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All Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Tiara Ajeng L.
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Health Professions Nursing Public Health

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Aktivitas Penghambatan Enzim α-Amilase Ekstrak Etanol dan Fraksi Buah Belimbing Wuluh (Averrhoa bilimbi L.) Diana Nurrah Ashari; Tiara Ajeng L.; Danang Raharjo
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 6 (2024): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i6.813

Abstract

The enzyme α-amylase is one of the enzymes that plays a role in the process of degrading starch into maltose and glucose. Organic compounds such as polyphenols and flavonoids are inhibitors of α-amylase. The star fruit plant (Averrhoa bilimbi L.) has α-amylase enzyme inhibition activity and has the potential to be used in the therapy of type 2 diabetes mellitus. This study aims to determine whether ethanol extract and the fraction of star fruit (Averrhoa bilimbi L.) have α-amylase enzyme inhibition activity, inhibition against α-amylase enzyme and better inhibition activity. The test of α-amylase enzyme inhibition activity was carried out using 3 test groups, namely negative control, positive control (acarbose) and samples (ethanol extract and star fruit fraction) with concentrations of 12.5 ppm, 25 ppm, 50 ppm, 100 ppm and 200 ppm. The results of testing the inhibitory activity of α-amylase enzyme of ethanol extract and the fraction of star fruit (Averrhoa bilimbi L.) obtained IC50 values of 5.581 μg/mL, 76.725 μg/mL, 43.152 μg/mL and 55.447 μg/mL, respectively. Based on these results, it can be concluded that the ethanol extract of star fruit (Averrhoa bilimbi L.) at a concentration of 200 ppm has a very strong activity in inhibiting the α-amylase enzyme with an inhibition percentage of 85.217% and an IC50 value of 5.581 μg/mL.
Co-Authors Danang Raharjo Diana Nurrah Ashari