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All Journal International Journal of Contemporary Sciences (IJCS)
Putri, Diah Karika
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Religion Humanities Decision Sciences, Operations Research & Management Education

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Synergistic Antihyperglycemic Effects of Soursop Leaves and Garlic in Alloxan-Induced Rats Suswidiantoro, Vicko; Safutri, Wina; Pratiwi, Mida; Putri, Diah Karika; Dwiningrum, Riza; Lestari, Fina Aulika
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 12 (2024): October 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i12.12038

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production. Natural remedies, such as soursop leaves (Annona muricata) (SL) and garlic (Allium sativum) (GAR), are known for their antihyperglycemic properties. This study aimed to investigate the effects of SL and GAR extracts, individually and in combination, on reducing blood glucose levels in alloxan-induced diabetic rats. A total of 24 male Wistar rats were divided into six groups, receiving treatments of either metformin, SL, GAR, or their combination for seven days following alloxan administration to induce hyperglycemia. Blood glucose levels were measured before and after induction, and post-treatment on day 15. The results showed that the combined extracts exhibited better antihyperglycemic activity compared to individual treatments, with the most effective dose being 26.3 mg/kg BW SL + 31.5 mg/kg BW GAR.
Co-Authors Lestari, Fina Aulika Mida Pratiwi Riza Dwiningrum, Riza Suswidiantoro, Vicko Wina Safutri