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All Journal Damianus Journal of Medicine Jurnal Respirasi (JR)
Husna, Annisa Nurul
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Health Professions Medicine & Pharmacology Public Health

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A Paralisis Periodik Hipokalemia Dengan Renal Tubular Asidosis Tipe Distal: Laporan Kasus Husna, Annisa Nurul; Mahestari, Anisa Novia; Puspitasari, Gita; Khafiya, Nida'an
Bahasa Indonesia Vol 24 No 2 (2025): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v24i2.4886

Abstract

Pendahuluan: Paralisis periodik hipokalemia merupakan episode kelemahan otot berat yang jarang terjadi dengan prevalensi 1:100.000. Renal tubular asidosis terjadi saat ginjal tidak mampu menjaga homeostasis normal asam-basa karena defek tubular dalam ekskresi asam atau reabsorbsi ion bikarbonat. Kasus: Seorang laki-laki berusia 18 tahun mengeluhkan kelemahan anggota gerak dan leher sejak bangun tidur di pagi hari. Keluhan diawali muntah lebih dari 5 kali sejak 1 hari yang lalu. Keluhan disertai batuk dan sesak sesekali sejak 1 minggu terakhir. Pemeriksaan kekuatan motorik ekstremitas atas 4444/4444 dan ekstremitas bawah 4444/3333. Pemeriksaan elektrolit menunjukkan kalium serum 1,7 mmol/L dan klorida 110 mmol/L. Analisis gas darah menunjukkan pH 7,3, pCO2 24,4 mmHg, dan HCO3- 13 mmol/L. Analisis urin menunjukkan pH urin 8,0, kalium urin 231 mmol/24 jam, klorida urin 260 mmol/24 jam, dan kreatinin urin sebesar 15,4 mmol/24 jam. Rasio kalium banding kreatinin urin adalah 15. Pasien didiagnosis sebagai paralisis periodik hipokalemia dengan renal tubular asidosis tipe distal. Pasien mendapatkan terapi KCl intravena dan KCl per oral selama 2 hari dan didapatkan perbaikan. Simpulan: Paralisis periodik hipokalemia merupakan penyakit kelemahan tubuh yang dapat disebabkan renal tubular asidosis. Diagnosis renal tubular asidosis tipe distal ditegakkan berdasarkan adanya asidosis metabolik hiperkloremia, hipokalemia berat, anion gap urin positif, dan fungsi ginjal normal. Koreksi kalium diberikan untuk memperbaiki keadaan pasien. Prognosis umumnya baik setelah koreksi kalium.
Digital Technology in Improving Tuberculosis Treatment Adherence: A Systematic Review Jasmine, Amirah; Husna, Annisa Nurul; Kamal, Safira
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.82-90

Abstract

Introduction: Indonesia ranks second globally in the number of tuberculosis (TB) cases. One strategy to eliminate TB is to use research and technology. The long duration of treatment may lead to non-adherence. Digital health interventions have become a promising option for monitoring treatment adherence. This review aimed to evaluate how digital technology interventions can improve treatment adherence in TB. Methods: A systematic review was conducted by identifying primary data articles published on online platforms by using specific keywords. The sample size was determined in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All data were then systematically assessed and reviewed. Results: Of the 14 included studies, 13 found that digital technology led to high adherence to TB medication, while 1 found no link between usability and medication adherence. The intervention arm reached 99 % (pill dispenser) in adherence, and the lowest was 71.1 % (video-observed therapy). Conclusion: Digital technology intervention still has some obstacles despite promising outcomes. The limitations are poor internet connectivity, mobile phone ownership, and inferior-quality phones. This review could not assess the degree of adherence alteration, as the included studies showed adherence only at the end of the study. In addition, 4 of the 14 studies were categorized as having some concerns based on the risk of bias tool. Further studies are needed to assess how digital technology influences adherence to TB medication.
Co-Authors Jasmine, Amirah Kamal, Safira Khafiya, Nida'an Mahestari, Anisa Novia Puspitasari, Gita