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All Journal Jurnal Dedikasi Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Martabe : Jurnal Pengabdian Kepada Masyarakat JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat)
Lilik Yusetyani
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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EVALUATION OF SST-2 ROLE IN LVH REGRESSION OBTAINED IN HYPERTENSIVE MICE MODELS AFTER BLOCKING RENIN-ANGIOTENSIN SYSTEM Yusetyani, Lilik; Rofida, Siti; Lestari, Dian Yuliartha; Kurniawan, Wawan; Hijriani, Nursela; Saputra, Ilham Niawan; Soeharto, Setyawati; Rahman, Mohammad Saifur
Journal of Tropical Life Science Vol 9, No 1 (2019)
Publisher : Journal of Tropical Life Science

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Abstract

Soluble ST2, is a protein which acts as a decoy receptor for interleukin-33, and served as biomarker associated with left ventricular hypertrophy (LVH).  Few data exist in evaluating the effects of anti-hypertensive agents on the role-played form ST2 on regression of LVH. This study was designed to compare the effects of captopril and valsartan on blood pressures, plasma renin and soluble ST2 levels and regression of LVH in hypertensive mice models. Twenty-four male mice (Mus musculus L), were divided into four groups, namely aquadest/control, L-NAME, L-NAME + captopril and L-NAME + valsartan groups respectively. Mice blood pressures were measured on day 14th after induction with L-NAME extract 1.75 mg/25 g BW/day (pretreatment) and day 14th post treatment. Levels of plasma renin, sST2, and ventricular wall thicknesses reflecting LVHs, were measured on day 14th post treatment. Administration of L-NAME within 14 days resulted in making mice models to be hypertensive paralleled by an increase of Ventricular wall thickness. Treatment with captopril and valsartan lowered the blood pressures to normal level within the next 14 days. Valsartan and captopril treatment induced a significant decrease of plasma renin level. Valsartan, but not for captopril treatment prevented wall thickness increase (p < 0.05), while plasma sST2 was not able to mirroring this effect. Captopril and valsartan had similar effect in lowering plasma renin level and   blood pressure, but sST2 seems to be not involved in LVH regression obtained in hypertensive mice models after blocking renin-angiotensin system.
Co-Authors Aghnia Fuadatul Inayah Ahmad Shobrun Jamil Ahyana Fitrian, S.Farm. Apt Ahyana Fitrian, S.Farm. Apt, Ahyana Fitrian, Arum Puspitasari, Alvina Brilian Yustika Deti Cahya Wulandari, Wahyu Dian Yuliartha Lestari Didik Hasmono Dra. Uswatun Chasanah, Apt. Dra. Uswatun Chasanah, Apt., Dra. Uswatun Drs. Ahmad Inoni, Apt Drs. Ahmad Inoni, Apt, Drs. Ahmad Dwi Cahyo, Fatih Elva Asmiati Fuadatul Inayah, Aghnia Hidayatullah, Wildan Indra Maulana, Muhammad Muktamiroh Muktamiroh Nadriatul Utami Nadriatul Utami Rahman, Mohammad Saifur Reva Rahmawati, Annisa Saputra, Ilham Niawan Setyawati Soeharto, Setyawati Siti Rofida Utami, Nadriatul Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono