportunistic fungus associated with various skin disorders, including pityriasis versicolor and seborrheic dermatitis. Long-term use of synthetic antifungal agents may lead to side effects and drug resistance, highlighting the need for alternative treatments derived from natural sources. Japanese papaya leaves (Cnidoscolus aconitifolius) contain bioactive compounds such as flavonoids, alkaloids, and saponins, which are known to exhibit potential antifungal properties. This study aimed to evaluate the antifungal activity of the ethanol extract of Japanese papaya leaves against the growth of Malassezia furfur in vitro. This research employed a true experimental design using the diffusion method to measure inhibition zone diameters at concentrations of 25%, 50%, and 75%. Ketoconazole was used as a positive control, while the solvent served as a negative control. The results showed that the 75% concentration exhibited strong inhibitory activity with a mean inhibition zone of 10.82 mm, whereas the 25% and 50% concentrations demonstrated weak inhibitory effects. Although the extract showed lower activity compared to ketoconazole, it was significantly more effective than the negative control. In conclusion, the ethanol extract of Japanese papaya leaves has potential as a natural antifungal agent against Malassezia furfur, although its effectiveness remains lower than that of synthetic antifungal drugs.
Co-Authors Bernika Ayu Frastika Greace Ari Sulastry Aritonang Jenny Ria Sihombing Mhd Alhafiz Siddiq Nasution Susi Sembiring