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Eva Vidella
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Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

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Studi Eksperimental Pengaruh Waktu Pemaparan Asap Obat Anti Nyamuk Bakar pada Perubahan Histopatologi Ginjal Tikus Jantan Wistar Eva Vidella; Mulyati Sri Rahayu; Khairunnisa Khairunnisa
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6707

Abstract

Mosquito coil smoke is the most commonly used insecticide by the public for mosquito control. The main active ingredient in these products is a pyrethroid derivative called Allethrin, which can generate free radicals that potentially damage the kidneys. This study aimed to evaluate the effect of varying durations of exposure to mosquito coil smoke on the histopathological features of the kidneys in male Wistar rats (Rattus norvegicus). The research employed a laboratory experimental method with a Post-Test Only Group Design. A total of 24 male Wistar rats were divided into four groups: a control group without treatment and three treatment groups exposed to mosquito coil smoke for 5 hours, 7 hours, and 9 hours per day over 21 days. After the treatment period, the rats were euthanized by cervical dislocation, their kidneys were harvested, and histopathological preparations were made and scored using the Venient et al. scoring system. Statistical analysis using the Kruskal-Wallis and Mann-Whitney tests revealed significant differences in kidney damage between the control and treatment groups (p < 0.001). The study concluded that varying durations of exposure to mosquito coil smoke cause significant differences in kidney histopathological damage in rats, with the most severe damage observed in the group exposed for 9 hours per day.
LAPORAN KASUS TUBERKULOSIS PARU: PENDEKATAN DIAGNOSTIK DAN EVALUASI TERAPI Eva Vidella
Integrative Perspectives of Social and Science Journal Vol. 3 No. 02 Februari (2026): Integrative Perspectives of Social and Science Journal
Publisher : PT Wahana Global Education

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Abstract

Tuberkulosis paru merupakan penyakit infeksi menular yang disebabkan oleh Mycobacterium tuberculosis dan masih menjadi masalah kesehatan utama di Indonesia. Laporan kasus ini membahas seorang laki-laki 55 tahun yang datang ke IGD RSUD Cut Meutia dengan keluhan batuk berdahak sejak kurang lebih tiga minggu yang memberat dalam dua hari terakhir, disertai nyeri dada saat batuk, demam naik turun, penurunan berat badan, nafsu makan menurun, keringat malam, serta mudah lelah. Pemeriksaan fisik menunjukkan keadaan umum sakit sedang dengan tanda vital relatif stabil, dan pada auskultasi paru ditemukan suara vesikuler melemah pada segmen apikal kedua paru disertai ronki bilateral. Pemeriksaan laboratorium menunjukkan anemia ringan dan trombositosis, sedangkan foto toraks menunjukkan deviasi trakea ke kanan, penebalan hilus, peningkatan corakan bronkovaskular, kavitas bilateral, bayangan berawan serta bercak milier pada kedua lapang paru dengan kesan tuberkulosis paru aktif. Pasien ditegakkan diagnosis tuberkulosis paru dan diberikan penatalaksanaan berupa edukasi, tirah baring, terapi nutrisi, terapi suportif, serta pemberian OAT kombinasi dosis tetap 4FDC disertai terapi adjuvan lainnya. Evaluasi klinis harian menunjukkan perbaikan bertahap dan pasien direncanakan menjalani pemeriksaan lanjutan untuk mendukung pemantauan terapi.
Co-Authors Khairunnisa Khairunnisa Mulyati Sri Rahayu