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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Galenika
Sabrina, Maiyeni
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Medicine & Pharmacology Public Health

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PERAN INDEKS MASSA TUBUH TERHADAP KADAR TESTOSTERON PADA PRIA DIABETES MELITUS TIPE 2 DENGAN TERAPI METFORMIN Sabrina, Maiyeni; Lukas, Stefanus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2721

Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder often accompanied by decreased testosterone levels in men. Metformin is effective in lowering blood glucose, but its impact on testosterone remains controversial.To evaluate the effects of metformin dose, age, and changes in body mass index (BMI) on testosterone levels in men with T2DM. A pre–post study was conducted on 79 male T2DM patients receiving metformin. Data included metformin dose, age, BMI, and testosterone levels before and after therapy. Spearman correlation and multiple linear regression were used for analysis. Changes in BMI showed a strong correlation (ρ = 0.608; p = 0.000) and metformin dose showed a moderate correlation (ρ = 0.564; p = 0.000) with changes in testosterone. Regression analysis identified BMI as the dominant factor (β = 0.523; p = 0.009), while age was not significant (p > 0.05). This study provides simultaneous analysis of metformin dose, BMI, and age using a pre–post design. A unique finding was that BMI reduction was followed by decreased testosterone levels, contrasting with most international studies. Changes in BMI were the most dominant factor influencing testosterone levels in men with T2DM receiving metformin.
Evaluasi Efektivitas Metode Uji Dan Terapeutik Outcome Pada Pasien Malaria Di Kabupaten Kepulauan Tanimbar Sorluri, Florentina; Prima, Sylvia Rizky; Sabrina, Maiyeni
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.439

Abstract

Malaria remains a significant public health problem in tropical countries, including Indonesia. According to the World Health Organization (WHO) report in 2021, there were approximately 229 million malaria cases and 409,000 deaths worldwide in 2019. In Indonesia, malaria remains endemic in several regions, including the Tanimbar Islands Regency, where tropical environmental conditions support the breeding of Anopheles mosquitoes as the primary vector. This study aimed to evaluate diagnostic methods and therapeutic outcomes among malaria patients in this region. The study employed a cross-sectional design with a total sample size of 200 respondents (n = 200). Statistical analysis was conducted using the McNemar test and chi-square test.The results showed that the majority of respondents were female, aged 15–49 years (71%). Based on occupation, malaria cases were most commonly found among individuals in informal sectors such as fishermen, farmers, and laborers (33.5%), with most respondents having a senior high school level of education (54.5%). The predominant infection was caused by Plasmodium vivax, with most patients exhibiting moderate levels of parasitemia. Most patients achieved recovery after receiving treatment. Statistical analysis indicated a significant difference between Rapid Diagnostic Test (RDT) and microscopic examination methods in malaria diagnosis. Furthermore, there was a significant association between the diagnostic methods used and patients’ therapeutic outcomes (p < 0.05), as well as between parasitemia levels and RDT results in determining the effectiveness of malaria diagnosis.
Co-Authors Lukas, Stefanus Prima, Sylvia Rizky Sorluri, Florentina