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All Journal Dentika Dental Journal Jurnal Kesehatan Andalas Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Biomedika dan Kesehatan Jurnal Keperawatan dan Fisioterapi (JKF) Jurnal Kesmas dan Gizi (JKG) IJOEP : International Journal of Ecophysiology SCRIPTA SCORE Scientific Medical Journal The International Journal of Tropical Veterinary and Biomedical Research
Widjaja, Sry Suryani
Department Of Biochemistry, Faculty Of Medical, Universitas Sumatera Utara, Medan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Pengaruh Vitamin D terhadap Indeks Apoptosis pada Penderita Kanker Payudara Melya Susanti; Sry Suryani Widjaja; Denny Rifsal Siregar
Jurnal Kesehatan Andalas Vol 7, No 2 (2018)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v7i2.799

Abstract

Kanker payudara merupakan penyakit yang paling sering pada pada wanita dan menjadi penyebab kematian terbanyak akibat kanker. Penyebab kanker payudara sangat multifaktorial salah satu yang masih menjadi kontroversi adalah karena defisiensi vitamin D. Peran vitamin D dalam tubuh sangat luas selain menjaga homeostasis kalsium dan fosfat, vitamin D juga berperan sebagai anti kanker melalui mekanisme antara lain, menginduksi apoptosis. Peran vitamin D dalam menginduksi apoptosis pada sel kanker menarik perhatian, karena nilai apoptosis pada sel kanker dapat menjadi indikator untuk memprediksi respon sel kanker terhadap terapi. Tingkat apoptosis dinilai dengan indeks apoptosis. Tujuan penelitian ini adalah melihat pengaruh vitamin D terhadap indeks apoptosis pada kanker payudara. Sampel penelitian ini adalah penderita kanker payudara yang baru didiagnosis di Polibedah Onkologi RSUP HAM Medan. Pemeriksaan kadar vitamin D menggunakan metode ELISA dan Indeks apoptosis diperiksa dengan pewarnaan HE menggunakan mikroskop cahaya. Rerata indeks apoptosis pada penderita kanker payudara dengan kadar vitamin D yang sufisiensi lebih tinggi daripada rerata indeks apoptosis pada kadar vitamin D yang insufisiensi dan defisiensi. Simpulan hasil penelitian ini ialah terdapat perbedaan indeks apoptosis yang bermakna antara penderita kanker payudara dengan kadar vitamin yang sufisiensi dan dengan kadar vitamin D yang defisiensi. Rerata apoptosis indeks lebih tinggi pada kadar vitamin D yang sufisiensi.
The Activities of Antifertility Ethanol Extract Guava Leaves (Psidium Guajava L.) based on The Analysis Of Cement and Display of Immunohistochemistry Cyclooxygenase-2 In Testis Of Mice (Mus Musculus L.) RICA VERA BR TARIGAN; M. PANDAPOTAN NASUTION; SRY SURYANI WIDJAJA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (912.207 KB)

Abstract

Population growth increase, without support from good economic conditions, requirer population control. One of the program to control population growth is family planning program (KB). The participation of men in family planning programs is very important. Male contraception can utilize natural materials derived from plants. One of the herb is guava leaves (Psidium guajava L.) which contains many active substances that can inhibit the process of spermatogenesis. The purpose of this study was to determine the effect of ethanol extract guava leaves to the quality (concentration, viability, morphology, and motility) of spermatozoa and the expression of Cyclooxygenase-2 (COX-2) in the testes of mice (Mus musculus L.). The research used experimental design with completely randomized sampling method. Four treatment groups, namely P0 using aquadest as a control 0,5 mL, P1 using 15 mg/25g body weight extract orally, P2 using 20 mg/25g body weight extract orally, and P3 using 25 mg/25g body weight extract orally. Data were analyzed using One Way ANOVA followed by Bonferroni Post Hoc test 5%. The results showed that ethanol extract guava leaves with a dose of 15mg/25g body weight had significantly decreased sperm quality and increased expression of COX-2 in the testes of mice. This research indicates that guava leaves have a potential to be used as a herbal contraceptive.
The Role Of Serotonin In The Cognitive Function Of The Elderly : A Literature Review Rifqi Hamdani Pasaribu; Muhammad Ichwan; Aldy Safruddin Rambe; Ririe F. Malisie; Sry Suryani Widjaja
International Journal of Ecophysiology Vol. 5 No. 1 (2023): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v5i1.12313

