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All Journal Jurnal Kesehatan Medika Saintika Jurnal Katalisator
Endang Suriani
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Agriculture, Biological Sciences & Forestry Chemistry Health Professions Medicine & Pharmacology Nursing Public Health Other

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RELATIONSHIP BETWEEN ANTIPSYCHOTIC THERAPY WITH CREATININE LEVELS IN SCHIZOPHRENIA PATIENTS Marisa, Marisa; Endang Suriani; Rinda Lestari; Lisa Fradisa
JURNAL KATALISATOR Vol. 10 No. 1 (2025): Jurnal Katalisator ( On Progres)
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i1.3427

Abstract

Schizophrenia is a condition of severe mental disorder, characterized by many disturbances in thinking, language, perception and sense of awareness. The use of antipsychotic therapy in the long term can cause damage to kidney function and aggravate the work of the kidneys marked by increased creatinine levels. The purpose of this study was to determine the relationship between duration of antipsychotic therapy and creatinine levels in schizophrenic patients at the Mendawai Health Center. The type of research used is analytic research with a cross sectional approach. In this study the sampling technique used was purposive sampling. This study used the T-Independent Sample T Test. The results showed that there was a relationship between duration of antipsychotic therapy and creatinine levels in schizophrenic patients. It can be seen that the average value of respondents in the category of long antipsychotic therapy is 1.06 and short antipsychotic therapy is 0.71 and the value of equal variance assumed has a sig (2 Talled) p-value of 0.005 (<0.05), so Ha is accepted. So in conclusion there is a significant relationship between the duration of antipsychotic therapy and creatinine levels in schizophrenic patients at the Mendawai Health Center. It is recommended to pay more attention to the side effects of the treatment carried out for further therapy.
UJI PERBANDINGAN EFEKTIFITAS REBUSAN DAUN KEMANGI (Oncimum Basilicum) DAN DAUN SIRSAK (Annona Muricata L) TERHADAP KEMATIAN LARVA NYAMUK AEDES AEGYPTI Vetra Susanto; Endang Suriani; Dian Dilastri Putri
Jurnal Kesehatan Medika Saintika Vol 17, No 1 (2026): Juni 2026
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v17i1.30971

Abstract

Dengue Hemorrhagic Fever (DHF) is still a health problem in Indonesia and is transmitted through the bite of the Aedes aegypti mosquito. Continuous use of chemical larvicides can cause resistance and environmental pollution, so alternatives to natural larvicides are needed, such as basil leaves (Ocimum basilicum) and soursop leaves (Annona muricata L.). This study aims to compare the effectiveness of boiled basil and soursop leaves on the death of third instar Aedes aegypti larvae. The research used a laboratory experimental method with a completely randomized design (CRD). The concentrations used were 25%, 30%, 35% and 40% with three repetitions and observations for 24 hours. Data analysis was carried out using normality, homogeneity, One Way ANOVA, Duncan test, and probit tests to determine LC50. The results showed that the percentage of larval death in boiled basil leaves was 23.3%; 36.6%; 40%; and 60%, while soursop leaf decoction is 70%; 76.6%; 76.6%; and 86.6%. One Way ANOVA test showed that there were significant differences between treatments (p < 0.05). Decoction of soursop leaves is more effective than decoction of basil leaves as a natural larvicide against Aedes aegypti larvae.
Co-Authors Dian Dilastri Putri Fradisa, Lisa Marisa Marisa Rinda Lestari Vetra Susanto