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All Journal Bali Dermatology Venereology and Aesthetic Journal
Luh Made Mas Rusyanti
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Focus on the dabrafenib, vemurafenib, and trametinib in the clinical outcome of melanoma: A systematic review and meta-analysis Ida Ayu Widya Anjani; Anak Agung Bagus Putra Indrakusuma; I Gede Krisna Arim Sadeva; Putri Ayu Wulandari; Luh Made Mas Rusyanti; Prima Sanjiwani Saraswati Sudarsa; I Gede Putu Supadmanaba; Desak Made Wihandani
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 2 (December 2020)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/myphje28

Abstract

Background: Melanoma is the most severe lethal skin cancer, affecting melanin producer cells (melanocytes). Surgery is the most common treatment, whereas, for the advanced stage, the development of treatment is recommended. BRAF (Dabrafenib and Vemurafenib) inhibitor or MEK inhibitor (Trametinib) is the most frequently targeted melanoma therapy due to more than 80% of patients with positive BRAF mutation. In this review, those treatments will be investigated systematically to identify their clinical outcome. Method: This systematic literature review (SLR) was performed from Cochrane, Science Direct, Google Scholar, and Pubmed. Cochrane Risk-of-Bias Tool RoB2 is used to assess RCT studies and New-castle Ottawa Scale Assessment to assess cohort studies by three different assessors. Data analysis was carried out by using Review Manager (RevMan 5.4). Heterogenicity test was assessed by I2 and Chi2 statistic Result: There are 20 studies used in this article (13 RCT and seven cohorts). The overall survival (OS) and progression-free survival (PFS) of the survey that using targeted therapy (vemurafenib, trametinib, or dabrafenib) compare other treatments (chemotherapy, immunotherapy, etc.) showed risk ratio (RR) was 1.12 (95%CI 1.07,1.17; I2=100%; p<0,00001). The OS and PFS with monotherapy compare of vemurafenib, trametinib, or dabrafenib with combination therapy showed RR was 1.09 (95%CI.06,1.13; I2=99%; p<0,00001). Conclusion: BRAF and MEK targeted therapy has a good prognosis for a patient with a positive BRAF gene mutation and could be combined with other treatments for better clinical outcomes rather than monotherapy.
COVID-19 and ophthalmic herpes zoster co-infection in immunocompetent patient Sissy; Adeline Santoso; Dewi Gotama; Luh Made Mas Rusyanti
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 1 (June 2021)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/279pg511

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Background: Varicella-zoster virus (VZV) is a virus of human neurotropic that remains within ganglionic neurons in a latent state after the primary infection throughout the entire neuroaxis. Case: A male patient, 32 years old Javanese, consulted from the pulmonary division with complaints of vesicular eruption in the facial area on September 27, 2020. The patient was diagnosed with ophthalmic herpes zoster and a mild COVID-19 infection since 2 days ago and was hospitalized. Management in patients was acyclovir, methylprednisolone, with analgesics and vitamins. COVID-19 as co-infection and other viruses has been known, but infrequently affect the respiratory tract. Conclusion: Herpes zoster patient should ruled out the COVID-19 and maximize the precaution for personal safety equipment until the SARS-CoV-2 is excluded.
Beneficial effects of simvastatin in wound healing: review of the literature Chandra Wijaya Setiawan; Luh Made Mas Rusyanti; Marrietta Sugiarti Sadeli
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 1 (June 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ajes2h80

Abstract

Wound healing is a complex, natural biological, and dynamic process or loss of cellular structures, tissue layers, and replacing damaged tissue. Molecular responses, cellular components, and humoral components are healing process that occurs in hemostasis, including inflammation, proliferation, and remodeling. In order to achieve good healing, these four steps must be performed in the right order and at the right time. In recent years, research has shown that simvastatin has pleiotropic properties that have been linked to improved wound healing in experimental animals and humans. However, higher-quality and evidence-based research is needed to determine the duration of treatment, the best method of administration, the correct dose, and to relate the pleiotropic properties of simvastatin to its potential therapeutic.
High levels of zinc (Zn) as a protective factor and negatively correlated with IgM anti PGL-1 levels among household contact with multibacillary leprosy patients Adeline Santoso; Luh Made Mas Rusyanti; Ketut Kwartantaya Winaya
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 1 (June 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/mpyc7w03

Abstract

Background: Close contacts may develop subclinical leprosy with no symptoms but with M. leprae in their blood. Zinc is said to help in the prevention of M. leprosy infection. This study aimed to determine the correlation between zinc (Zn) serum levels and IgM anti PGL-1 levels in household contacts of multibacillary type leprosy patients. Methods: This study is cross-sectional and involves 48 leprosy subjects (33 multibacillary leprosy household contact and 15 non-contact subjects). Subjects were selected based on the inclusion and exclusion criteria. Zinc and IgM anti PGL-1 levels were derived from venous blood examined with ELISA. Results: This study showed the mean serum zinc level of the contact groups of 60.88 ± 15.92 μg/dl and the non-contact group of 90.00 ± 7.61 μg / dl (p <0.001; CI 95%: 20.38 - 37.85). The median (interquartile range) serum levels of IgM anti PGL-1 in the contact groups was 613.00 (40 - 1433) u/ml and the non-contact groups was 99.00 (14 - 695) u/ml (p = 0.001; 95% CI: 154.162 – 610.116). The correlation analysis between serum zinc levels and IgM anti PGL-1 serum levels r= 0.644 (p<0.05). A high serum zinc level is a protective factor against high IgM anti PGL-1 levels in household contact with leprosy (PR: 0.47; 95% CI: 0.20-1.09). Conclusion: Zinc levels negatively correlate with IgM anti PGL-1 levels in subjects with household contact with multibacillary type leprosy. A high serum zinc level protects against high IgM anti PGL-1 levels.
Co-Authors Adeline Santoso Anak Agung Bagus Putra Indrakusuma Chandra Wijaya Setiawan Desak Made Wihandani Dewi Gotama I G. P. Supadmanaba I Gede Krisna Arim Sadeva Ida Ayu Widya Anjani Ketut Kwartantaya Winaya Marrietta Sugiarti Sadeli Prima Saraswati Sanjiwani Sudarsa Putri Ayu Wulandari Sissy