Abstract

The last few decades have seen an increase in the number of elderly populations around the world. One consequence of an aging population is an increased incidence of impaired cognitive function. Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Alterations in serotonin (5-HT) function have been hypothesized to underlie a range of physiological, emotional, and cognitive changes in eldery. This paper provide reviews and references that a serotonin plays a role in the cognitive function of the elderly.
Cellular Senescence In White Adipose Tissue of Obese Mice Nova Eininta Sitepu; Sry Suryani Widjaja
International Journal of Ecophysiology Vol. 5 No. 1 (2023): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v5i1.12386

Abstract

Obesity is defined as excessive fat accumulation that presents as risk factor for various chronic diseases such as diabetes, cardiovascular disease, hypertension, hyperlipidemia, and cancer. The number of obese population has reached 1 trillion people worldwide and is expected to increase at 42% of the world population until 2030. Excess calories in obesity increase the formation of Reactive Oxygen Species (ROS) that cause DNA damage. DNA damage results in inhibition of the cell cycle and lead to cellular senescence. The mechanism of cell senescence caused by cell cycle inhibition can occur through the cellular senescence pathway by p53/p21 WAF1/CIP1 and p16INK4A / pRB. White adipose tissue is an appropriate reservoir to study of cellular senescence. White adipose tissue of obese model mice showed that there was cellular senescence with marked increase in p21 and p16 gene expression in obese mice
Direct PCR for Escherichia coli: a straightforward and cost-effective method Harahap, Desy Aryani; Yamamoto, Zulham; Widjaja, Sry Suryani; Mayasari, Evita
JURNAL KESMAS DAN GIZI (JKG) Vol. 7 No. 2 (2025): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jkg.v7i2.2606

Abstract

This study compares the direct PCR method with standard PCR to detect Escherichia coli. Escherichia coli is the most widely used organism in biology. Detection of E. coli in water and food is routinely performed, utilizing methods like PCR. The initial stage of PCR preparation involves DNA extraction, which requires a commercial kit. Consequently, this extraction process incurs additional expenses, time, and labor. Therefore, an alternative method is needed, such as direct PCR, which can circumvent the need for DNA extraction. The PCR process facilitates lysis of the bacterial cell wall, releasing nucleic acids, which can then be amplified by Taq polymerase. For the PCR procedure, two groups were formed, each comprising three replicates of the reaction with different DNA templates. The first group utilized a direct culture of Escherichia coli, while the second group incorporated the extracted DNA of Escherichia coli. Our study successfully amplified the metH gene of Escherichia coli without DNA extraction. Electrophoresis analysis revealed that the direct PCR product, sized at 300 bp, appeared more pronounced than the standard PCR product. The findings of this research demonstrated direct PCR as an alternative for detecting Escherichia coli, which would lead to reductions in costs, time, and labor.
Meningkatkan Preservasi DNA asal Saliva melalui Inaktivasi DNase I: Peran Suhu dan EDTA Yamamoto, Zulham; Sulviani, Nurul; Widjaja, Sry Suryani
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.152-162

Abstract

Background Deoxyribonuclease I (DNase I) catalyzes the cleavage of double-stranded DNA into its end products. This enzyme requires cations for its activity. In addition, DNase activity is influenced by indirect DNase inhibitors (i.e. EDTA) and temperature. EDTA is an indirect DNase I inhibitor. Therefore, DNase inactivation is crucial for DNA preservation, especially for salivary samples, and the downstream application of genetic techniques using non-blood samples. Saliva is a complex mixture contaminated with oral microbes and contains DNase which is harmful for DNA preservation. This study aims to preserve salivary DNA through temperature and EDTA treatment. Methods This is an experimental study. Salivary DNA was extracted using the spin-column method. DNA degradation assays were carried out using either 5 µL of salivary supernatant or 2.5 mg/mL of DNase I which were incubated at -20°C, 2-8°C, room temperature, 40°C, and 50°C; and added with 0.125 mM, 0.25 mM, 0.5 mM, 1 mM, and 2 mM EDTA for 60 minutes. After incubation, the results were visualized using agarose gel electrophoresis. Results The average concentration of salivary DNA was 61.70 µg/mL (30.50-109.05) and the purity was 1.893 µg/mL (1.800-2.005). Incubation at -20°C, 2-8°C, and room temperature degraded salivary DNA but incubation at 40 and 50°C did not completely degrade DNA. Addition 0.125 mM, 0.25 mM, 0.5 mM, 1 mM, and 2 mM EDTA to 5 µL of salivary supernatant or 2.5 mg/mL DNase I preserved salivary DNA. Conclusions Temperature of 40 and 50°C, and 0.125 mM EDTA can inactivate DNase and preserve salivary DNA.
Health Nutrition and Sanitation Counseling Education in Improving Health Understanding in Sigapiton Village, Ajibata District, North Sumatra. Rusdiana; Lubis, Nenni Dwi Aprianti; Savira, Maya; Widjaja, Sry Suryani
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 2 (2021): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (890.738 KB) | DOI: 10.32734/abdimastalenta.v6i2.4970

