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Thantrira Porntaveetus
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Dentistry

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The Tooth Agenesis in Clinical Practice: A review of Case Reports Michael Dany; Ameta Primasari; Ervina Sofyanti; Sry Suryani Widjaja; Thantrira Porntaveetus
Dentika: Dental Journal Vol. 28 No. 1 (2025): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v28i1.20149

Abstract

Tooth agenesis (TA) relates to multiple congenital dental disorder and the most prevalent developmental disorders affecting approximately 200 million people globally. The management of TA require interdisciplinary dental approaches. Therefore, this study aimed to conduct a case report evaluation of TA based on population and ethnicity. This scoping reviews based on  Preferred Reporting Items for Systematic Reviews and Meta-Analyses, has been registered in Open Science Framework. Relevant articles were retrieved from Proquest, Science Direct, PubMed, and SpringerLink databases with keywords comprising of ‘Prevalence’ AND ‘Tooth Agenesis’ AND ‘Nonsyndromic or Syndromic’. From 2014 to 2024, there were only five non-syndromic tooth agenesis case reports were included to be reviewed. The review of multiple case reports of tooth agenesis demonstrated significant variability in clinical and radiography evaluation involving inheritance pattern. By early identification in mixed dentition, the comprehensive and individualized treatment approaches are required to address both esthetics and functional outcomes. Further population-based studies of genetic involvement in TA can contribute early detection of malocclusion.   
The Role of PAX9 and MSX1 Variants in Non-Syndromic Tooth Agenesis Finna; Ameta Primasari; Sry Suryani Widjaja; Thantrira Porntaveetus; Ervina Sofyanti
Dentika: Dental Journal Vol. 28 No. 2 (2025): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v28i2.20787

Abstract

Non-syndromic tooth agenesis (NSTA) is the congenital absence of teeth without systemic involvement. Genetic polymorphisms in PAX9 and MSX1 are implicated in tooth development, but results vary across populations. Therefore, this study aims to explore the role of PAX9 c.-1031G>A and MSX1 671 T>C polymorphisms with NSTA in individuals from Medan. A total of 13 NSTA patients and 26 control were genotyped using PCR-restriction fragment length polymorphism (PCR-RFLP). The results showed that the AA genotype of PAX9 was absent in NSTA cases but found in 26.92% of controls. The GG genotype was reported to be more common in 38.46% of cases, while the G allele was prevalent in 69.23%. These trends suggested a potential association, but it was not statistically significant. In this study, all patients carried the TT genotype for MSX1. These results show a possible role of PAX9 polymorphisms in NSTA susceptibility and support the need for further studies in larger populations.   Keywords: Non-Syndromic, Tooth Agenesis, PAX9, MSX1
Co-Authors Ameta Primasari Ervina Sofyanti Finna Michael Dany Widjaja, Sry Suryani