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Antidiabetic Activity of Ethanol Extract of Red Castor Roots (Jatropha gossypiifolia L.) in White Wistar Rats Induced by Alloxan Putri, Annisa Nur Lathifah Amanda; Haryoto, Haryoto
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23467

Abstract

Diabetes mellitus is a metabolic disorder indicated by high blood glucose levels. Red castor is a plant that has potential in the treatment of diabetes mellitus. This study aims to measure the impact of ethanol extract from the roots of the red castor plant (Jatropha gossypiifolia L.) in reducing blood glucose levels in male white Wistar rats that have been induced with alloxan at a dose of 150 mg/kgBW. The study used 25 male mice divided into 5 treatment groups. The negative control group was given distilled water as a substitute for the substance being tested, while the positive control group was given a dose of glibenclamide of 5 mg/kgBW. Apart from that, there were 3 treatment groups that were given extract from red castor root at doses of 25, 50 and 100 mg/kgBW respectively. Treatment was given for 14 days. Alloxan 150 mg/kgBW was used so that mice experienced an increase in blood glucose levels exceeding 200 mg/dL. The results of decreasing blood glucose levels respectively at doses of 25, 50, and 100 mg/kgBW were 101.0 mg/dL, 81.6 mg/dL, and 79.4 mg/dL. The percentage reduction in blood glucose levels obtained at doses of 25, 50, and 100 mg/kgBB was 73.63%, 77.89%, and 80.10%. Based on the results of statistical tests, the effect of using ethanol extract of red castor root at doses of 25 mg/kgBB, 50 mg/kgBB, and 100 mg/kgBB is comparable to using 5 mg/kgBB glibenclamide
Edukasi Kesehatan Kognitif dan Senam Otak Lansia Menuju Lansia Mandiri dan Bahagia pada Ibu-Ibu Penggerak PKK Desa Mliwis, Boyolali, Jawa Tengah Rahmawati, Juwita; Yulianti, Tri; Putri, Annisa Nur Lathifah Amanda; Windarti, Septiana; Fadhilah, Arini Fadhilah; Wahyuni, Arifah Sri; Sukmawati, Anita; Indrayudha, Peni; Setyadi, Gunawan; Wulandari, Febri; Imanto, Teguh; Santhyami, Santhyami
Abdi Geomedisains Vol. 6, No. 2, December 2025
Publisher : Universitas Muhammadiyah Surakarta

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Abstract

A prevalent issue among the elderly is cognitive deterioration. Modifications in behavior and the adoption of a healthy lifestyle have been demonstrated to mitigate cognitive decline in the elderly. The objective of community service initiatives is to disseminate knowledge regarding cognitive health in the elderly and to offer brain workouts to the community, particularly targeting women who are PKK activists in Mliwis Village. This community service initiative employs an instructional methodology that incorporates PowerPoint presentations and leaflets, utilizing a one-group pre-test and post-test design. The event took place at the Posyandu Sidorejo in Mliwis Village, Boyolali. The target audience for this activity was PKK mothers in Mliwis Village, Boyolali Regency, Central Java. To measure the level of knowledge about cognitive health, a questionnaire developed by the community service team was used. This activity consisted of six stages, namely opening, pretest, education, group brain exercises, discussion, and post-test. 51 participants, comprising PKK mothers, attended this activity. The most extensive age range was 31-40 years old, with 16 (31.4%) participants, and the largest occupation was housewife, with 36 (70.6%) participants. The education and discussion activities went well. The enthusiasm of the participants also increased with the joint brain exercises. The average pretest and posttest scores were 90.26 ± 10.78 and 93.68 ± 7.50, respectively. There was a significant difference in knowledge between the pretest and post-test measurements (p = 0.034; < 0.05). It is hoped that this educational activity will help form independent and happy elderly people.