Abstract

Healthy environmental sanitation and good nutrition are factors that determine human resources and quality of life. With healthy environmental sanitation, the community is protected from various infectious diseases and similarly with a good understanding of nutrition will produce individuals with good quality. For this reason, it is important to achieve resources and good quality of life. This understanding is enhanced by providing health education. and good nutrition so that people are protected from various diseases. Health matters are matters of the environment, attitudes and behavior of the community. One of the causes of this nutritional deficiency is stunting, namely short stature in which a child who is stunted produces a low level of intelligence. For this reason, it is necessary to educate the public to understand the importance of good nutrition for children's growth. There is a wrong perception in the general public that stature is a hereditary factor, not a factor in malnutrition so that they do not pay attention to the nutritional status of children. Wrong choice of food for consumption, as well as nutritional balance between intake and output of substances (nutritional imbalance), namely intake that exceeds output or vice versa is the result of nutritional problems that occur in toddlers. This causes several impacts, including chronic disease, overweight and underweight, pica, dental caries, and allergies. For this reason, in this case the community service team wants to provide education about counseling to the community where the targets to be carried out are pregnant women, school children and young women. During the Covid 19 pandemic, the targets we educate are through cadres and village officials, this is to avoid infection with the covid 19 virus. By providing counseling to cadres and village officials, we hope that it will reach the people of Sigapiton village. Where in this counseling we provide pocket books to the cadres and village officials that we educate. We hope that this service can increase public knowledge about nutrition understanding and the creation of healthy environmental sanitation. We will publish the output of this service in an international journal indexed by Scopus
Comparison Ghrehlin at Obesity Without Metabolic Sydrome With Obesity with Metabolic Syndrome Rusdiana; Savira, Maya; Widjaja, Sry Suryani
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 1 (2021): ABDIMAS TALENTA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.499 KB) | DOI: 10.32734/abdimastalenta.v6i1.5864

Abstract

Obesity is principal causative factor in the development of metabolic syndrome and Ghrelin as human natural hormones is involved in fundamental regulatory processof eating and energy balance.Obesity, which has become a global public health problem, is one of the major risk factors for development metabolic syndrome and type 2 diabetes mellitus.This study aimed to analyze the comparison of ghrelin hormone levels in obese with metabolic syndrome and obese non metabolic syndrome . The sample population is obese adults, then we examined the weight, height, waist size, blood pressure, laboratory tests such as blood sugar levels and lipid profile of sample population to separate obese with metabolic syndrome and obese non metabolic syndrome. After we determined each group we measured stress oxidative levels in blood in obese with metabolic syndrome and obese non metabolic syndrome by ELISA method.With statistical analysis using T test found that there was significant difference of ghrelin hormone levels between obese with metabolic syndrome and obese without metabolic syndrome (p<0.005).
Increasing the Capacity of Paud Teachers with Training of Educators on School Health Business Activities in Early Children Education Park in Marelan City Rusdiana, Rusdiana; Widjaja, Sry Suryani; Amelia, Rina; Rusmalawaty, Rusmalawaty; AA, Rizka; Y, Devi; C, Teguh; W, Steven; EM, Samuel
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 2 (2023): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/abdimastalenta.v8i2.9280

