Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Medula Jurnal Ilmu Kedokteran dan Kesehatan
Akbar, Muhammad Zakky Putra
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Efektivitas Pemberian Ekstrak Buah Adas (Foeniculum vulgare) Terhadap Pertumbuhan Bakteri Helicobacter pylori Akbar, Muhammad Zakky Putra; Wijaya, Sofyan; Carolia, Novita; Sukohar, Asep
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 4 (2025): Volume 12 Nomor 4
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i4.18509

Abstract

Helicobacter pylori (H.pylori) merupakan penyebab utama berbagai gangguan lambung seperti gastritis kronis, ulkus, hingga kanker lambung pada beberapa kasus. Infeksi H.pylori, yang memiliki prevalensi tinggi dan semakin kebal terhadap antibiotik, telah menjadi masalah kesehatan global sehingga. Penelitian ini bertujuan mengkaji potensi antibakteri ekstrak etanol buah adas (Foeniculum Vulgare) terhadap bakteri Helicobacter pylori. Pengujian dilakukan menggunakan metode cakram antibakteri dengan variasi konsentrasi ekstrak: 5%, 10%, 20%, 40%, dan 80%. Hasil penelitian menunjukkan bahwa kemampuan hambat terhadap H.pylori meningkat sejalan dengan peningkatan konsentrasi ekstrak, di mana konsentrasi 80% menunjukkan zona hambat tertinggi dengan rata-rata diameter 5,37 mm. Aktivitas antibakteri ini diperkirakan terkait dengan kandungan flavonoid dan fenolik pada buah adas yang bersifat bakteriostatik dan bekerja dengan menghambat sintesis asam nukleat, merusak membran sel, serta mengganggu metabolisme energi bakteri. Kandungan antioksidan pada ekstrak ini juga berpotensi melindungi sel lambung dari kerusakan oksidatif. Temuan ini menunjukkan bahwa buah adas berpotensi sebagai alternatif agen antibakteri untuk mengatasi infeksi H.pylori, terutama di tengah meningkatnya resistensi terhadap antibiotik konvensional.
Pengaruh Ekstrak Buah Adas (Foeniculum vulgare) terhadap Pertumbuhan Bakteri Salmonella typhi Secara In Vitro Akbar, Muhammad Zakky Putra; Wijaya, Sofyan Musyabiq; Carolia, Novita; Sukohar, Asep
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1271

Abstract

Bacterial infections, especially those caused by Salmonella typhi, are a global health challenge, including in Indonesia, where there is a high prevalence of typhoid fever. Treatment of this infection generally relies on antibiotics, but increasing antibiotic resistance is becoming a big problem. Therefore, there is a need for alternative treatments that are safer and more effective. This study aims to evaluate the ability of ethanol extract of fennel fruit (Foeniculum vulgare) to inhibit the growth of Salmonella typhi. Extraction was carried out using the maceration method using 70% ethanol, followed by evaporation of the solvent to obtain a stock solution. The extract concentrations tested included 5%, 10%, 20%, 40%, and 80%, with distilled water as a negative control and antibiotics as a positive control. Antibacterial testing was carried out using the disk diffusion method on Mueller Hinton Agar media, and the inhibition zone was measured after 48 hours of incubation. The results showed that fennel fruit extract effectively inhibited the growth of Salmonella typhi at an extract concentration of 20%, with the diameter of the inhibition zone increasing as the concentration increased, reaching 4.75 mm at a concentration of 80%. Statistical tests with Kruskal-Wallis showed significant differences between treatments. This research proves that ethanol extract of fennel fruit has antibacterial potential which can be used as an alternative in treating Salmonella typhi infections, especially considering that it is safer than synthetic antibiotics.
Co-Authors Asep Sukohar Novita Carolia Sofyan Musyabiq Wijaya Wijaya, Sofyan