Abstract

Improve healthy and clean-living behavior starting from early childhood, this can affect the growth and development of children and also the level of intelligence of children to produce a healthy and quality generation. The North Sumatra Kahmi Amanah Playgroup where early childhood education is located in the Medan Marelan area is a potential place that should be developed for early childhood education. School Health Business Activity is an activity that can foster clean and healthy behavior from an early age in children in the surrounding area who are children around Marelan area. The community service team funded by the University of North Sumatra through the LPPM institution consisting of lecturers from the Faculty of Medicine with different departments and also lecturers from the Faculty of Public Health is engaged in providing training to improve the skills of educators for school health business activities as well as providing medical equipment and facilities. needed and not yet available in the Amanah Kahmi playgroup, such as closed trash cans, making hand washing sinks, and thermogenic so that this community service activity can produce something useful for the community around the Medan Marelan area.
Gambaran Tingkat Pengetahuan dan Pemilihan Pengobatan Ketombe pada Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Sriwulan, Anyelin; Dalimunthe, Dina Arwina; Paramita, Deryne Anggia; Widjaja, Sry Suryani; Samosir, Fauzan Azmi Hasti Habibi
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 2 (2023): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i2.10495

Abstract

Latar Belakang. Ketombe merupakan gangguan kulit kepala yang ditandai dengan pengelupasan abnormal pada kulit kepala. Ada tiga penyebab utama yang menimbulkan ketombe yaitu jamur Malassezia, sekresi kelenjar sebasea, dan sensitivitas individu. Berbagai macam pengobatan telah banyak dilakukan untuk mengatasi masalah ketombe. Tujuan. Untuk mengetahui tingkat pengetahuan dan pemilihan pengobatan ketombe pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Angkatan. Metode. Penelitian ini bersifat deskriptif menggunakan metode pendekatan studi potong-lintang. Sampel penelitian merupakan mahasiswa Fakultas Kedokteran Universitas Sumatera Utara. Pengumpulan data menggunakan kuesioner yang disebarkan secara online melalui Google form dan QR Code. Hasil. Didapatkan mahasiswa memiliki pengetahuan yang baik tentang ketombe (92,1%). Berdasarkan pemilihan pengobatan ketombe, sumber informasi didapatkan melalui media elektronik (84,2%), tempat membeli obat di swalayan/mal (72,6%), cara memilih pengobatan ketombe hanya menggunakan sampo saja (63,7%), faktor pemilihan pengobatan ketombe karena mudah didapatkan (71,1%), alasan pemilihan pengobatan ketombe karena kandungan yang terdapat di dalam sampo sangat bagus (58,4%), bahan yang dipilih dalam pemilihan pengobatan ketombe menggunakan bahan alami dan bahan kimia (51,1%). Kesimpulan. Tingkat Pengetahuan mahasiswa baik tentang ketombe. Berdasarkan pemilihan pengobatan ketombe, sumber informasi yang paling banyak didapatkan responden melalui media elektronik, tempat responden membeli obat paling banyak di swalayan/mal, cara responden dalam memilih pengobatan ketombe paling banyak hanya menggunakan sampo, faktor pemilihan pengobatan ketombe responden paling banyak karena mudah didapatkan, alasan pemilihan pengobatan ketombe responden paling banyak karena kandungan yang terdapat dalam sampo sangat bagus, bahan yang dipilih responden dalam pemilihan pengobatan ketombe paling banyak menggunakan bahan alami dan bahan kimia.
Co-Authors AA, Rizka Aldy Safruddin Rambe Ameta Primasari C, Teguh Denny Rifsal Siregar Dina Arwina Dalimunthe, Dina Arwina EM, Samuel Ervina Sofyanti Farhat Harahap, Desy Aryani Hasibuan, Anggiriani Mutiara Sari Lubis, Inke Nadia D. Lubis, Nenni Dwi Aprianti M. PANDAPOTAN NASUTION Maya Savira Mayasari, Evita Melya Susanti Michael Dany Muhammad Ichwan Nova Eininta Sitepu Paramita, Deryne Anggia Raudah Putri Syari RICA VERA BR TARIGAN Rifqi Hamdani Pasaribu Rina Amelia Ririe F. Malisie Ririe Fachrina Malisie rusdiana Rusdiana Rusdiana Rusmalawaty, Rusmalawaty Samosir, Fauzan Azmi Hasti Habibi Simamora, Rizka Amini Sriwulan, Anyelin Sulviani, Nurul Thantrira Porntaveetus W, Steven Y, Devi Yamamoto, Zulham Yudhistira, Ashri